SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(KARRE K) srt2:(2005-2009)"

Sökning: WFRF:(KARRE K) > (2005-2009)

  • Resultat 1-10 av 23
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  •  
3.
  •  
4.
  •  
5.
  •  
6.
  • Branner, H, et al. (författare)
  • NK cells in type 1 diabetes
  • 2007
  • Ingår i: DIABETOLOGIA. - 0012-186X. ; 50, s. S190-S190
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)
  •  
7.
  •  
8.
  •  
9.
  • Brodin, P, et al. (författare)
  • The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells
  • 2009
  • Ingår i: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 113:11, s. 2434-2441
  • Tidskriftsartikel (refereegranskat)abstract
    • Natural killer (NK) cells express inhibitory receptors for major histocompatibility complex (MHC) class I. If self-MHC is down-regulated or absent, lack of inhibition triggers “missing self” killing. NK cells developing in the absence of MHC class I are hypo-responsive, demonstrating that MHC class I molecules are required for NK-cell education. Here, we show that the number and the type of MHC class I alleles that are present during NK-cell education quantitatively determine the frequency of responding NK cells, the number of effector functions in individual NK cells, and the amount of interferon-γ production in NK cells of specific Ly49 subsets. A relationship between the extent of inhibitory signals during education and functional responsiveness was corroborated by an enhanced probability of NK cells expressing more than one inhibitory receptor for a single host self–MHC class I allele to degranulate after activation. Our data suggest that the capacity of an individual NK cell to respond to stimulation is quantitatively controlled by the extent of inhibitory signals that are received from MHC class I molecules during NK-cell education.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 23

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy