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- Hillier, Ladeana W, et al.
(författare)
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Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution
- 2004
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Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 432:7018, s. 695-716
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Tidskriftsartikel (refereegranskat)abstract
- We present here a draft genome sequence of the red jungle fowl, Gallus gallus. Because the chicken is a modern descendant of the dinosaurs and the first non-mammalian amniote to have its genome sequenced, the draft sequence of its genome--composed of approximately one billion base pairs of sequence and an estimated 20,000-23,000 genes--provides a new perspective on vertebrate genome evolution, while also improving the annotation of mammalian genomes. For example, the evolutionary distance between chicken and human provides high specificity in detecting functional elements, both non-coding and coding. Notably, many conserved non-coding sequences are far from genes and cannot be assigned to defined functional classes. In coding regions the evolutionary dynamics of protein domains and orthologous groups illustrate processes that distinguish the lineages leading to birds and mammals. The distinctive properties of avian microchromosomes, together with the inferred patterns of conserved synteny, provide additional insights into vertebrate chromosome architecture.
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| 4. |
- Agostoni, Angelo, et al.
(författare)
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Hereditary and acquired angioedema: problems and progress: proceedings of the third C1 esterase inhibitor deficiency workshop and beyond
- 2004
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Ingår i: Journal of Allergy and Clinical Immunology. - : Elsevier BV. - 1097-6825 .- 0091-6749. ; 114:3 Suppl, s. 51-131
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Tidskriftsartikel (refereegranskat)abstract
- Hereditary angioedema (HAE), a rare but life-threatening condition, manifests as acute attacks of facial, laryngeal, genital, or peripheral swelling or abdominal pain secondary to intra-abdominal edema. Resulting from mutations affecting C1 esterase inhibitor (C1-INH), inhibitor of the first complement system component, attacks are not histamine-mediated and do not respond to antihistamines or corticosteroids. Low awareness and resemblance to other disorders often delay diagnosis; despite availability of C1-INH replacement in some countries, no approved, safe acute attack therapy exists in the United States. The biennial C1 Esterase Inhibitor Deficiency Workshops resulted from a European initiative for better knowledge and treatment of HAE and related diseases. This supplement contains work presented at the third workshop and expanded content toward a definitive picture of angioedema in the absence of allergy. Most notably, it includes cumulative genetic investigations; multinational laboratory diagnosis recommendations; current pathogenesis hypotheses; suggested prophylaxis and acute attack treatment, including home treatment; future treatment options; and analysis of patient subpopulations, including pediatric patients and patients whose angioedema worsened during pregnancy or hormone administration. Causes and management of acquired angioedema and a new type of angioedema with normal C1-INH are also discussed. Collaborative patient and physician efforts, crucial in rare diseases, are emphasized. This supplement seeks to raise awareness and aid diagnosis of HAE, optimize treatment for all patients, and provide a platform for further research in this rare, partially understood disorder.
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| 6. |
- Bigler, Christian, 1972-
(författare)
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Diatoms as indicators of Holocene climate and environmental change in northern Sweden
- 2001
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The objective of the thesis was to explore the potential of diatoms (Bacillariophyceae) as indicators of Holocene climate and environmental change in northern Sweden (Abisko region, 68°21'N, 18°49'E). A modern surface-sediment calibration set including 100 lakes was developed and lake-water pH, sedimentary organic content (assessed by loss-on-ignition) and temperature were identified as most powerful environmental variables explaining the variance within the diatom assemblages. Transfer functions based on unimodal species response models (WA-PLS) were developed for lake-water pH and mean July air temperature (July T), yielding coefficients of determination of 0.77 and 0.70, and prediction errors based on leave-one-out cross-validation of 0.19 pH units and 0.96 °C for lake-water pH and July T, respectively. The transfer functions were validated with monitoring data covering two open-water seasons (lake-water pH) and meteorological records covering the 20th century (July T). The good agreement between diatom-based inferences and measured monitoring data confirmed the prediction ability of the developed transfer functions. Analysing a Holocene sediment core from a lake nearby Abisko (Vuoskkujávri), diatoms infer a linearly decreasing July T trend (1.5 °C) since 6,000 cal. BP, which compares well with inferences based on chironomids and pollen from the same sediment core. The lake-water pH inference shows a pattern of moderate natural acidification (c. 0.5 pH units) since the early Holocene, reaching present-day pH values at c. 5,000 cal. BP. By fitting fossil diatom samples to the modern calibration set by means of residual distance assessment within canonical correspondence analysis (CCA), the early Holocene (between 10,600 and 6,000 cal. BP) was identified as a problematic time-period for diatom-based inferences and, consequently, reconstructions during this period are tentative. Pollen-based inferences also show 'poor' fit between 10,600 and 7,500 cal. BP and chironomids probably provide the most reliable July T reconstruction at Vuoskkujávri, with 'poor' fit only during the initial part of the Holocene (between 10,600 and 10,250 cal. BP). Possible factors confounding diatom-based July T inferences were investigated. Using detrended CCA (DCCA), Holocene sediment sequences from five lakes indicate that during the early Holocene, mainly physical factors such as high minerogenic erosion rates, high temperature and low light availability may have regulated diatom assemblages, favouring Fragilaria species. In all five lakes, diatom assemblages developed in a directional manner, but timing and scale of development differed substantially between lakes. The differences are attributed primarily to the geological properties of the lake catchments (with strong effects on lake-water pH), but other factors such as climatic change, vegetation, hydrologic setting and in-lake processes appear to regulate diatom communities in each lake differently. The influence of long-term natural acidification on diatom assemblages progressively declined during the Holocene with corresponding increase of the influence of climatic factors.
