Sökning: WFRF:(Kasereka M)
> (2020-2021) >
Bacteria and viruse...
Bacteria and viruses in the upper respiratory tract of Congolese children with radiologically confirmed pneumonia
-
- Birindwa, Archippe M. (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
-
Kasereka, J. K. (författare)
-
- Gonzales-Siles, Lucia (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
-
visa fler...
-
- Geravandi, Shadi (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
-
Mwilo, M. (författare)
-
Tudiakwile, L. K. (författare)
-
Mwinja, N. L. (författare)
-
Muhigirwa, B. (författare)
-
Kashosi, T. (författare)
-
Manegabe, J. T. (författare)
-
Bugashane, E. B. (författare)
-
Saili, S. M. (författare)
-
Mungo, C. (författare)
-
- Nordén, Rickard, 1977 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
-
- Andersson, Rune, 1951 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
-
- Skovbjerg, Susann, 1973 (författare)
- Gothenburg University,Göteborgs universitet,CARe - Centrum för antibiotikaresistensforskning,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Centre for antibiotic resistance research, CARe,Institute of Biomedicine, Department of Infectious Medicine
-
visa färre...
-
(creator_code:org_t)
- 2021-08-19
- 2021
- Engelska.
-
Ingår i: Bmc Infectious Diseases. - : Springer Science and Business Media LLC. - 1471-2334. ; 21:1
- Relaterad länk:
-
https://bmcinfectdis...
-
visa fler...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background Acute pneumonia remains a leading cause of death among children below 5 years of age in the Democratic Republic of the Congo (DR Congo), despite introduction of the 13-valent pneumococcal conjugate vaccine (PCV13) in 2013. Potential pathogens in the nasopharynx of hospitalised children with pneumonia have not been studied previously in DR Congo. Here we compare clinical characteristics, risk factors and nasopharyngeal occurrence of bacteria and viruses between children with severe and non-severe pneumonia. Methods Between June 2015 and June 2017, 116 children aged from 2 to 59 months hospitalised due to radiologically confirmed pneumonia at Panzi referral university hospital, Bukavu, Eastern DR Congo were included in the study and sampled from nasopharynx. A multiplex real-time PCR assay for detection of 15 different viruses and 5 bacterial species was performed and another multiplex PCR assay was used for pneumococcal serotype/serogroup determination. Results During the study period 85 (73%) of the children with radiologically confirmed pneumonia met the WHO classification criteria of severe pneumonia and 31 (27%) had non-severe pneumonia. The fatality rate was 9.5%. Almost all (87%) children were treated with antibiotics before they were hospitalised, in most cases with amoxicillin (58%) or trimethoprim-sulfamethoxazole (20%). The frequency of potential pathogens in the nasopharynx of the children was high, and any viral or bacterial nucleic acids present at high levels, irrespective of species or type, were significantly associated with severe pneumonia as compared with non-severe cases (52% versus 29%, p = 0.032). White blood cell count > 20,000/mu L and C-Reactive Protein > 75 mg/dL were associated with severe pneumonia at admission. Fatal outcome was in the multivariable analysis associated with having a congenital disease as an underlying condition. One or more pneumococcal serotypes/serogroups could be identified in 61 patients, and out of all identified serotypes 31/83 (37%) were non-PCV13 serotypes. Conclusions The occurrence of any bacteria or any viruses at high levels was associated with severe pneumonia at admission. Children with congenital disorders might need a higher attention when having symptoms of acute respiratory infection, as developed pneumonia could lead to fatal outcome.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Bacteria
- Viruses
- Nasopharynx
- Radiologically confirmed pneumonia
- Hospitalised children
- Pneumococcal serotypes
- serogroups
- Democratic
- Republic of the Congo
- streptococcus-pneumoniae
- haemophilus-influenzae
- antimicrobial
- activity
- young-children
- antibiotic use
- infections
- density
- burden
- urine
- era
- Infectious Diseases
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Birindwa, Archip ...
-
Kasereka, J. K.
-
Gonzales-Siles, ...
-
Geravandi, Shadi
-
Mwilo, M.
-
Tudiakwile, L. K ...
-
visa fler...
-
Mwinja, N. L.
-
Muhigirwa, B.
-
Kashosi, T.
-
Manegabe, J. T.
-
Bugashane, E. B.
-
Saili, S. M.
-
Mungo, C.
-
Nordén, Rickard, ...
-
Andersson, Rune, ...
-
Skovbjerg, Susan ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Infektionsmedici ...
- Artiklar i publikationen
-
Bmc Infectious D ...
- Av lärosätet
-
Göteborgs universitet