| 1. |
- Islam, Md Mafijul, et al.
(författare)
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Towards benchmarking of functional safety in the automotive industry
- 2013
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Ingår i: Lecture Notes in Computr Science. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 1611-3349 .- 0302-9743. - 9783642387883 ; , s. 111-125
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Konferensbidrag (refereegranskat)abstract
- Functional safety is becoming increasingly important in the automotive industry to deal with the growing reliance on the electrical and/or electronic (E/E) systems and the associated complexities. The introduction of ISO 26262, a new standard for functional safety in road vehicles, has made it even more important to adopt a systematic approach of evaluating functional safety. However, standard assessment methods of benchmarking functional safety of automotive systems are not available as of today. This is where the BeSafe (Benchmarking of Functional Safety) project comes into the picture. BeSafe project aims to lay the foundation for benchmarking functional safety of automotive E/E systems. In this paper, we present a brief overview of the project along with the benchmark targets that we have identified as relevant for the automotive industry, assuming three abstraction layers (model, software, hardware). We then define and discuss a set of benchmark measures. Next, we propose a benchmark framework encompassing fault/error models, methods and the required tool support. This paper primarily focuses on functional safety benchmarking from the Safety Element out of Context (SEooC) viewpoint. Finally, we present some preliminary results and highlight potential future works.
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| 2. |
- Ayatolahi, Fatemeh, 1984, et al.
(författare)
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A study of the impact of single bit-flip and double bit-flip errors on program execution
- 2013
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Ingår i: Lect. Notes Comput. Sci.. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 9783642407925 ; , s. 265-276
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Konferensbidrag (refereegranskat)abstract
- This paper presents the results of an extensive experimental study of bit-flip errors in instruction set architecture registers and main memory locations. Comprising more than two million fault injection experiments conducted with thirteen benchmark programs, the study provides insights on whether it is necessary to consider double bit-flip errors in dependability benchmarking experiments. The results show that the proportion of silent data corruptions in the program output, is almost the same for single and double bit errors. In addition, we present detailed statistics about the error sensitivity of different target registers and memory locations, including bit positions within registers and memory words. These show that the error sensitivity varies significantly between different bit positions and registers. An important observation is that injections in certain bit positions always have the same impact regardless of when the error is injected.
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| 3. |
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| 4. |
- Calles, Olle, 1974-, et al.
(författare)
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Success of a low-sloping rack for improving downstream passage of silver eels at a hydroelectric plant
- 2013
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Ingår i: Freshwater Biology. - : John Wiley & Sons. - 0046-5070 .- 1365-2427. ; 58, s. 2168-2179
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Tidskriftsartikel (refereegranskat)abstract
- 1. The European eel (Anguilla anguilla) is a critically endangered species, and one major threat is thesurvival of silver eels migrating downstream towards the sea from lake and river rearing areas. Duringthis migration, many eels are impinged and die on intake racks, or are injured or killed whenpassing through turbines.2. Intake racks at a hydroelectric plant were modified to avoid impingement and to collect eels withoutinjury; high mortality on both racks and in turbines was previously documented. Modificationsconsisted of reducing the rack gap width from 20 to 18 mm, decreasing the rack slope from 63 to 35degrees, increasing the rack surface area by 58% and installing six openings in the rack leading totraps.3. Downstream passage conditions for silver eels at the hydroelectric plant were significantlyimproved, reducing mortality from >70% at the old steep 20 mm racks to <10% at the modified18 mm rack collection facility. No tagged eels were impinged and killed on the racks, and 80%entered the collection facility.4. Survival can probably be improved even more, as the individuals that passed the facility mostlikely escaped through holes in the traps. Moreover, injured untagged eels were still encountered atthe modified racks, illustrating the need for rehabilitative measures to be implemented at all obstaclesbetween the main eel rearing areas and the sea.
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| 5. |
- Cecchinato, Francesca, et al.
(författare)
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In vitro evaluation of human fetal osteoblast response to magnesium loaded mesoporous TiO2 coating.
- 2014
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Ingår i: Journal of Biomedical Materials Research - Part A. - : Wiley. - 1552-4965 .- 1549-3296. ; 102:11, s. 3862-3871
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Tidskriftsartikel (refereegranskat)abstract
- This work aimed to evaluate the in vitro response of Transfected Human Foetal Osteoblast (hFOB) cultured on a magnesium-loaded mesoporous TiO2 coating. The application of mesoporous films on titanium implant surfaces has shown very promising potential to enhance osseointegration. This type of coating has the ability to act as a framework to sustain bioactive agents and different drugs. Magnesium is the element that, after calcium, is the most frequently used to dope titanium implant surfaces, since it is crucial for protein formation, growth factor expression, and aids for bone mineral deposition on implant surfaces. Mesoporous TiO2 films with an average pore-size of 6 nm were produced by the evaporation-induced self-assembly method (EISA) and deposited onto titanium discs. Magnesium loading was performed by soaking the mesoporous TiO2 discs in a magnesium chloride solution. Surface characterization was conducted by SEM, XPS, optical interferometry, and AFM. Magnesium release profile was assessed at different time points using a Magnesium Detection kit. Cell morphology and spreading were observed with SEM. The cytoskeletal organization was stained with TRITC-conjugated Phalloidin and cell viability was evaluated through a mitochondrial colorimetric (MTT) assay. Furthermore, gene expression of bone markers and cell mineralization were analyzed by real time RT-PCR and alizarin-red staining, respectively. The surface chemical analysis by XPS revealed the successful adsorption of magnesium to the mesoporous coating. The AFM measurements revealed the presence of a nanostructured surface roughness. Osteoblasts viability and adhesion as well as the gene expression were unaffected by the addition of magnesium possibly due to its rapid burst release, however, were enhanced by the 3D nanostructure of the TiO2 layer.
