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- Svensson, Johan, 1964, et al.
(författare)
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Treatment with the oral growth hormone secretagogue MK-677 increases markers of bone formation and bone resorption in obese young males.
- 1998
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Ingår i: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. - 0884-0431. ; 13:7, s. 1158-66
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Tidskriftsartikel (refereegranskat)abstract
- The effect of 2 months of treatment with the oral growth hormone (GH) secretagogue MK-677 on markers of bone metabolism was determined in healthy obese male subjects. This was a randomized, double-blind, parallel, placebo-controlled study. Twenty-four healthy obese males, 19-49 years of age, with body mass index > 30 kg/m2 were treated with MK-677 (25 mg/day; n = 12) or placebo (n = 12) for 8 weeks. MK-677 increased markers of bone formation; a 23% increase in the carboxy-terminal propeptide of type I procollagen levels and a 28% increase in procollagen III peptide levels were seen with as little as 2 weeks of MK-677 treatment (p < 0.01 and p = 0.001 vs. placebo, respectively) while a 15% increase in serum levels of osteocalcin was not detected until 8 weeks of treatment (p < 0.01 vs. placebo). Markers of bone resorption were induced within 2 weeks of treatment with MK-677; serum levels of the carboxy-terminal cross-linked telopeptide of type I collagen were increased 26% at 8 weeks (p = 0.001 vs. placebo), and urine hydroxyproline/creatinine and calcium/creatinine ratios at 8 weeks were increased by 23% (p < 0.05 vs. placebo) and 46% (p < 0.05 vs placebo), respectively, MK-677 increased serum insulin-like growth factor binding protein-5 (IGFBP-5) by 43-44% after 2-8 weeks of treatment (p < 0.01 vs. placebo). Serum IGFBP-4 was increased by 25% after 2 weeks of treatment (p < 0.001 vs. placebo) but no significant change from baseline was observed after 8 weeks of treatment. Plasma interleukin-6 was not significantly changed by active treatment. In conclusion, short-term treatment of healthy obese male volunteers with the GH secretagogue MK-677 increases markers of both bone resorption and formation. Large increases in serum levels of IGF-1 and IGFBP-5 and a transient increase in serum IGFBP-4 were found. Future long-term studies are needed to investigate if prolonged treatment with MK-677 increases bone mass.
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| 3. |
- Jemt, Torsten, 1950, et al.
(författare)
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A 5-year prospective multicenter follow-up report on overdentures supported by osseointegrated implants.
- 1996
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Ingår i: The International journal of oral & maxillofacial implants. - 0882-2786. ; 11:3, s. 291-8
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Tidskriftsartikel (refereegranskat)abstract
- This report presents the results of a 5-year prospective multicenter study including nine centers worldwide. A total of 30 patients received 117 Brånemark implants in the maxillae, and 103 patients received 393 implants in the mandibles. According to the protocol, all integrated maxillary implants were to be loaded; however, only two of four mandibular implants were planned for support of the overdentures, leaving the remaining implants covered by mucosa as backup for possible implant failures. Thirty-five patients (26.3%) who were provided with 127 implants (24.9%) were withdrawn from the study. Six patients treated in the maxilla lost all their implants and resumed wearing complete dentures. The cumulative success rates for implants and for overdentures supported by two implants in the edentulous mandible were 94.5% and 100%, respectively. The corresponding cumulative success rates for implants and for overdentures supported by an optimal number of implants in the maxilla were 72.4% and 77.9%, respectively. Significantly better jawbone characteristics at the time of implant surgery were considered to contribute to the better cumulative success rates in the mandibles. Mean marginal bone loss was 0.8 mm (SD 0.8) and 0.5 mm (SD 0.8) for loaded implants during a 5-year period of time in the maxillae and mandibles, respectively. Measurements of the clinical height of the abutment cylinders indicated a mean recession (0.2 mm) of peri-implant mucosa during the follow-up period in the mandibles. Conversely, hyperplasia was observed in the maxillae.
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| 8. |
- Piamonte, D. Paul T., et al.
(författare)
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Testing videophone graphical symbols in Southeast Asia
- 1999
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Ingår i: Human-computer interaction. - : IEEE Communications Society. ; , s. 793-797
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Konferensbidrag (refereegranskat)abstract
- This paper aimed to study how symbols designed and tested in Europe fared among subjects from different countries in Southeast Asia. It was part of an international study on graphic symbols involving countries from Southeast Asia. Specifically, videotelephone symbols designed and tested by the European Telecommunication Standards Institute (ETSI) were evaluated using subjects from five Southeast Asian countries.
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| 9. |
- Piamonte, D. Paul T., et al.
(författare)
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Understanding small graphical symbols : a cross-cultural study
- 1999
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Ingår i: Proceedings of the 10th year anniversary of M. Sc. ergonomics. - Luleå : Luleå University of Technology. Department of Human Work Sciences. Division of Industrial Ergonomics. ; , s. 274-280
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Konferensbidrag (refereegranskat)
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| 10. |
- Sims, D. A., et al.
(författare)
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The He(γ,n) reaction: a potential testing ground for the alpha-particle wavefunction
- 1998
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Ingår i: Physics Letters B. - 0370-2693. ; 442:1-4, s. 43-47
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Tidskriftsartikel (refereegranskat)abstract
- Differential cross sections (σ(Eγ,θn)) for the He(γ,n) reaction have been measured at Eγ=50–71 MeV and θn=30–120°. These data are compared with theoretical predictions where a microscopic calculation of the He and He wavefunctions has been made within the Alt-Grassberger-Sandhas, integral-equation formalism.
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