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- Yu, X., et al.
(författare)
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Association of UCP2 - 866 G/A polymorphism with chronic inflammatory diseases
- 2009
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Ingår i: Genes and Immunity. - : Springer Science and Business Media LLC. - 1466-4879 .- 1476-5470. ; 10:6, s. 601-605
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Tidskriftsartikel (refereegranskat)abstract
- We reported earlier that two mitochondrial gene polymorphisms, UCP2 -866 G/A (rs659366) and mtDNA nt13708 G/A (rs28359178), are associated with multiple sclerosis (MS). Here we aim to investigate whether these functional polymorphisms contribute to other eight chronic inflammatory diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Wegener' granulomatosis (WG), Churg-Strauss syndrome (CSS), Crohn's disease (CD), ulcerative colitis (UC), primary sclerosing cholangitis (PSC) and psoriasis. Compared with individual control panels, the UCP2 -866 G/A polymorphism was associated with RA and SLE, and the mtDNA nt13708 G/A polymorphism with RA. Compared with combined controls, the UCP2 -866 G/A polymorphism was associated with SLE, WG, CD and UC. When all eight disease panels and the original MS panel were combined in a meta-analysis, the UCP2 was associated with chronic inflammatory diseases in terms of either alleles (odds ratio (OR)=0.91, 95% confidence interval (95% CI): 0.86-0.96), P=0.0003) or genotypes (OR=0.88, (95% CI: 0.82-0.95), P=0.0008), with the -866A allele associated with a decreased risk to diseases. As the -866A allele increases gene expression, our findings suggest a protective role of the UCP2 protein in chronic inflammatory diseases.
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| 2. |
- Beck, P S A, et al.
(författare)
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A ground-validated NDVI dataset for monitoring vegetation dynamics and mapping phenology in Fennoscandia and the Kola peninsula
- 2007
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Ingår i: International Journal of Remote Sensing. - : Informa UK Limited. - 1366-5901 .- 0143-1161. ; 28:19, s. 4311-4330
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Tidskriftsartikel (refereegranskat)abstract
- An NDVI dataset covering Fennoscandia and the Kola peninsula was created for vegetation and climate studies, using Moderate Resolution Imaging Spectroradiometer 16-day maximum value composite data from 2000 to 2005. To create the dataset, ( 1) the influence of the polar night and snow on the NDVI values was removed by replacing NDVI values in winter with a pixel- specific NDVI value representing the NDVI outside the growing season when the pixel is free of snow; and ( 2) yearly NDVI time series were modelled for each pixel using a double logistic function defined by six parameters. Estimates of the onset of spring and the end of autumn were then mapped using the modelled dataset and compared with ground observations of the onset of leafing and the end of leaf fall in birch, respectively. Missing and poor-quality data prevented estimates from being produced for all pixels in the study area. Applying a 5 km x 5 km mean filter increased the number of modelled pixels without decreasing the accuracy of the predictions. The comparison shows good agreement between the modelled and observed dates ( root mean square error = 12 days, n = 108 for spring; root mean square error = 10 days, n = 26, for autumn). Fennoscandia shows a range in the onset of spring of more than 2 months within a single year and locally the onset of spring varies with up to one month between years. The end of autumn varies by one and a half months across the region. While continued validation with ground data is needed, this new dataset facilitates the detailed monitoring of vegetation activity in Fennoscandia and the Kola peninsula.
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| 8. |
- Rønn, SG, et al.
(författare)
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Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejection
- 2008
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Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 51:10, s. 1873-1882
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Tidskriftsartikel (refereegranskat)abstract
- Aims/hypothesis The pro-inflammatory cytokines IL-1 and IFN gamma are critical molecules in immune-mediated beta cell destruction leading to type 1 diabetes mellitus. Suppressor of cytokine signalling (SOCS)-3 inhibits the cytokine-mediated destruction of insulinoma-1 cells. Here we investigate the effect of SOCS3 in primary rodent beta cells and diabetic animal models. Methods Using mice with beta cell-specific Socs3 expression and a Socs3-encoding adenovirus construct, we characterised the protective effect of SOCS3 in mouse and rat islets subjected to cytokine stimulation. In transplantation studies of NOD mice and alloxan-treated mice the survival of Socs3 transgenic islets was investigated. Results Socs3 transgenic islets showed significant resistance to cytokine-induced apoptosis and impaired insulin release. Neither glucose-stimulated insulin release, insulin content or glucose oxidation were affected by SOCS3. Rat islet cultures transduced with Socs3-adenovirus displayed reduced cytokine-induced nitric oxide and apoptosis associated with inhibition of the IL-1-induced nuclear factor-kappa B and mitogen-activated protein kinase (MAPK) pathways. Transplanted Socs3 transgenic islets were not protected in diabetic NOD mice, but showed a prolonged graft survival when transplanted into diabetic allogenic BALB/c mice. Conclusions/interpretation SOCS3 inhibits IL-1-induced signalling through the nuclear factor-kappa B and MAPK pathways and apoptosis induced by cytokines in primary beta cells. Moreover, Socs3 transgenic islets are protected in an allogenic transplantation model. SOCS3 may represent a target for pharmacological or genetic engineering in islet transplantation for treatment of type 1 diabetes mellitus.
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