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- Escobar Kvitting, John-Peder, 1976-, et al.
(författare)
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Flow patterns in the aortic root and the aorta studied with time-resolved, 3-dimensional, phase-contrast magnetic resonance imaging : implications for aortic valve–sparing surgery
- 2004
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Ingår i: Journal of Thoracic and Cardiovascular Surgery. - : Elsevier BV. - 0022-5223 .- 1097-685X. ; 127:6, s. 1602-1607
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Tidskriftsartikel (refereegranskat)abstract
- ObjectiveSparing the aortic valve has become a surgical option for patients who require repair of aortic root ectasia and have normal valve leaflets. Surgical approaches to valve sparing differ with regard to preservation of the native sinuses of Valsalva. The role of the sinuses and the importance of maintaining them remain controversial.MethodsBy using a time-resolved, 3-dimensional, phase-contrast magnetic resonance imaging technique, aortic root and aortic blood velocity data were acquired from 2 patients with Marfan syndrome 6 months after aortic valve–sparing surgery with straight Dacron grafts and contrasted with data from 6 normal volunteers.ResultsIn normal aortas vortical blood flow became apparent in the individual sinuses after peak systole. The vortices filled the available space behind the valve leaflets and persisted until diastole, expanding and moving inward during aortic valve closure. In contrast, no vortices were observed in the postoperative patients with Marfan syndrome with negligible sinuses.ConclusionsChanges in supravalvular flow accompany loss of sinus architecture. Whether the presence, size, and velocity of supravalvular vortices affects the function or durability of the preserved aortic valve remains to be studied.
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| 8. |
- Gubanov, Alexander P., et al.
(författare)
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Anabarella australis (Mollusca, Helcionelloida) from the Lower Cambrian of Greenland
- 2004
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Ingår i: Geobios. - : Elsevier BV. - 0016-6995 .- 1777-5728. ; 37:6, s. 719-724
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Tidskriftsartikel (refereegranskat)abstract
- The Early Cambrian helcionelloid mollusc Anabarella australis is described from North-East Greenland, representing the second occurrence of the species outside of Australia. Other Australian molluscs of this age are known from many localities including North China, Siberia, Altai, Transbaikalia, southern Kazakhstan, Mongolia, eastern Germany and Spain. These records, supported now by A. australis, demonstrate the close proximity of continents in the Early Cambrian.
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| 9. |
- Kamp-Nielsen, Christian, et al.
(författare)
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The leukotriene receptor CysLT1 and 5-lipoxygenase are upregulated in colon cancer.
- 2003
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Ingår i: Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research. - Boston, MA : Springer US. - 0065-2598. - 9780306477638 ; 525, s. 201-204
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Bokkapitel (refereegranskat)abstract
- The metabolites of arachidonic acid are well connected to pathological situations such as inflammation, cancer and asthmA. Sheng et al. [7] found that COX-2 is upregulated in colon cancer tissue and tumor cell lines indicating that COX-2 is involved in colon cancer. This is supported by studies showing that patients treated with nonsteroidal anti-inflammatory drugs, inhibitors of COX-2, exhibit a lower frequency of colon cancer [8]. When the non-transformed intestinal epithelial cell line, Int 407 was stimulated with LTD4 or LTB4 we observed an accumulation of COX-2 in membrane fractions as well as an increased production of prostaglandin E2 [5]. Treatment of these cells with the COX-2 inhibitor NS-398 caused apoptosis and this effect could be prevented by LTD4 [5] or LTB4 [4]. Similar results were obtained when cell viability with LTD4 or LTB4 in the presence or absence of NS-398 was assayed [4,5]. The results demonstrate that these leukotrienes can suppress the NS-398 induced apoptosis in intestinal cells.
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