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Sökning: WFRF:(Kalinichenko A) > (2015-2019)

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  • Serwas, NK, et al. (författare)
  • Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis
  • 2019
  • Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 3106-
  • Tidskriftsartikel (refereegranskat)abstract
    • Immune responses need to be controlled tightly to prevent autoimmune diseases, yet underlying molecular mechanisms remain partially understood. Here, we identify biallelic mutations in three patients from two unrelated families in differentially expressed in FDCP6 homolog (DEF6) as the molecular cause of an inborn error of immunity with systemic autoimmunity. Patient T cells exhibit impaired regulation of CTLA-4 surface trafficking associated with reduced functional CTLA-4 availability, which is replicated in DEF6-knockout Jurkat cells. Mechanistically, we identify the small GTPase RAB11 as an interactor of the guanine nucleotide exchange factor DEF6, and find disrupted binding of mutant DEF6 to RAB11 as well as reduced RAB11+CTLA-4+ vesicles in DEF6-mutated cells. One of the patients has been treated with CTLA-4-Ig and achieved sustained remission. Collectively, we uncover DEF6 as player in immune homeostasis ensuring availability of the checkpoint protein CTLA-4 at T-cell surface, identifying a potential target for autoimmune and/or cancer therapy.
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  • Silveira, Semida, 1961-, et al. (författare)
  • Opportunities for bioenergy in the Baltic Sea Region
  • 2017
  • Ingår i: International Scientific Conference “Environmental and Climate Technologies”, CONECT 2017, 10-12 May 2017, Riga, Latvia. - : Elsevier. ; , s. 157-164
  • Konferensbidrag (refereegranskat)abstract
    • Security of energy supply, promotion of the bio-economy, nutrient recycling, and innovation are prioritized policy areas in the EU Strategy for the Baltic Sea Region (EUBSR). The Baltic Sea Region (BSR) has a great bioenergy potential worth exploring in this context. This paper explores the state-of-art of bioenergy systems and synergies with eco-systems services in the BSR region in the context of developing the region's bio-economy. In this brief assessment, we consider 8 countries (i.e. Sweden, Finland, Estonia, Latvia, Lithuania, Poland, Denmark, and Belarus) in the region. While the production and use of modern bioenergy can help reduce greenhouse gas (GHG) emissions, promote energy security, diversify energy resources, and contribute to a successful circular economy and rural development, it is important to find a balance between the exploration of resources and the management of eco-systems services. In addition, both climate change vulnerability and bioenergy production may affect the environment and the capacity of the BSR to deliver ecosystem services (ESS). We recommend integrated strategies for optimal use of bioresources in the region. Bioeconomy can be realized by innovative approaches, establishing cross-cutting institutional and policy linkages for increased prosperity and green growth in the Baltic Sea Region.
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