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- Ehnhage, A, et al.
(författare)
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Nasal and bronchial histamine responsiveness in pollen-exposed patients with seasonal rhinitis
- 2002
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Ingår i: ORL. - : S. Karger AG. - 0301-1569 .- 1423-0275. ; 64:3, s. 191-199
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Tidskriftsartikel (refereegranskat)abstract
- In a previous study, we found an increased nasal responsiveness as measured by rhinostereometry and histamine challenge out of season in a sample of 12 patients suffering mainly from hay fever. The aim of the present study was to investigate whether airway responsiveness in these patients was further increased after direct pollen exposure, after a single nasal pollen provocation as well as by repeated exposure during the pollen season. In spite of increased allergic symptoms, the basal degree of nasal mucosal swelling was unchanged before histamine challenge under these circumstances. After histamine challenge, nasal mucosal swelling was increased in the same way over the seasons. Also bronchial responsiveness was unchanged during the pollen season. It correlated to frequent sneezing following nasal histamine challenge during the season (p = 0.0071, r = –0.74). We interpret the results as an indication of a continuos airway inflammation regardless of season in these patients with pollen allergy, with acute symptoms added on direct exposure to the allergen.
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| 7. |
- Sundström, P, et al.
(författare)
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An altered immune response to Epstein-Barr virus in multiple sclerosis : a prospective study
- 2004
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Ingår i: Neurology. - : Aan publication. - 0028-3878 .- 1526-632X. ; 62:12, s. 2277-82
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To investigate the association between human herpesviruses and multiple sclerosis (MS), as well as between measles virus and MS.Methods: The authors identified prospectively collected serum samples from 73 MS cases and retrospective sera from 161 MS cases in two population-based serum bank registers. Analyses of IgG antibody responses in cases and matched referents were performed for Epstein-Barr virus (EBV [EBNA-1 and VCA]), human herpesvirus 6 (HHV-6), herpes simplex virus (HSV), varicella zoster virus (VZV), and measles.Results: All cases showed signs of past EBV infection. High activity to EBNA-1 and HHV-6 significantly (borderline significance for HHV-6) increased the risk for MS in prospective sera. A discrepancy between activities to EBNA-1 and VCA was striking in MS samples collected less than 5 years before relapsing-remitting MS onset, where high activity to EBNA-1 significantly increased, and high VCA activity significantly decreased the risk for MS. There was no support for major causal roles for HSV, VZV, or measles.Conclusion: Individuals who will develop MS exhibit an altered immune response against the EBV virus characterized by a high IgG activity to EBNA-1 in the absence of high activity to VCA, this being most pronounced in the 5-year period preceding MS onset.
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