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| 2. |
- Bourennane, Mohamed, et al.
(författare)
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Experimental long wavelength quantum cryptography: from single-photon transmission to key extraction protocols
- 2000
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Ingår i: Journal of Modern Optics. - : Informa UK Limited. - 0950-0340 .- 1362-3044. ; 47, s. 563-579
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Tidskriftsartikel (refereegranskat)abstract
- We present experiments on long wavelength (λ = 1.55 μm) 'plug and play' quantum cryptography systems. We discuss the performance of single-photon detectors at λ = 1.55 μm. Furthermore, we address the full implementation of the quantum cryptography protocol, discussing in detail the implementation of protocols for error correction and privacy amplification needed to get a secure key. We illustrate the theory with examples from a full software simulation to show the performance of the complete protocol in terms of final secure key creation rate
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| 3. |
- Brorsson, Ann-Christin, 1969-
(författare)
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The Folding Energy Landscape of MerP
- 2004
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis is based on studies, described in four papers, in which the folding energy landscape of MerP was investigated by various techniques. MerP is a water-soluble 72 amino acid protein with a secondary structure consisting of four anti-parallel β-strands and two α-helices on one side of the sheet in the order β1α1β2β3α2β4.The first paper describes the use of CD and fluorescence analysis to examine the folding/unfolding process of MerP. From these experiments it was found that the protein folds according to a two-state model in which only the native and unfolded forms are populated without any visible intermediates. With a rate constant of 1.2 s-1, the folding rate was found to be unusually slow for a protein of this size.The studies presented in the second and third papers were based on measurements of native-state amide proton exchange at different temperatures (Paper II) and GuHCl concentrations (Paper III) in the pre-transitional region. In these studies partially unfolded forms were found for MerP which are essentially unrelated to each other. Thus, in the folding energy landscape of MerP, several intermediates seem to occur on different folding trajectories that are parallel to each other. The slow folding rate of MerP might be coupled to extensive visitation of these conformations. Hydrogen exchange in MerP did also reveal structure-dependent differences in compactness between the denatured states in GuHCl and H2O.In the last paper multivariate data analysis was applied to 2-dimensional NMR data to detect conformational changes in the structure of MerP induced by GuHCl. From this analysis it was suggested that regions involved in the most flexible part of the protein structure are disrupted at rather low denaturant concentrations (< 2.1 M GuHCl) while the native structures of the most stable parts are still not completely ruptured at 2.9 M GuHCl.Finally, the stability, kinetics, contact order and folding nuclei of six proteins with similar topology (MerP, U1A, S6, ADA2h, AcP and HPr) were compared. In this analysis it was found that their folding properties are quite diverse, despite their topological similarities, and no general rules that have been formulated yet can adequately predict their folding behaviour.
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| 4. |
- Hallencreutz, Daniel
(författare)
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Populärmusik, kluster och industriell konkurrenskraft : En ekonomisk-geografisk studie av svensk musikindustri
- 2002
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The economic importance of design-intensive and cultural-products industries has grown in recent decades. One case in point is Sweden, where internationally competitive industries have emerged in areas such as multimedia, fashion, and music. During the 1990s, research in economic geography and related disciplines concerned with the link between geographical location and competitive advantage has found an important source of inspiration in the cluster approach. The thesis examines the relationship between spatial clustering and industrial competitive-ness by undertaking a series of empirical studies that explore various dimensions of the Swedish music industry. The thesis demonstrates that the Swedish music industry embraces a multitude of actors in a complex, spatially clustered production system characterised by dense social networks, which transcend individual firms. Processes and mechanisms that have enhanced the creation and diffusion of strategic knowledge as well as co-operative competition further promote the competitiveness of this cluster. Moreover, the thesis demonstrates that it is necessary to carefully consider the relation between the local milieu and the global music industrial production and distribution system in order to fully understand competitiveness in the music industry. Finally, the thesis examines how the cluster concept has been put into practice in Swedish industrial and regional policies concerning cultural industries.
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| 5. |
- Hirschberg, Daniel, et al.
(författare)
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N-terminal acetylation in a third protein family of vertebrate alcohol dehydrogenase/retinal reductase found through a 'proteomics' approach in enzyme characterization.
- 2001
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Ingår i: Cellular and Molecular Life Sciences (CMLS). - 1420-682X .- 1420-9071. ; 58:9
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Tidskriftsartikel (refereegranskat)abstract
- A recent finding of a novel class of retinol-active alcohol dehydrogenase (ADH) in frog prompted analysis of this activity in other vertebrate forms. Surprisingly, yet another and still more unrelated ADH was identified in chicken tissues. It was found to be a member of the aldo-keto reductase (AKR) enzyme family, not previously known as an ADH in vertebrates. Its terminal blocking group and the N-terminal segment, not assigned by protein and cDNA structure analysis, were determined by electrospray tandem mass spectrometry after protein isolation by two-dimensional gel electrophoresis. The N terminus is Acetyl-Ala- and the N-terminal segment contains two consecutive Asn residues. The results establish the new ADH enzyme of the AKR family and show the usefulness of combined gel separation and mass spectrometry in enzyme-characterization.
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| 6. |
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| 7. |
- Jonsson, Andreas P., et al.
(författare)
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Minute quantities of misfolded mutant superoxide dismutase-1 cause amyotrophic lateral sclerosis
- 2004
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Ingår i: Brain. - : Oxford University Press. - 0006-8950 .- 1460-2156. ; 127:Pt 1, s. 73-88
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Tidskriftsartikel (refereegranskat)abstract
- Mutant forms of superoxide dismutase-1 (SOD1) cause amyotrophic lateral sclerosis (ALS) by an unknown noxious mechanism. Using an antibody against a novel epitope in the G127insTGGG mutation, mutant SOD1 was studied for the first time in spinal cord and brain of an ALS patient. The level was below 0.5% of the SOD1 level in controls. In corresponding transgenic mice the content of mutant SOD1 was also low, although it was enriched in spinal cord and brain compared with other tissues. In the mice the misfolded mutant SOD1 aggregated rapidly and 20% occurred in steady state as detergent-soluble protoaggregates. The misfolded SOD1 and the protoaggregates form, from birth until death, a potentially noxious burden that may induce the motor neuron injury. Detergent-resistant aggregates, as well as inclusions of mutant SOD1 in motor neurons and astrocytes, accumulated in spinal cord ventral horns of the patient and mice with terminal disease. The inclusions and aggregates may serve as terminal markers of long-term assault by misfolded SOD1 and protoaggregates.
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