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- Chalmers, J. R., et al.
(författare)
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Report from the third international consensus meeting to harmonise core outcome measures for atopic eczema/dermatitis clinical trials (HOME)
- 2014
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Ingår i: British Journal of Dermatology. - : Oxford University Press (OUP). - 1365-2133 .- 0007-0963. ; 171:6, s. 1318-1325
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Tidskriftsartikel (refereegranskat)abstract
- This report provides a summary of the third meeting of the Harmonising Outcome Measures for Eczema (HOME) initiative held in San Diego, CA, U.S.A., 6-7 April 2013 (HOME III). The meeting addressed the four domains that had previously been agreed should be measured in every eczema clinical trial: clinical signs, patient-reported symptoms, long-term control and quality of life. Formal presentations and nominal group techniques were used at this working meeting, attended by 56 voting participants (31 of whom were dermatologists). Significant progress was made on the domain of clinical signs. Without reference to any named scales, it was agreed that the intensity and extent of erythema, excoriation, oedema/papulation and lichenification should be included in the core outcome measure for the scale to have content validity. The group then discussed a systematic review of all scales measuring the clinical signs of eczema and their measurement properties, followed by a consensus vote on which scale to recommend for inclusion in the core outcome set. Research into the remaining three domains was presented, followed by discussions. The symptoms group and quality of life groups need to systematically identify all available tools and rate the quality of the tools. A definition of long-term control is needed before progress can be made towards recommending a core outcome measure.
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| 2. |
- Miyoshi, Y., et al.
(författare)
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The energization and radiation in geospace (ERG) project
- 2012
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Ingår i: Dynamics of The Earth's Radiation Belts and Inner Magnetosphere. - : American Geophysical Union (AGU). - 9780875904894 ; , s. 103-116
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Konferensbidrag (refereegranskat)abstract
- The Energization and Radiation in Geospace (ERG) project for solar cycle 24 will explore how relativistic electrons in the radiation belts are generated during space storms. This geospace exploration project consists of three research teams: the ERG satellite observation team, the ground-based network observation team, and the integrated data analysis/simulation team. Satellite observation will provide in situ measurements of features such as the plasma distribution function, electric and magnetic fields, and plasma waves, whereas remote sensing by ground-based observations using, for example, HF radars, magnetometers, optical instruments, and radio wave receivers will provide the global state of the geospace. Various kinds of data will be integrated and compared with numerical simulations for quantitative understanding. Such a synergetic approach is essential for comprehensive understanding of relativistic electron generation/loss processes through crossenergy and cross-regional coupling in which different plasma populations and regions are dynamically coupled with each other. In addition, the ERG satellite will utilize a new and innovative measurement technique for wave-particle interactions that can directly measure the energy exchange process between particles and plasma waves. In this paper, we briefly review some of the profound problems regarding relativistic electron accelerations and losses that will be solved by the ERG project, and we provide an overview of the project.
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| 5. |
- Kurita, S., et al.
(författare)
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THEMIS observation of chorus elements without a gap at half the gyrofrequency
- 2012
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 117, s. A11223-
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Tidskriftsartikel (refereegranskat)abstract
- Using waveform data obtained by one of the THEMIS satellites, we report properties of rising tone chorus elements without a gap at half the gyrofrequency in a region close to the magnetic equator. The wave normal angle of the chorus elements is typically field-aligned in the entire frequency range of both upper-band and lower-band chorus emissions. We find that the observed frequency sweep rates are consistent with the estimation based on the nonlinear wave growth theory of Omura et al. (2008). In addition, we compare the frequency profiles of the chorus wave amplitudes with those of the optimum and threshold wave amplitudes derived from the nonlinear wave growth theory for triggering rising tone chorus emissions. The results of the comparison show a reasonable agreement, indicating that rising tone chorus elements are continually generated through a triggering process which generates elements with the optimum amplitudes for nonlinear growth.
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