| 1. |
- Andersson, Magnus, et al.
(författare)
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Characterization and estimation of turbulence-related wall shear stress in patient-specific pulsatile blood flow
- 2019
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Ingår i: Journal of Biomechanics. - : ELSEVIER SCI LTD. - 0021-9290 .- 1873-2380. ; 85, s. 108-117
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Tidskriftsartikel (refereegranskat)abstract
- Disturbed, turbulent-like blood flow promotes chaotic wall shear stress (WSS) environments, impairing essential endothelial functions and increasing the susceptibility and progression of vascular diseases. These flow characteristics are today frequently detected at various anatomical, lesion and intervention-related sites, while their role as a pathological determinant is less understood. To present-day, numerous WSS-based descriptors have been proposed to characterize the spatiotemporal nature of the WSS disturbances, however, without differentiation between physiological laminar oscillations and turbulence-related WSS (tWSS) fluctuations. Also, much attention has been focused on magnetic resonance (MR) WSS estimations, so far with limited success; promoting the need of a near-wall surrogate marker. In this study, a new approach is explored to characterize the tWSS, by taking advantage of the tensor characteristics of the fluctuating WSS correlations, providing both a magnitude and an anisotropy measure of the disturbances. These parameters were studied in two patient-specific coarctation models (sever and mild), using large eddy simulations, and correlated against near-wall reciprocal Reynolds stress parameters. Collectively, results showed distinct regions of differing tWSS characteristics, features which were sensitive to changes in flow conditions. Generally, the post-stenotic tWSS was governed by near axisymmetric fluctuations, findings that where not consistent with conventional WSS disturbance predictors. At the 2-3 mm wall-offset range, a strong linear correlation was found between tWSS magnitude and near-wall turbulence kinetic energy (TKE), in contrast to the anisotropy indices, suggesting that MR-measured TKE can be used to assess elevated tWSS regions while tWSS anisotropy estimates request well-resolved simulation methods. (C) 2019 Elsevier Ltd. All rights reserved.
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| 2. |
- Andersson, Magnus, et al.
(författare)
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Correction: Quantitative Assessment of Turbulence and Flow Eccentricity in an Aortic Coarctation: Impact of Virtual Interventions (vol 6, pg 281, 2015)
- 2015
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Ingår i: Cardiovascular Engineering and Technology. - : SPRINGER. - 1869-408X .- 1869-4098. ; 6:4, s. 577-589
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Tidskriftsartikel (refereegranskat)abstract
- Turbulence and flow eccentricity can be measured by magnetic resonance imaging (MRI) and may play an important role in the pathogenesis of numerous cardiovascular diseases. In the present study, we propose quantitative techniques to assess turbulent kinetic energy (TKE) and flow eccentricity that could assist in the evaluation and treatment of stenotic severities. These hemodynamic parameters were studied in a pre-treated aortic coarctation (CoA) and after several virtual interventions using computational fluid dynamics (CFD), to demonstrate the effect of different dilatation options on the flow field. Patient-specific geometry and flow conditions were derived from MRI data. The unsteady pulsatile flow was resolved by large eddy simulation (LES) including non-Newtonian blood rheology. Results showed an inverse asymptotic relationship between the total amount of TKE and degree of dilatation of the stenosis, where the pre-stenotic hypoplastic segment may limit the possible improvement by treating the CoA alone. Spatiotem-poral maps of TKE and flow eccentricity could be linked to the characteristics of the post-stenotic jet, showing a versatile response between the CoA dilatations. By including these flow markers into a combined MRI-CFD intervention framework, CoA therapy has not only the possibility to produce predictions via simulation, but can also be validated pre-and immediate post treatment, as well as during follow-up studies.
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| 3. |
- Andersson, Magnus, et al.
(författare)
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Multidirectional WSS disturbances in stenotic turbulent flows: A pre- and post-intervention study in an aortic coarctation
- 2017
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Ingår i: Journal of Biomechanics. - : ELSEVIER SCI LTD. - 0021-9290 .- 1873-2380. ; 51
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Tidskriftsartikel (refereegranskat)abstract
- Wall shear stress (WSS) disturbances are commonly expressed at sites of abnormal flow obstructions and may play an essential role in the pathogenesis of various vascular diseases. In laminar flows these disturbances have recently been assessed by the transverse wall shear stress (transWSS), which accounts for the WSS multidirectionality. Site-specific estimations of WSS disturbances in pulsatile transitional and turbulent type of flows are more challenging due to continuous and unpredictable changes in WSS behavior. In these complex flow settings, the transWSS may serve as a more comprehensive descriptor for assessing WSS disturbances of general nature compared to commonly used parameters. In this study large eddy simulations (LES) were used to investigate the transWSS properties in flows subjected to different pathological turbulent flow conditions, governed by a patient-specific model of an aortic coarctation pre and post balloon angioplasty. Results showed that regions of strong near-wall turbulence were collocated with regions of elevated transWSS and turbulent WSS, while in more transitional-like near-wall flow regions a closer resemblance was found between transWSS and low, and oscillatory WSS. Within the frame of this study, the transWSS parameter demonstrated a more multi-featured picture of WSS disturbances when exposed to different types of flow regimes, characteristics which were not depicted by the other parameters alone. (C) 2016 Published by Elsevier Ltd.
