| 1. |
- Tierney, W., et al.
(författare)
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A creative destruction approach to replication : Implicit work and sex morality across cultures
- 2021
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Ingår i: Journal of Experimental Social Psychology. - : Elsevier BV. - 0022-1031 .- 1096-0465. ; 93
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Tidskriftsartikel (refereegranskat)abstract
- How can we maximize what is learned from a replication study? In the creative destruction approach to replication, the original hypothesis is compared not only to the null hypothesis, but also to predictions derived from multiple alternative theoretical accounts of the phenomenon. To this end, new populations and measures are included in the design in addition to the original ones, to help determine which theory best accounts for the results across multiple key outcomes and contexts. The present pre-registered empirical project compared the Implicit Puritanism account of intuitive work and sex morality to theories positing regional, religious, and social class differences; explicit rather than implicit cultural differences in values; self-expression vs. survival values as a key cultural fault line; the general moralization of work; and false positive effects. Contradicting Implicit Puritanism's core theoretical claim of a distinct American work morality, a number of targeted findings replicated across multiple comparison cultures, whereas several failed to replicate in all samples and were identified as likely false positives. No support emerged for theories predicting regional variability and specific individual-differences moderators (religious affiliation, religiosity, and education level). Overall, the results provide evidence that work is intuitively moralized across cultures.
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| 2. |
- De Leoz, M. L. A., et al.
(författare)
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NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods
- 2020
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Ingår i: Molecular & Cellular Proteomics. - 1535-9476. ; 19:1, s. 11-30
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Tidskriftsartikel (refereegranskat)abstract
- A broad-based interlaboratory study of glycosylation profiles of a reference and modified IgG antibody involving 103 reports from 76 laboratories. Glycosylation is a topic of intense current interest in the development of biopharmaceuticals because it is related to drug safety and efficacy. This work describes results of an interlaboratory study on the glycosylation of the Primary Sample (PS) of NISTmAb, a monoclonal antibody reference material. Seventy-six laboratories from industry, university, research, government, and hospital sectors in Europe, North America, Asia, and Australia submitted a total of 103 reports on glycan distributions. The principal objective of this study was to report and compare results for the full range of analytical methods presently used in the glycosylation analysis of mAbs. Therefore, participation was unrestricted, with laboratories choosing their own measurement techniques. Protein glycosylation was determined in various ways, including at the level of intact mAb, protein fragments, glycopeptides, or released glycans, using a wide variety of methods for derivatization, separation, identification, and quantification. Consequently, the diversity of results was enormous, with the number of glycan compositions identified by each laboratory ranging from 4 to 48. In total, one hundred sixteen glycan compositions were reported, of which 57 compositions could be assigned consensus abundance values. These consensus medians provide community-derived values for NISTmAb PS. Agreement with the consensus medians did not depend on the specific method or laboratory type. The study provides a view of the current state-of-the-art for biologic glycosylation measurement and suggests a clear need for harmonization of glycosylation analysis methods.
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| 3. |
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| 5. |
- Bonavita, M., et al.
(författare)
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New binaries from the SHINE survey
- 2022
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 663
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Tidskriftsartikel (refereegranskat)abstract
- We present the multiple stellar systems observed within the SpHere INfrared survey for Exoplanet (SHINE). SHINE searched for sub-stellar companions to young stars using high contrast imaging. Although stars with known stellar companions within the SPHERE field of view (< 5.5 arcsec) were removed from the original target list, we detected additional stellar companions to 78 of the 463 SHINE targets observed so far. Twenty-seven per cent of the systems have three or more components. Given the heterogeneity of the sample in terms of observing conditions and strategy, tailored routines were used for data reduction and analysis, some of which were specifically designed for these datasets. We then combined SPHERE data with literature and archival data, TESS light curves, and Gaia parallaxes and proper motions for an accurate characterisation of the systems. Combining all data, we were able to constrain the orbits of 25 systems. We carefully assessed the completeness of our sample for separations between 50–500 mas (corresponding to periods of a few years to a few decades), taking into account the initial selection biases and recovering part of the systems excluded from the original list due to their multiplicity. This allowed us to compare the binary frequency for our sample with previous studies and highlight interesting trends in the mass ratio and period distribution. We also found that, when such an estimate was possible, the values of the masses derived from dynamical arguments were in good agreement with the model predictions. Stellar and orbital spins appear fairly well aligned for the 12 stars that have enough data, which favours a disk fragmentation origin. Our results highlight the importance of combining different techniques when tackling complex problems such as the formation of binaries and show how large samples can be useful for more than one purpose.
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| 6. |
- Stacchiotti, S., et al.
