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Träfflista för sökning "WFRF:(Kemp S.) srt2:(2005-2009)"

Sökning: WFRF:(Kemp S.) > (2005-2009)

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  • Gilbert, M. Thomas P., et al. (författare)
  • Whole-genome shotgun sequencing of mitochondria from ancient hair shafts
  • 2007
  • Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 317:5846, s. 1927-1930
  • Tidskriftsartikel (refereegranskat)abstract
    • Although the application of sequencing-by-synthesis techniques to DNA extracted from bones has revolutionized the study of ancient DNA, it has been plagued by large fractions of contaminating environmental DNA. The genetic analyses of hair shafts could be a solution: We present 10 previously unexamined Siberian mammoth (Mammuthus primigenius) mitochondrial genomes, sequenced with up to 48-fold coverage. The observed levels of damage-derived sequencing errors were lower than those observed in previously published frozen bone samples, even though one of the specimens was >50,000 14C years old and another had been stored for 200 years at room temperature. The method therefore sets the stage for molecular-genetic analysis of museum collections.
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  • Wigforss, Eva, et al. (författare)
  • Experiencing the University Context
  • 2006
  • Ingår i: Proceedings of the Fifth International Conference on Networked Learning 2006. - 186220182X
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • Our problem is how to design, with the use of distance and ICT, an appropriate academic context for learning, for students with no previous knowledge of this context. Our aim is to analyse and describe the learner’s relation to the object of his/her studies as part of his/her relation to the learning activity. By using a combination of a phenomenographic approach and activity system theory, we analyse how students experience the learning environment in the extended university. Our results are based in the learner’s perspective. A new methodological approach, using the techniques of creating an intersubjective field, is discussed at the end of the paper.
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  • Gilbert, M. Thomas P., et al. (författare)
  • Intraspecific phylogenetic analysis of Siberian woolly mammoths using complete mitochondrial genomes
  • 2008
  • Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 105:24, s. 8327-8332
  • Tidskriftsartikel (refereegranskat)abstract
    • We report five new complete mitochondrial DNA (mtDNA) genomes of Siberian woolly mammoth (Mammuthus primigenius), sequenced with up to 73-fold coverage from DNA extracted from hair shaft material. Three of the sequences present the first complete mtDNA genomes of mammoth clade II. Analysis of these and 13 recently published mtDNA genomes demonstrates the existence of two apparently sympatric mtDNA clades that exhibit high interclade divergence. The analytical power afforded by the analysis of the complete mtDNA genomes reveals a surprisingly ancient coalescence age of the two clades, approximate to 1-2 million years, depending on the calibration technique. Furthermore, statistical analysis of the temporal distribution of the C-14 ages of these and previously identified members of the two mammoth clades suggests that clade II went extinct before clade I. Modeling of protein structures failed to indicate any important functional difference between genomes belonging to the two clades, suggesting that the loss of clade II more likely is due to genetic drift than a selective sweep.
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