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| 4. |
- Andersson, Magnus, 1983-, et al.
(författare)
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Quantitative Assessment of Turbulence and Flow Eccentricity in an Aortic Coarctation - Impact of Virtual Interventions
- 2015
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Ingår i: Cardiovascular Engineering and Technology. - : Springer. - 1869-408X .- 1869-4098. ; 6:6, s. 281-293
-
Tidskriftsartikel (refereegranskat)abstract
- Turbulence and flow eccentricity can be measured by magnetic resonance imaging (MRI) and may play an important role in the pathogenesis of numerous cardiovascular diseases. In the present study, we propose quantitative techniques to assess turbulent kinetic energy (TKE) and flow eccentricity that could assist in the evaluation and treatment of stenotic severities. These hemodynamic parameters were studied in a pre-treated aortic coarctation (CoA) and after several virtual interventions using computational fluid dynamics (CFD), to demonstrate the effect of different dilatation options on the flow field. Patient-specific geometry and flow conditions were derived from MRI data. The unsteady pulsatile flow was resolved by large eddy simulation (LES) including non-Newtonian blood rheology. Results showed an inverse asymptotic relationship between the total amount of TKE and degree of dilatation of the stenosis, where turbulent flow proximal the constriction limits the possible improvement by treating the CoA alone. Spatiotemporal maps of TKE and flow eccentricity could be linked to the characteristics of the jet, where improved flow conditions were favored by an eccentric dilatation of the CoA. By including these flow markers into a combined MRI-CFD intervention framework, CoA therapy has not only the possibility to produce predictions via simulation, but can also be validated pre- and immediate post treatment, as well as during follow-up studies.
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| 5. |
- Berntsson, Fredrik, 1971-, et al.
(författare)
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A Modification to the Kirchhoff Conditions at a Bifurcation and Loss Coefficients
- 2018
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- One dimensional models for fluid flow in tubes are frequently used tomodel complex systems, such as the arterial tree where a large numberof vessels are linked together at bifurcations. At the junctions transmission conditions are needed. One popular option is the classic Kirchhoffconditions which means conservation of mass at the bifurcation andprescribes a continuous pressure at the joint.In reality the boundary layer phenomena predicts fast local changesto both velocity and pressure inside the bifurcation. Thus it is not appropriate for a one dimensional model to assume a continuous pressure. In this work we present a modification to the classic Kirchhoff condi-tions, with a symmetric pressure drop matrix, that is more suitable forone dimensional flow models. An asymptotic analysis, that has beencarried out previously shows that the new transmission conditions hasen exponentially small error.The modified transmission conditions take the geometry of the bifurcation into account and can treat two outlets differently. The conditions can also be written in a form that is suitable for implementationin a finite difference solver. Also, by appropriate choice of the pressuredrop matrix we show that the new transmission conditions can producehead loss coefficients similar to experimentally obtained ones.
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| 6. |
- Berntsson, Fredrik, 1971-, et al.
(författare)
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A one-dimensional model of a false aneurysm
- 2017
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Ingår i: International Journal of Research in Engineering and Science (IJRES). - : IJRES. - 2320-9356 .- 2320-9364. ; 5:6, s. 61-73
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Tidskriftsartikel (refereegranskat)abstract
- A false aneurysm is a hematoma, i.e. collection ofblood outside of a blood vessel, that forms due to a hole in the wall of an artery . This represents a serious medical condition that needs to be monitored and, under certain conditions, treatedurgently. In this work a one-dimensional model of a false aneurysm isproposed. The new model is based on a one-dimensional model of anartery previously presented by the authors and it takes into accountthe interaction between the hematoma and the surrounding musclematerial. The model equations are derived using rigorous asymptoticanalysis for the case of a simplified geometry. Even though the model is simple it still supports a realisticbehavior for the system consisting of the vessel and the hematoma. Using numerical simulations we illustrate the behavior ofthe model. We also investigate the effect of changing the size of the hematoma. The simulations show that ourmodel can reproduce realistic solutions. For instance we show thetypical strong pulsation of an aneurysm by blood entering the hematoma during the work phase of the cardiac cycle, and the blood returning tothe vessel during the resting phase. Also we show that the aneurysmgrows if the pulse rate is increased due to, e.g., a higher work load.
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| 7. |
- Berntsson, Fredrik, et al.
(författare)
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A one-dimensional model of viscous blood flow in an elastic vessel
- 2016
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Ingår i: Applied Mathematics and Computation. - : ELSEVIER SCIENCE INC. - 0096-3003 .- 1873-5649. ; 274, s. 125-132
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Tidskriftsartikel (refereegranskat)abstract
- In this paper we present a one-dimensional model of blood flow in a vessel segment with an elastic wall consisting of several anisotropic layers. The model involves two variables: the radial displacement of the vessels wall and the pressure, and consists of two coupled equations of parabolic and hyperbolic type. Numerical simulations on a straight segment of a blood vessel demonstrate that the model can produce realistic flow fields that may appear under normal conditions in healthy blood vessels; as well as flow that could appear during abnormal conditions. In particular we show that weakening of the elastic properties of the wall may provoke a reverse blood flow in the vessel. (C) 2015 Elsevier Inc. All rights reserved.
