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- Bjerre, Lise M., et al.
(författare)
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Assessing potentially inappropriate prescribing (PIP) and predicting patient outcomes in Ontario's older population : a population-based cohort study applying subsets of the STOPP/START and Beers' criteria in large health administrative databases
- 2015
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Ingår i: BMJ Open. - : BMJ. - 2044-6055. ; 5:11
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Adverse drug events (ADEs) are common in older people and contribute significantly to emergency department (ED) visits, unplanned hospitalisations, healthcare costs, morbidity and mortality. Many ADEs are avoidable if attention is directed towards identifying and preventing inappropriate drug use and undesirable drug combinations. Tools exist to identify potentially inappropriate prescribing (PIP) in clinical settings, but they are underused. Applying PIP assessment tools to population-wide health administrative data could provide an opportunity to assess the impact of PIP on individual patients as well as on the healthcare system. This would open new possibilities for interventions to monitor and optimise medication management on a broader, population-level scale. Methods and analysis: The aim of this study is to describe the occurrence of PIP in Ontario's older population (aged 65 years and older), and to assess the health outcomes and health system costs associated with PIP-more specifically, the association between PIP and the occurrence of ED visits, hospitalisations and death, and their related costs. This will be done within the framework of a population-based retrospective cohort study using Ontario's large health administrative and population databases. Eligible patients aged 66 years and older who were issued at least 1 prescription between 1 April 2003 and 31 March 2014 (approximately 2 million patients) will be included. Ethics and dissemination: Ethical approval was obtained from the Ottawa Health Services Network Ethical Review Board and from the Bruyere Research Institute Ethics Review Board. Dissemination will occur via publication, presentation at national and international conferences, and ongoing exchanges with regional, provincial and national stakeholders, including the Ontario Drug Policy Research Network and the Ontario Ministry of Health and Long-Term Care.
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- Kormi-Nouri, Reza, 1954-
(författare)
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The role of movement and object in action memory: a comparative study between blind, blindfolded and sighted subjects
- 2000
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Ingår i: Scandinavian Journal of Psychology. - : Blackhorse Publishing. - 0036-5564 .- 1467-9450. ; 41:1, s. 71-75
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Tidskriftsartikel (refereegranskat)abstract
- Two experiments systematically compared four SPT conditions involving real-imaginary movement and real-imaginary object with one VT condition involving no enactment and no object. To test the effect of visual information on SPT memory, sighted subjects were compared with blindfolded subjects (in Experiment 1) and blind subjects (in Experiment 2). All subjects learned all SPTs and VTs. Free recall data showed no difference between the SPT conditions and between the groups of subjects; only blind subjects were found to be limitedin the use of visualization strategy. All SPTs were recalled better than VTs, indicating that the enactment effect is not determined by either movement or object alone, rather both have an effective role and are equally involved for obtaining the enactment effect. The results provideno support for the motor encoding and multimodality views of SPTs, but are in line with the episodic integration view which assumes that neither movement nor object are of special importance, rather both have contribution in the enactment effect.
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- Peeker, Ralph, 1958
(författare)
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Ureteric reconstruction and replacement.
- 2009
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Ingår i: Current opinion in urology. - 1473-6586.
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE OF REVIEW: To review the recent advances on ureteric reconstruction and replacement, in particular, ileal ureteric replacement and laparoscopic and robotic-assisted ureteral reconstruction. RECENT FINDINGS: Recently, the ureteric replacement with bowel has been carefully assessed by several authors, and the results are quite impressive. Also, very recent studies on laparoscopic and robotic-assisted ureteral repair have been published. Outcomes appear very promising, allowing for a faster recovery and shorter hospital stay for the patient. SUMMARY: Today, we can conclude that the field of ureteric reconstruction and replacement is still evolving. Old techniques are supported by an increasing degree of evidence, and new, more minimally invasive surgical strategies emerge. Clearly, there are some disadvantages as well as difficulties to overcome with the new techniques; however, recent studies appear to present promising results.
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- Ågård, A, et al.
(författare)
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Patients' experiences of intervention trials treatment of myocardial infarction : is it time to adjust the informed consent procedure to the patient's capacity?
- 2001
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Ingår i: Heart. - : BMJ Group. - 1355-6037 .- 1468-201X .- 0007-0769. ; 86:6, s. 632-637
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE—To investigate how patients included in trials on treatment in the early phase of acute myocardial infarction experience the consent procedure. DESIGN—A combined qualitative and quantitative interview concerning the patients' knowledge of the trial, their feelings about being asked to participate, and their attitudes towards the consent procedure. SETTING—Tertiary referral centre. PATIENTS—31 patients who had given written informed consent for their participation in randomised intervention trials of acute myocardial infarction. RESULTS—The patients interviewed had only fragmentary knowledge about the trial they were involved in. Most considered that reading and signing a consent form was an unwanted or unnecessary procedure. Instead, they would have preferred to have been given concise verbal information about the study. Most were willing to allow a physician to decide for them in the event of their being too ill to be asked about their participation. CONCLUSIONS—Patients who are asked to participate in intervention trials in the early phase of acute myocardial infarction often appear to lack sufficient knowledge to reach an autonomous choice. There were problems and disadvantages associated with the process of obtaining written informed consent in this particular situation, especially regarding the need for the patient to sign a consent form during the acute phase of the disease.
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