| 1. |
- Gaita, Samuel Mwaniki, 1976, et al.
(author)
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Characterization of Size-Fractionated Particulate Matter and Deposition Fractions in Human Respiratory System in a Typical African City: Nairobi, Kenya
- 2016
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In: Aerosol and Air Quality Research. - : Taiwan Association for Aerosol Research. - 2071-1409 .- 1680-8584. ; 16:10, s. 2378-2385
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Journal article (peer-reviewed)abstract
- Information from elemental and mass composition of size-fractionated airborne particle matter (PM) provides insightfulknowledge about their impact on human health, meteorology and climate. To attain insight into the nature of sizefractionatedPM from a typical African city, samples were collected from an urban background site in Nairobi, Kenya,during the months of August and September in 2007. PM samples ranging in size from 0.06 to 16 µm aerodynamicdiameter were collected on pre-weighed polycarbonate filters with 0.4 µm pore size using a nine-stage cascade impactor.Particles less than 0.06 µm were collected on a backup filter. A total of 170 samples were collected and analysed for traceelements using the Proton Induced X-Ray Emission (PIXE) technique. The analysis showed that Si, Fe and S dominated inall size ranges and displayed unimodal mass-size distribution whereas K, Cu, Zn and Pb, depicted bimodal mass-sizedistribution highlighting the multiplicity of their sources. To estimate human exposure to PM, deposition fractions of boththe coarse and fine PM in the human respiratory system were calculated. The deposited concentration was found to behighest in the head airways region compared to the tracheobronchial and pulmonary regions.
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| 2. |
- Högdahl, Karin, et al.
(author)
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Ore mineralogy, trace element distribution and 3D X-ray tomography of the polymetallic sulphide deposits at Mavres Petres and Piavitsa, Greece
- 2019
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In: LIFE WITH ORE DEPOSITS ON EARTH, PROCEEDINGS OF THE 15TH SGA BIENNIAL MEETING, 2019, VOLS 1-4. - : SOC GEOLOGY APPLIED MINERAL DEPOSITS-SGA. - 9780852619629 ; , s. 279-282
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Conference paper (peer-reviewed)abstract
- The Mavres Petres mine, operated by Hellas Gold, and the Piavitsa prospect are both located along the Stratoni fault in the Kassandra mining district, northern Greece. These Tertiary deposits are brecciated, carbonate replacement Pb-Zn-Ag-(Au) mineralisations and the Piavitsa deposit is also associated with Au-rich epithermal veins. Both mineralisations were variably overprinted by later fluids as well as ductile and brittle deformation affecting ore mineralogy and trace element distribution. Galena is the main Ag-carrier, contains significant concentrations of Sb and Bi and is locally associated with a suite of Sb-As-Bi phases. Sphalerite is either massive or occurs as a later cockade-textured type. Both varieties are variably enriched in Mn and can exhibit elevated concentrations of In and Ga. In Piavitsa, alabandite is present as small euhedral crystals or in veins in fractured sphalerite. Pyrite is ubiquitous and is either present as disseminations, massive to skeletal aggregates or as a matrix in breccias. It is often arsenic-bearing and even more so towards the later stages. Arsenopyrite appears to be a late phase and occurs interstitial to pyrite and as euhedral crystals. While both arsenopyrite and arsenian pyrite can be enriched in Au, As-minerals are not necessarily associated with Au.
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| 3. |
- Kottyan, Leah C., et al.
(author)
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The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share.
- 2015
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In: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 24:2, s. 582-596
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Journal article (peer-reviewed)abstract
- Exploiting genotyping, DNA sequencing, imputation and trans-ancestral mapping, we used Bayesian and frequentist approaches to model the IRF5-TNPO3 locus association, now implicated in two immunotherapies and seven autoimmune diseases. Specifically, in systemic lupus erythematosus (SLE), we resolved separate associations in the IRF5 promoter (all ancestries) and with an extended European haplotype. We captured 3230 IRF5-TNPO3 high-quality, common variants across 5 ethnicities in 8395 SLE cases and 7367 controls. The genetic effect from the IRF5 promoter can be explained by any one of four variants in 5.7 kb (P-valuemeta = 6 × 10(-49); OR = 1.38-1.97). The second genetic effect spanned an 85.5-kb, 24-variant haplotype that included the genes IRF5 and TNPO3 (P-valuesEU = 10(-27)-10(-32), OR = 1.7-1.81). Many variants at the IRF5 locus with previously assigned biological function are not members of either final credible set of potential causal variants identified herein. In addition to the known biologically functional variants, we demonstrated that the risk allele of rs4728142, a variant in the promoter among the lowest frequentist probability and highest Bayesian posterior probability, was correlated with IRF5 expression and differentially binds the transcription factor ZBTB3. Our analytical strategy provides a novel framework for future studies aimed at dissecting etiological genetic effects. Finally, both SLE elements of the statistical model appear to operate in Sjögrens syndrome and systemic sclerosis whereas only the IRF5-TNPO3 gene-spanning haplotype is associated with primary biliary cirrhosis, demonstrating the nuance of similarity and difference in autoimmune disease risk mechanisms at IRF5-TNPO3.
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| 4. |
- Wiberg, Rebecca, 1988-, et al.
(author)
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Investigation of the Expression of Myogenic Transcription Factors, microRNAs and Muscle-Specific E3 Ubiquitin Ligases in the Medial Gastrocnemius and Soleus Muscles following Peripheral Nerve Injury
- 2015
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In: PLOS ONE. - San Francisco : Public Library Science. - 1932-6203. ; 10:12
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Journal article (peer-reviewed)abstract
- Despite surgical innovation, the sensory and motor outcome after a peripheral nerve injury remains incomplete. One contributing factor to the poor outcome is prolonged denervation of the target organ, leading to apoptosis of both mature myofibres and satellite cells with subsequent replacement of the muscle tissue with fibrotic scar and adipose tissue. In this study, we investigated the expression of myogenic transcription factors, muscle specific microRNAs and muscle-specific E3 ubiquitin ligases at several time points following denervation in two different muscles, the gastrocnemius (containing predominantly fast type fibres) and soleus (slow type) muscles, since these molecules may influence the degree of atrophy following denervation. Both muscles exhibited significant atrophy (compared with the contra-lateral sides) at 7 days following either a nerve transection or crush injury. In the crush model, the soleus muscle showed significantly increased muscle weights at days 14 and 28 which was not the case for the gastrocnemius muscle which continued to atrophy. There was a significantly more pronounced up-regulation of MyoD expression in the denervated soleus muscle compared with the gastrocnemius muscle. Conversely, myogenin was more markedly elevated in the gastrocnemius versus soleus muscles. The muscles also showed significantly contrasting transcriptional regulation of the microRNAs miR-1 and miR-206. MuRF1 and Atrogin-1 showed the highest levels of expression in the denervated gastrocnemius muscle. This study provides further insights regarding the intracellular regulatory molecules that generate and maintain distinct patterns of gene expression in different fibre types following peripheral nerve injury.
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