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| 8. |
- Casas Garcia, Belén, et al.
(författare)
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Bridging the gap between measurements and modelling : a cardiovascular functional avatar
- 2017
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Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- Lumped parameter models of the cardiovascular system have the potential to assist researchers and clinicians to better understand cardiovascular function. The value of such models increases when they are subject specific. However, most approaches to personalize lumped parameter models have thus far required invasive measurements or fall short of being subject specific due to a lack of the necessary clinical data. Here, we propose an approach to personalize parameters in a model of the heart and the systemic circulation using exclusively non-invasive measurements. The personalized model is created using flow data from four-dimensional magnetic resonance imaging and cuff pressure measurements in the brachial artery. We term this personalized model the cardiovascular avatar. In our proof-of-concept study, we evaluated the capability of the avatar to reproduce pressures and flows in a group of eight healthy subjects. Both quantitatively and qualitatively, the model-based results agreed well with the pressure and flow measurements obtained in vivo for each subject. This non-invasive and personalized approach can synthesize medical data into clinically relevant indicators of cardiovascular function, and estimate hemodynamic variables that cannot be assessed directly from clinical measurements.
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| 9. |
- Casas Garcia, Belén, et al.
(författare)
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Non-invasive Assessment of Systolic and Diastolic Cardiac Function During Rest and Stress Conditions Using an Integrated Image-Modeling Approach
- 2018
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Ingår i: Frontiers in Physiology. - : FRONTIERS MEDIA SA. - 1664-042X. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- Background: The possibility of non-invasively assessing load-independent parameters characterizing cardiac function is of high clinical value. Typically, these parameters are assessed during resting conditions. However, for diagnostic purposes, the parameter behavior across a physiologically relevant range of heart rate and loads is more relevant than the isolated measurements performed at rest. This study sought to evaluate changes in non-invasive estimations of load-independent parameters of left-ventricular contraction and relaxation patterns at rest and during dobutamine stress. Methods: We applied a previously developed approach that combines non-invasive measurements with a physiologically-based, reduced-order model of the cardiovascular system to provide subject-specific estimates of parameters characterizing left ventricular function. In this model, the contractile state of the heart at each time point along the cardiac cycle is modeled using a time-varying elastance curve. Non-invasive data, including four-dimensional magnetic resonance imaging (4D Flow MRI) measurements, were acquired in nine subjects without a known heart disease at rest and during dobutamine stress. For each of the study subjects, we constructed two personalized models corresponding to the resting and the stress state. Results: Applying the modeling framework, we identified significant increases in the left ventricular contraction rate constant [from 1.5 +/- 0.3 to 2 +/- 0.5 (p = 0.038)] and relaxation constant [from 37.2 +/- 6.9 to 46.1 +/- 12 (p = 0.028)]. In addition, we found a significant decrease in the elastance diastolic time constant from 0.4 +/- 0.04 s to 0.3 +/- 0.03 s = 0.008). Conclusions: The integrated image-modeling approach allows the assessment of cardiovascular function given as model-based parameters. The agreement between the estimated parameter values and previously reported effects of dobutamine demonstrates the potential of the approach to assess advanced metrics of pathophysiology that are otherwise difficult to obtain non-invasively in clinical practice.
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| 10. |
- Ekman, Petter, 1988-, et al.
(författare)
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Accuracy and Speed for Scale-Resolving Simulations of the DrivAer Reference Model
- 2019
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Ingår i: WCX SAE World Congress Experience. - 400 Commonwealth Drive, Warrendale, PA, United States : SAE International.
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Konferensbidrag (refereegranskat)abstract
- In aerodynamic development of ground vehicles, the use of Computational Fluid Dynamics (CFD) is crucial for improving the aerodynamic performance, stability and comfort of the vehicle. Simulation time and accuracy are two key factors of a well working CFD procedure. Using scale-resolving simulations, accurate predictions of the flow field and aerodynamic forces are possible, but often leads to long simulation time. For a given solver, one of the most significant aspects of the simulation time/cost is the temporal resolution. In this study, this aspect is investigated using the realistic vehicle model DrivAer with the notchback geometry as the test case. To ensure a direct and accurate comparison with wind tunnel measurements, performed at TU Berlin, a large section of the wind tunnel is included in the simulation domain. All simulations are performed at a Reynolds number of 3.12 million, based on the vehicle length. Three spatial resolutions were compared, where it could be seen that a hybrid element mesh consisting of 102 million cells only revealed small differences to the finest mesh investigated, well as showing excellent agreement with wind tunnel measurements. An investigation of the temporal resolution is performed, in order to see its effect on the simulation time/cost and accuracy of the results. The finest temporal resolution resulted in a Courant-Friedrichs-Lewy number less than unity, while the coarsest reached a CFL number of around 100. From these results, it is seen that it is possible to reduce the simulation time with more than 90 % (CFL 20) and still keep sufficient accuracy of the forces and important features of the flow field.
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