(författare)
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Epithelioid hemangioendothelioma, an ultra-rare cancer : a consensus paper from the community of experts
- 2021
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Ingår i: ESMO Open. - : Elsevier BV. - 2059-7029. ; 6:3
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Forskningsöversikt (refereegranskat)abstract
- Epithelioid hemangioendothelioma (EHE) is an ultra-rare, translocated, vascular sarcoma. EHE clinical behavior is variable, ranging from that of a low-grade malignancy to that of a high-grade sarcoma and it is marked by a high propensity for systemic involvement. No active systemic agents are currently approved specifically for EHE, which is typically refractory to the antitumor drugs used in sarcomas. The degree of uncertainty in selecting the most appropriate therapy for EHE patients and the lack of guidelines on the clinical management of the disease make the adoption of new treatments inconsistent across the world, resulting in suboptimal outcomes for many EHE patients. To address the shortcoming, a global consensus meeting was organized in December 2020 under the umbrella of the European Society for Medical Oncology (ESMO) involving >80 experts from several disciplines from Europe, North America and Asia, together with a patient representative from the EHE Group, a global, disease-specific patient advocacy group, and Sarcoma Patient EuroNet (SPAEN). The meeting was aimed at defining, by consensus, evidence-based best practices for the optimal approach to primary and metastatic EHE. The consensus achieved during that meeting is the subject of the present publication.
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| 7. |
- Gratton, R., et al.
(författare)
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Investigating three Sirius-like systems with SPHERE
- 2021
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 646
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Tidskriftsartikel (refereegranskat)abstract
- Context. Sirius-like systems are relatively wide binaries with a separation from a few to hundreds of au; they are composed of a white dwarf (WD) and a companion of a spectral type earlier than M0. Here we consider main sequence (MS) companions, where the WD progenitor evolves in isolation, but its wind during the former asymptotic giant branch (AGB) phase pollutes the companion surface and transfers some angular momentum. They are rich laboratories to constrain stellar models and binary evolution.Aims. Within the SpHere INfrared survey for Exoplanet survey that uses the Spectro-Polarimetric High-contrast Exoplanet REsearch (SPHERE) instrument at the Very Large Telescope, our goal is to acquire high contrast multi-epoch observations of three Sirius-like systems, HD 2133, HD 114174, and CD-56 7708 and to combine this data with archive high resolution spectra of the primaries, TESS archive, and literature data.Methods. These WDs are easy targets for SPHERE and were used as spectrophotometric standards. We performed very accurate abundance analyses for the MS stars using methods considered for solar analogs. Whenever possible, WD parameters and orbits were obtained using Monte Carlo Markov chain methods.Results. We found brighter J and K magnitudes for HD 114174B than obtained previously and extended the photometry down to 0.95 μm. Our new data indicate a higher temperature and then shorter cooling age (5.57 ± 0.02 Gyr) and larger mass (0.75 ± 0.03 M⊙) for this WD than previously assumed. Together with the oldest age for the MS star connected to the use of the Gaia DR2 distance, this solved the discrepancy previously found with the age of the MS star. The two other WDs are less massive, indicating progenitors of ∼1.3 M⊙ and 1.5 − 1.8 M⊙ for HD 2133B and CD-56 7708B, respectively. In spite of the rather long periods, we were able to derive useful constraints on the orbit for HD 114174 and CD-56 7708. They are both seen close to edge-on, which is in agreement with the inclination of the MS stars that are obtained coupling the rotational periods, stellar radii, and the projected rotational velocity from spectroscopy. The composition of the MS stars agrees fairly well with expectations from pollution by the AGB progenitors of the WDs: HD 2133A has a small enrichment of n-capture elements, which is as expected for pollution by an AGB star with an initial mass < 1.5 M⊙; CD-56 7708A is a previously unrecognized mild Ba-star, which is also expected due to pollution by an AGB star with an initial mass in the range of 1.5 − 3.0 M⊙; and HD 114174 has a very moderate excess of n-capture elements, which is in agreement with the expectation for a massive AGB star to have an initial mass > 3.0 M⊙.Conclusions. On the other hand, none of these stars show the excesses of C that are expected to go along with those of n-capture elements. This might be related to the fact that these stars are at the edges of the mass range where we expect nucleosynthesis related to thermal pulses. More work, both theoretical and observational, is required to better understand this issue.
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| 8. |
- Bonfanti, A., et al.
