| 1. |
- Baresel, Christian, et al.
(författare)
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Functionalized magnetic particles for water treatment
- 2019
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Ingår i: Heliyon. - : Elsevier BV. - 2405-8440. ; 5:8
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Tidskriftsartikel (refereegranskat)abstract
- In this study, we have taken the concept of water treatment by functionalized magnetic particles one step forward by integrating the technology into a complete proof of concept, which included the preparation of surface modified beads, their use as highly selective absorbents for heavy metals ions (Zinc, Nickel), and their performance in terms of magnetic separation. The separation characteristics were studied both through experiments and by simulations. The data gathered from these experimental works enabled the elaboration of various scenarios for Life Cycle Analysis (LCA). The LCA showed that the environmental impact of the system is highly dependent on the recovery rate of the magnetic particles. The absolute impact on climate change varied significantly among the scenarios studied and the recovery rates. The results support the hypothesis that chelation specificity, magnetic separation and bead recovery should be optimized to specific targets and applications.
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| 2. |
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| 3. |
- Ahrentorp, Fredrik, et al.
(författare)
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Effective particle magnetic moment of multi-core particles
- 2015
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Ingår i: Journal of Magnetism and Magnetic Materials. - : Elsevier BV. - 0304-8853 .- 1873-4766. ; 380, s. 221-226
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Tidskriftsartikel (refereegranskat)abstract
- In this study we investigate the magnetic behavior of magnetic multi-core particles and the differences in the magnetic properties of multi-core and single-core nanoparticles and correlate the results with the nanostructure of the different particles as determined from transmission electron microscopy (TEM). We also investigate how the effective particle magnetic moment is coupled to the individual moments of the single-domain nanocrystals by using different measurement techniques: DC magnetometry, AC susceptometry, dynamic light scattering and TEM. We have studied two magnetic multi-core particle systems BNF Starch from Micromod with a median particle diameter of 100 am and FeraSpin R from nanoPET with a median particle diameter of 70 nm - and one single-core particle system - SHP25 from Ocean NanoTech with a median particle core diameter of 25 nm. (C) 2014 Elsevier B.V. All rights reserved.
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| 4. |
- Ahrentorp, Fredrik, et al.
(författare)
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Sensitive magnetic biodetection using magnetic multi-core nanoparticles and RCA coils
- 2017
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Ingår i: Journal of Magnetism and Magnetic Materials. - : Elsevier BV. - 0304-8853 .- 1873-4766. ; 427, s. 14-18
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Tidskriftsartikel (refereegranskat)abstract
- We use functionalized iron oxide magnetic multi-core particles of 100 nm in size (hydrodynamic particle diameter) and AC susceptometry (ACS) methods to measure the binding reactions between the magnetic nanoparticles (MNPs) and bio-analyte products produced from DNA segments using the rolling circle amplification (RCA) method. We use sensitive induction detection techniques in order to measure the ACS response. The DNA is amplified via RCA to generate RCA coils with a specific size that is dependent on the amplification time. After about 75 min of amplification we obtain an average RCA coil diameter of about 1 mu m. We determine a theoretical limit of detection (LOD) in the range of 11 attomole (corresponding to an analyte concentration of 55 fM for a sample volume of 200 mu L) from the ACS dynamic response after the MNPs have bound to the RCA coils and the measured ACS readout noise. We also discuss further possible improvements of the LOD.
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| 5. |
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| 6. |
- Blomgren, Jakob, et al.
(författare)
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Development of a sensitive induction-based magnetic nanoparticle biodetection method
- 2018
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Ingår i: Nanomaterials. - : MDPI AG. - 2079-4991. ; 8:11
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Tidskriftsartikel (refereegranskat)abstract
- We developed a novel biodetection method for influenza virus based on AC magnetic susceptibility measurement techniques (the DynoMag induction technique) together with functionalized multi-core magnetic nanoparticles. The sample consisting of an incubated mixture of magnetic nanoparticles and rolling circle amplified DNA coils is injected into a tube by a peristaltic pump. The sample is moved as a plug to the two well-balanced detection coils and the dynamic magnetic moment in each position is read over a range of excitation frequencies. The time for making a complete frequency sweep over the relaxation peak is about 5 minutes (10 Hz–10 kHz with 20 data points). The obtained standard deviation of the magnetic signal at the relaxation frequency (around 100 Hz) is equal to about 10−5 (volume susceptibility SI units), which is in the same range obtained with the DynoMag system. The limit of detection with this method is found to be in the range of 1 pM.