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| 6. |
- Di Leo, D., et al.
(författare)
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On the impact of hardware faults - An investigation of the relationship between workload inputs and failure mode distributions
- 2012
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Ingår i: Lect. Notes Comput. Sci.. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 1611-3349 .- 0302-9743. - 9783642336775 ; , s. 198-209
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Konferensbidrag (refereegranskat)abstract
- Technology scaling of integrated circuits is making transistors increasingly sensitive to process variations, wear-out effects and ionizing particles. This may lead to an increasing rate of transient and intermittent errors in future microprocessors. In order to assess the risk such errors pose to safety critical systems, it is essential to investigate how temporary errors in the instruction set architecture (ISA) registers and main memory locations influence the behaviour of executing programs. To this end, we investigate - by means of extensive fault injection experiments - how such errors affect the execution of four target programs. The paper makes three contributions. First, we investigate how the failure modes of the target programs vary for different input sets. Second, we evaluate the error coverage of a software-implemented hardware fault tolerant technique that relies on triple-time redundant execution, majority voting and forward recovery. Third, we propose an approach based on assembly language metrics which can be used to correlate the dynamic fault-free behaviour of a program with its failure mode distribution obtained by fault injection.
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| 7. |
- Galli, Silvia, et al.
(författare)
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Local release of magnesium from mesoporous TiO2 coatings stimulates the peri-implant expression of osteogenic markers and improves osteoconductivity in vivo
- 2014
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Ingår i: Acta Biomaterialia. - : Elsevier. - 1742-7061 .- 1878-7568. ; 10:12, s. 5193-5201
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Tidskriftsartikel (refereegranskat)abstract
- Local release of Mg ions from titanium implant surfaces has been shown to enhance implant retention and integration. To clarify the biological events that lead to this positive outcome, threaded implants coated with mesoporous TiO2 thin films were loaded with Mg-ions and placed in the tibia of rabbits for 3 weeks, after surface characterization. Non-loaded mesoporous coated implants were used as controls. Peri-implant gene expression of a set of osteogenic and inflammatory assays was quantified by means of real-time quantitative polymerase chain reaction. The expression of three osteogenic markers (OC, RUNX-2 and IGF-1) was significantly more pronounced in the test specimens, suggesting that the release of Mg ions directly at the implant sites may stimulate an osteogenic environment. Furthermore, bone healing around implants was evaluated on histological slides and by diffraction-enhanced imaging (DEI), using synchrotron radiation. The histological analysis demonstrated new bone formation around all implants, without negative responses, with a significant increase in the number of threads filled with new bone for test surfaces. DEI analysis attested the high mineral content of the newly formed bone. Improved surface osteoconductivity and increased expression of genes involved in the bone regeneration were found for magnesium-incorporation of mesoporous TiO2 coatings.
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| 8. |
- Gourdon, Mathias, 1980, et al.
(författare)
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Pulp mill biorefineries
- 2013
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Ingår i: International Process Integration Jubilee Conference, Gothenburg, Sweden, March 18-20 2013.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 9. |
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| 10. |
- Harmankaya, Necati, 1983, et al.
(författare)
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Raloxifene and alendronate containing thin mesoporous titanium oxide films improve implant fixation to bone.
- 2013
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Ingår i: Acta biomaterialia. - : Elsevier BV. - 1878-7568 .- 1742-7061. ; 9:6, s. 7064-73
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Tidskriftsartikel (refereegranskat)abstract
- This study tested the hypothesis that osteoporosis drug-loaded mesoporous TiO2 implant coatings can be used to improve bone-implant integration. Two osteoporosis drugs, Alendronate (ALN) and Raloxifene (RLX), were immobilized in nanoporous oxide films prepared on Ti screws and evaluated in vivo in rat tibia. The drug release kinetics were monitored in vitro by quartz crystal microbalance with dissipation and showed sustained release of both drugs. The osteogenic response after 28days of implantation was evaluated by quantitative polymerase chain reaction (qPCR), removal torque, histomorphometry and ultrastructural interface analysis. The drug-loaded implants showed significantly improved bone fixation. In the case of RLX, stronger bone-remodelling activity was observed compared with controls and ALN-loaded implants. The ultrastructural interface analysis revealed enhanced apatite formation inside the RLX coating and increased bone density outside the ALN coating. Thus, this novel combination of a thin mesoporous TiO2 carrier matrix and appropriate drugs can be used to accelerate implant fixation in trabecular bone.
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