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- Guy-Haim, Tamar, et al.
(författare)
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What are the type, direction, and strength of species, community, and ecosystem responses to warming in aquatic mesocosm studies and their dependency on experimental characteristics? : A systematic review protocol
- 2017
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Ingår i: Environmental Evidence. - : Springer Science and Business Media LLC. - 2047-2382. ; 6:1
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Forskningsöversikt (refereegranskat)abstract
- Mesocosm experiments have become increasingly popular in climate change research as they bridge the gap between small-scale, less realistic, microcosm experiments, and large-scale, more complex, natural systems. Characteristics of aquatic mesocosm designs (e.g., mesocosm volume, study duration, and replication) vary widely, potentially affecting the magnitude and direction of effect sizes measured in experiments. In this global systematic review we aim to identify the type, direction and strength of climate warming effects on aquatic species, communities and ecosystems in mesocosm experiments. Furthermore, we will investigate the context-dependency of the observed effects on several a priori determined effect moderators (ecological and methodological). Our conclusions will provide recommendations for aquatic scientists designing mesocosm experiments, as well as guidelines for interpretation of experimental results by scientists, policy-makers and the general public. Methods: We will conduct a systematic search using multiple online databases to gather evidence from the scientific literature on the effects of warming experimentally tested in aquatic mesocosms. Data from relevant studies will be extracted and used in a random effects meta-analysis to estimate the overall effect sizes of warming experiments on species performance, biodiversity and ecosystem functions. Experimental characteristics (e.g., mesocosm size and shape, replication-level, experimental duration and design, biogeographic region, community type, crossed manipulation) will be further analysed using subgroup analyses.
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| 2. |
- Jones, Lesley, et al.
(författare)
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Convergent genetic and expression data implicate immunity in Alzheimer's disease
- 2015
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Ingår i: Alzheimer's & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 11:6, s. 658-671
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Tidskriftsartikel (refereegranskat)abstract
- Background: Late-onset Alzheimer's disease (AD) is heritable with 20 genes showing genome-wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underlying the disease, we extended these genetic data in a pathway analysis. Methods: The ALIGATOR and GSEA algorithms were used in the IGAP data to identify associated functional pathways and correlated gene expression networks in human brain. Results: ALIGATOR identified an excess of curated biological pathways showing enrichment of association. Enriched areas of biology included the immune response (P = 3.27 X 10(-12) after multiple testing correction for pathways), regulation of endocytosis (P = 1.31 X 10(-11)), cholesterol transport (P = 2.96 X 10(-9)), and proteasome-ubiquitin activity (P = 1.34 X 10(-6)). Correlated gene expression analysis identified four significant network modules, all related to the immune response (corrected P = .002-.05). Conclusions: The immime response, regulation of endocytosis, cholesterol transport, and protein ubiquitination represent prime targets for AD therapeutics.
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| 3. |
- Tayleur, Catherine, et al.
(författare)
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Swedish birds are tracking temperature but not rainfall: evidence from a decade of abundance changes
- 2015
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Ingår i: Global Ecology and Biogeography. - : Wiley. - 1466-8238 .- 1466-822X. ; 24:7, s. 859-872
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Tidskriftsartikel (refereegranskat)abstract
- Aim: To quantify avian distribution shifts and the extent of niche tracking in response to changing temperature and precipitation patterns. Location: Sweden. Methods: We used abundance monitoring data to quantify changes in bird species distributions between two time periods, 2000-02 and 2010-12. First we examined shifts at the level of whole distributions using population centroids in temperature, rainfall, altitude, latitude and longitude. We then characterized shifts in temperature and latitude at different parts of species ranges using species response curves (SRC). We accounted for yearly turnover in abundance and sampling effort, and compared the observed shifts with those expected under perfect niche tracking. Results: Most species demonstrated changes in their distributions over the last decade but not all were in response to weather. The degree to which species tracked their climatic niches and the dynamics driving these shifts varied considerably. Only 20% of species shifted in the direction expected given the temperature changes, while few showed a strong response to rainfall. Most shifts did not fully compensate for changes in temperature. Range changes were most evident at the leading edges, but there was some evidence for retractions of trailing edges. Amongst species that tracked temperature, those with southerly distributions were less successful at tracking changes than those in the north. Main conclusions: Swedish birds demonstrated highly dynamic distributions, with many rapid directional shifts occurring over the last decade. However, only a few species kept pace with observed climatic change. Species that did not track their climatic niche may be tolerant to ongoing climatic change or constrained by strong habitat requirements. We demonstrate that measuring range shifts along both environmental and geographic gradients can help disentangle drivers of distribution changes.
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| 5. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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