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Whole-body 11C-5-hy...
Whole-body 11C-5-hydroxytryptophan positron emission tomography as a universal imaging technique for neuroendocrine tumors : Comparison with somatostatin receptor scintigraphy and computed tomography
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- Örlefors, Håkan (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala University
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- Sundin, Anders (författare)
- Uppsala universitet,Enheten för radiologi,Uppsala University
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- Garske, Ulrike (författare)
- Uppsala universitet,Enheten för radiologi,Uppsala University
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- Juhlin, Claes, 1952- (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Uppsala University
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- Öberg, Kjell (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Onkologisk endokrinologi,Kjell Öberg,Uppsala University
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- Skogseid, Britt (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Endokrin tumörbiologi,Britt Skogseid,Uppsala University
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- Långstrom, Bengt (författare)
- Uppsala universitet,Plattformen för preklinisk PET,Uppsala University
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- Bergström, M (författare)
- Uppsala universitet,Plattformen för preklinisk PET,Uppsala University
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- Eriksson, Barbro (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala University
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(creator_code:org_t)
- The Endocrine Society, 2005
- 2005
- Engelska.
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Ingår i: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 90:6, s. 3392-3400
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https://academic.oup...
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Neuroendocrine tumors (NETs) can be small and situated almost anywhere throughout the body. Our objective was to investigate whether whole-body (WB) positron emission tomography (PET) with 11C-5-hydroxytryptophan (5-HTP) can be used as a universal imaging technique for NETs and to compare this technique with established imaging methods. Forty-two consecutive patients with evidence of NET and a detected lesion on any conventional imaging (six bronchial, two foregut, 16 midgut, and two thymic carcinoids; one ectopic Cushing’s syndrome; four gastrinomas; one insulinoma; six nonfunctioning endocrine pancreatic tumors; one gastric carcinoid, one paraganglioma; and two endocrine-differentiated pancreatic carcinomas) were studied. The WB-11C-5-HTP-PET examinations were compared with WB-computed tomography (CT) and somatostatin receptor scintigraphy (SRS). Tumor lesions were imaged with PET in 95% of the patients. In 58% of the patients, PET could detect more lesions than SRS and CT and equal numbers in 34%, whereas in three cases, SRS or CT showed more lesions. In 84% (16 of 19 patients), PET could visualize the primary tumor compared with 47 and 42% for SRS and CT, respectively. The surgically removed PET-positive primary tumor sizes were 6–30 mm. To conclude, this study indicates that WB-11C-5-HTP-PET can be used as a universal imaging method for detection of NETs. This study also shows that WB-11C-HTP-PET is sensitive in imaging small NET lesions, such as primary tumors, and can in a majority of cases image significantly more tumor lesions than SRS and CT.
Nyckelord
- MEDICINE
- MEDICIN
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- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Örlefors, Håkan
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Sundin, Anders
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Garske, Ulrike
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Juhlin, Claes, 1 ...
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Öberg, Kjell
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Skogseid, Britt
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visa fler...
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Långstrom, Bengt
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Bergström, M
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Eriksson, Barbro
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Uppsala universitet