(författare)
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Characterising TOI-732 b and c: New insights into the M-dwarf radius and density valley ★,★★
- 2024
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Ingår i: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 682
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Tidskriftsartikel (refereegranskat)abstract
- TOI-732 is an M dwarf hosting two transiting planets that are located on the two opposite sides of the radius valley. Inferring a reliable demographics for this type of systems is key to understanding their formation and evolution mechanisms. Aims. By doubling the number of available space-based observations and increasing the number of radial velocity (RV) measurements, we aim at refining the parameters of TOI-732 b and c. We also use the results to study the slope of the radius valley and the density valley for a well-characterised sample of M-dwarf exoplanets. Methods. We performed a global Markov chain Monte Carlo analysis by jointly modelling ground-based light curves and CHEOPS and TESS observations, along with RV time series both taken from the literature and obtained with the MAROON-X spectrograph. The slopes of the M-dwarf valleys were quantified via a support vector machine (SVM) procedure. Results. TOI-732 b is an ultrashort-period planet (P = 0.76837931−+000000004200000039 days) with a radius Rb = 1.325+−00057058 R☉, a mass Mb = 2.46 ± 0.19 M☉, and thus a mean density ρb = 5.8+−1008 g cm−3, while the outer planet at P = 12.252284 ± 0.000013 days has Rc = 2.39+−001011 R☉, Mc = 8.04+−005048 M☉, and thus ρc = 3.24+−005543 g cm−3. Even with respect to the most recently reported values, this work yields uncertainties on the transit depths and on the RV semi-amplitudes that are smaller up to a factor of ∼1.6 and ∼2.4 for TOI-732 b and c, respectively. Our calculations for the interior structure and the location of the planets in the mass-radius diagram lead us to classify TOI-732 b as a super-Earth and TOI-732 c as a mini-Neptune. Following the SVM approach, we quantified d log Rp,valley/d log P = −0.065+−00024013, which is flatter than for Sun-like stars. In line with former analyses, we note that the radius valley for M-dwarf planets is more densely populated, and we further quantify the slope of the density valley as d log ρ̂valley/d log P = −0.02+−001204. Conclusions. Compared to FGK stars, the weaker dependence of the position of the radius valley on the orbital period might indicate that the formation shapes the radius valley around M dwarfs more strongly than the evolution mechanisms.
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| 9. |
- Chaturvedi, P., et al.
(författare)
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TOI-1468: A system of two transiting planets, a super-Earth and a mini-Neptune, on opposite sides of the radius valley
- 2022
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 666
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Tidskriftsartikel (refereegranskat)abstract
- We report the discovery and characterization of two small transiting planets orbiting the bright M3.0V star TOI-1468 (LSPM J0106+1913), whose transit signals were detected in the photometric time series in three sectors of the TESS mission. We confirm the planetary nature of both of them using precise radial velocity measurements from the CARMENES and MAROON-X spectrographs, and supplement them with ground-based transit photometry. A joint analysis of all these data reveals that the shorter-period planet, TOI-1468 b (P-b = 1.88 d), has a planetary mass of M-b = 3.21 +/- 0.24M(circle plus) and a radius of R-b = 1.280(-0.039)(+0.038) R-circle plus, resulting in a density of rho(b) = 8.39(-0.92)(+1.05) g cm(-3), which is consistent with a mostly rocky composition. For the outer planet, TOI-1468 c (P-c = 15.53 d), we derive a mass of M-c = 6.64(-0.68)(+0.67) M-circle plus,aradius of R-c = 2.06 +/- 0.04 R-circle plus, and a bulk density of rho(c) = 2.00(-0.19)(+0.21) g cm(-3), which corresponds to a rocky core composition with a H/He gas envelope. These planets are located on opposite sides of the radius valley, making our system an interesting discovery as there are only a handful of other systems with the same properties. This discovery can further help determine a more precise location of the radius valley for small planets around M dwarfs and, therefore, shed more light on planet formation and evolution scenarios.
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| 10. |
- Desidera, S., et al.
(författare)
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The SPHERE infrared survey for exoplanets (SHINE) I. Sample definition and target characterization
- 2021
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 651
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Tidskriftsartikel (refereegranskat)abstract
- Context. Large surveys with new-generation high-contrast imaging instruments are needed to derive the frequency and properties of exoplanet populations with separations from ~5 to 300 au. A careful assessment of the stellar properties is crucial for a proper understanding of when, where, and how frequently planets form, and how they evolve. The sensitivity of detection limits to stellar age makes this a key parameter for direct imaging surveys.Aims. We describe the SpHere INfrared survey for Exoplanets (SHINE), the largest direct imaging planet-search campaign initiated at the VLT in 2015 in the context of the SPHERE Guaranteed Time Observations of the SPHERE consortium. In this first paper we present the selection and the properties of the complete sample of stars surveyed with SHINE, focusing on the targets observed during the first phase of the survey (from February 2015 to February 2017). This early sample composed of 150 stars is used to perform a preliminary statistical analysis of the SHINE data, deferred to two companion papers presenting the survey performance, main discoveries, and the preliminary statistical constraints set by SHINE.Methods. Based on a large database collecting the stellar properties of all young nearby stars in the solar vicinity (including kinematics, membership to moving groups, isochrones, lithium abundance, rotation, and activity), we selected the original sample of 800 stars that were ranked in order of priority according to their sensitivity for planet detection in direct imaging with SPHERE. The properties of the stars that are part of the early statistical sample wererevisited, including for instance measurements from the Gaia Data Release 2. Rotation periods were derived for the vast majority of the late-type objects exploiting TESS light curves and dedicated photometric observations.Results. The properties of individual targets and of the sample as a whole are presented.
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