| 1. |
- Adcox, K, et al.
(author)
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PHENIX detector overview
- 2003
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In: Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment. - 0167-5087. ; 499:2-3, s. 469-479
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Journal article (peer-reviewed)abstract
- The PHENIX detector is designed to perform a broad study of A-A, p-A, and p-p collisions to investigate nuclear matter under extreme conditions. A wide variety of probes, sensitive to all timescales, are used to study systematic variations with species and energy as well as to measure the spin structure of the nucleon. Designing for the needs of the heavy-ion and polarized-proton programs has produced a detector with unparalleled capabilities. PHENIX measures electron and muon pairs, photons, and hadrons with excellent energy and momentum resolution. The detector consists of a large number of subsystems that are discussed in other papers in this volume. The overall design parameters of the detector are presented. (C) 2002 Elsevier Science B.V. All rights reserved.
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| 2. |
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| 3. |
- Kahn, J, et al.
(author)
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Overexpression of CXCR4 on human CD34(+) progenitors increases their proliferation, migration, and NOD/SCID repopulation
- 2004
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In: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 103:8, s. 2942-2949
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Journal article (peer-reviewed)abstract
- A major limitation to clinical stem cell-mediated gene therapy protocols is the low levels of engraftment by transduced progenitors. We report that CXCR4 overexpression on human CD34(+) progenitors using a lentiviral gene transfer technique helped navigate these cells to the murine bone marrow and spleen in response to stromal-derived factor 1 (SDF-1) signaling. Cells overexpressing CXCR4 exhibited significant increases in SDF-1-mediated chemotaxis and actin polymerization compared with control cells. A major advantage of CXCR4 overexpression was demonstrated by the ability of transduced CD34(+) cells to respond to lower, physiologic levels of SDF-1 when compared to control cells, leading to improved SDIF-1-induced migration and proliferation/survival, and finally resulting in significantly higher levels of in vivo repopulation of nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mice including primitive CD34(+)/CD38(-/low) cells. Importantly, no cellular transformation was observed following transduction with the CXCR4 vector. Unexpectedly, we documented lack of receptor internalization in response to high levels of SDF-1, which can also contribute to increased migration and proliferation by the transduced CD34(+) cells. Our results suggest CXCR4 overexpression for improved definitive human stem cell motility, retention, and multilineage repopulation, which could be beneficial for in vivo navigation and expansion of hematopoietic progenitors.
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| 4. |
- Kahn, Joel S., et al.
(author)
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Anthropology and Modernity1/Comments/Reply
- 2001
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In: Current Anthropology. ; 42:5
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Journal article (peer-reviewed)abstract
- Â Against those who have taken anthropologists to task for flirting with the "meta-narratives" of modernity, this article argues that it is incumbent on them to engage with both modernity and modernist narratives far more directly and explicitly than in the past. This holds even, or especially, for those who, in positing a notion of multiple modernities, have managed to hold modernist narrative at arm’s length, neglecting the potential fruitfulness of juxtaposing Western and non-Western experiences of what Habermas has called the project of modernity. The encounter between anthropology and modernity is generated on the one hand by changes in the lives of the subjects of ethnographic research, but the fact of these changes raises more searching questions about whether ethnographers ever studied genuinely premodern peoples and cultures. The reflexive imperative, moreover, confirms the need to recognize anthropology’s own modernist origins. Finally it is argued that it is critical modernist theory in the Hegel-Marx-Weber tradition that is the most pertinent to the ethnographic encounter and that the exercise of bringing together critical theory and ethnographic knowledge, while conflictual, produces fruitful results for both sides. [PUBLICATION ABSTRACT]
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| 5. |
- Selten, JP, et al.
(author)
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No relationship between risk of schizophrenia and prenatal exposure to stress during the Six-Day War or Yom Kippur War in Israel
- 2003
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In: Schizophrenia Research. - 0920-9964. ; 63:1-2, s. 131-135
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Journal article (peer-reviewed)abstract
- Aim: Maternal stress during pregnancy is a possible risk factor for schizophrenia in the offspring. Using data from the Israel Psychiatric Registry we examined the impact of wars in Israel. Method: Retrospective birth cohort study. Results: Relative risks for cohorts exposed to Six-Day War and Yom Kippur War were 0.98 (95% CI: 0.85-1.13) and 1.00 (0.86-1.16). Conclusion: The evidence for maternal stress as a risk factor for schizophrenia remains insufficient. (C) 2002 Elsevier Science B.V. All rights reserved.
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