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| 7. |
- Chakkarapani, Prabu, et al.
(författare)
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Encapsulation of methotrexate loaded magnetic microcapsules for magnetic drug targeting and controlled drug release
- 2015
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Ingår i: Journal of Magnetism and Magnetic Materials. - : Elsevier BV. - 0304-8853 .- 1873-4766. ; 380, s. 285-294
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Tidskriftsartikel (refereegranskat)abstract
- We report on the development and evaluation of methotrexate magnetic microcapsules (MMC) for targeted rheumatoid arthritis therapy. Methotrexate was loaded into CaCO3-PSS (poly (sodium 4-styrenesulfonate)) doped microparticles that were coated successively with poly (allylamine hydrochloride) and poly (sodium 4-styrenesulfonate) by layer-by-layer technique. Ferrofluid was incorporated between the polyelectrolyte layers. CaCO3-PSS core was etched by incubation with EDTA yielding spherical MMC. The MMC were evaluated for various physicochemical, pharmaceutical parameters and magnetic properties. Surface morphology, crystallinity, particle size, zeta potential, encapsulation efficiency, loading capacity, drug release pattern, release kinetics and AC susceptibility studies revealed spherical particles of ~3 µm size were obtained with a net zeta potential of +24.5 mV, 56% encapsulation and 18.6% drug loading capacity, 96% of cumulative drug release obeyed Hixson-Crowell model release kinetics. Drug excipient interaction, surface area, thermal and storage stability studies for the prepared MMC was also evaluated. The developed MMC offer a promising mode of targeted and sustained release drug delivery for rheumatoid arthritis therapy.
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| 8. |
- Fock, Jeppe, et al.
(författare)
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Characterization of fine particles using optomagnetic measurements
- 2017
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Ingår i: Physical Chemistry, Chemical Physics - PCCP. - : Royal Society of Chemistry (RSC). - 1463-9076 .- 1463-9084. ; 19:13, s. 8802-8814
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Tidskriftsartikel (refereegranskat)abstract
- The remanent magnetic moment and the hydrodynamic size are important parameters for the synthesis and applications of magnetic nanoparticles (MNPs). We present the theoretical basis for the determination of the remanent magnetic moment and the hydrodynamic size of MNPs with a narrow size distribution using optomagnetic measurements. In these, the 2nd harmonic variation of the intensity of light transmitted through an MNP suspension is measured as a function of an applied axial oscillating magnetic field. We first show how the measurements of the optomagnetic signal magnitude at a low frequency vs. magnetic field amplitude can be used to determine the MNP moment. Subsequently, we use linear response theory to describe the dynamic non-equilibrium response of the MNP suspension at low magnetic field amplitudes and derive a link between optomagnetic measurements and magnetic AC susceptibility measurements. We demonstrate the presented methodology on two samples of commercially available multi-core MNPs. The results compare well with those obtained by dynamic light scattering, AC susceptibility and vibrating sample magnetometry measurements on the same samples when the different weighting of the particle size in the techniques is taken into account. The optomagnetic technique is simple, fast and does not require prior knowledge of the concentration of MNPs and it thus has the potential to be used as a routine tool for quality control of MNPs.
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| 9. |
- Jonasson, Christian, et al.
(författare)
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Modelling the effect of different core sizes and magnetic interactions inside magnetic nanoparticles on hyperthermia performance
- 2019
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Ingår i: Journal of Magnetism and Magnetic Materials. - : Elsevier BV. - 0304-8853 .- 1873-4766. ; 477, s. 198-202
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Tidskriftsartikel (refereegranskat)abstract
- We present experimental intrinsic loss power (ILP) values, measured at an excitation frequency of 1 MHz and at relatively low field amplitudes of 3.4–9.9 kA/m, as a function of the mean core diameter, for selected magnetic nanoparticles (MNPs). The mean core sizes ranged from ca. 8 nm to 31 nm. Transmission electron microscopy indicated that those with smaller core sizes (less than ca. 22 nm) were single-core MNPs, while those with larger core sizes (ca. 29 nm to 31 nm) were multi-core MNPs. The ILP data showed a peak at core sizes of ca. 20 nm. We show here that this behaviour correlates well with the predicted ILP values obtained using either a non-interacting Debye model, or via dynamic Monte-Carlo simulations, the latter including core-core magnetic interactions for the multi-core particles. This alignment of the models is a consequence of the low field amplitudes used. We also present interesting results showing that the core-core interactions affect the ILP value differently depending on the mean core size.
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| 10. |
- Jonasson, Christian, et al.
(författare)
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Utvärdering av onlinesystem för tidig varning av fekal påverkan i råvatten. Baserad på interferensmodulerad flödescytometri
- 2015
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Projektet har utvärderat ny mätteknik för att man snabbare ska kunna upptäcka påverkan av fekalier på råvatten. E. coli har använts som indikatorbakterie. Det använda instrumentet har stor potential att mäta halten E.colii råvatten online, och lämpar sig därför bra som ett tidigt varningssystem.Online-mätning av råvattenkvaliteten kan förhindra vattenburen smitta,något som är intressant för både dricksvattenproducenter och samhället istort.Metoden baseras på att bakterier märks med antikroppar som har fluorescenstaggats med en molekyl som gör att de efter bestrålning sänder utkortvarigt ljus. Ett optiskt instrument har utvecklats för att räkna enstakabakterier i ett provflöde. Mätsystemet har konstruerats för att dels matchaen industriell miljö, dels hålla nere kostnaden för att göra instrumentet ekonomiskt rimligt för aktörer inom dricksvattenproduktionDe fluorescerande markörerna skickar ut ljus som uppfångas av en detektor. Ursprungligen valdes markörerna för att skicka ut ljus i det synliga området. Men det visade sig att bakgrundsfluorescensen i det synliga området varhög, från klorofyll i alger och cyanobakterier. Därför beslutade projektgruppen att i stället välja markörer som fluorescerade i nära infraröda våglängder.Bytet av våglängdsområde löste problemen med bakgrundsfluorescens ochär ett avgörande steg mot ett fungerande instrument. Men anpassningen avoptiken för det nya våglängdsområdet medförde nya utmaningar, särskilt pådetektorsidan.Fälttester som genomfördes på Överby Vattenverk i Trollhättan visade attinstrumentet fungerar bra i den industriella miljön, och man kunde kopplain det mot en råvattenledning. Mätningar utförda i labb på råvatten ochrenat avloppsvatten visade på tydliga skillnader i koncentrationen av E. coli,men i de flesta fall var den uppmätta halten lägre än förväntat.Den kanske största begränsningen med den nya mättekniken är att få entillräckligt hög genomströmning av vattenprov i instrumentet. Detta är viktigt för att få en bra uppskattning av koncentrationen E. coli inom rimlig tid(minuter). Man kan öka genomflödet genom att öka dimensionen hos denoptiska flödeskanalen. Nackdelen är att känsligheten minskar. I en störreflödeskanal tittar man på ett större område och signalen från en enstakabakterie gentemot bakgrunden blir mindre. Här finns en viktig avvägningför framtida utveckling.Projektet har letts av Trollhättan Energi i samarbete med Göteborgs stad,Norrvatten, Vivab och DRICKS-programmet på Chalmers. Större delen avutvecklingsarbetet har utförts av Acreo Swedish ICT. Projektet har ingåttsom en del i ett större Vinnovafinansierat projekt inom utmaningsdriveninnovation med titeln Online sensorsystem för resurseffektiv vattenhantering (SENSATION) som avslutades 2014 och var fokuserat på en helhetslösning för mätning av vattenkvalitet.
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