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Sökning: WFRF:(Kerr Rachel) > (2023)

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1.
  • Fernandez-Rozadilla, Ceres, et al. (författare)
  • Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries
  • 2023
  • Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 55, s. 89-99
  • Tidskriftsartikel (refereegranskat)abstract
    • Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of European and east Asian ancestry, identifying 205 independent risk associations, of which 50 were unreported. We performed integrative genomic, transcriptomic and methylomic analyses across large bowel mucosa and other tissues. Transcriptome- and methylome-wide association studies revealed an additional 53 risk associations. We identified 155 high-confidence effector genes functionally linked to CRC risk, many of which had no previously established role in CRC. These have multiple different functions and specifically indicate that variation in normal colorectal homeostasis, proliferation, cell adhesion, migration, immunity and microbial interactions determines CRC risk. Crosstissue analyses indicated that over a third of effector genes most probably act outside the colonic mucosa. Our findings provide insights into colorectal oncogenesis and highlight potential targets across tissues for new CRC treatment and chemoprevention strategies.
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2.
  • Mirzabaev, Alisher, et al. (författare)
  • Climate Change and Food Systems
  • 2023
  • Ingår i: Science and Innovations for Food Systems Transformation. - Cham : Springer International Publishing. - 9783031157028 - 9783031157035 ; , s. 511-529
  • Bokkapitel (refereegranskat)abstract
    • Climate change affects the functioning of all of the components of food systems, often in ways that exacerbate existing predicaments and inequalities among regions of the world and groups in society. At the same time, food systems are a major cause of climate change, accounting for a third of all greenhouse gas (GHG) emissions. Therefore, food systems can and should play a much bigger role in climate policies. This chapter highlights nine action points for climate change adaptation and mitigation in food systems. The chapter shows that numerous practices, technologies, knowledge and social capital already exist for climate action in food systems, with multiple synergies with other important goals, such as the conservation of biodiversity, the safeguarding of ecosystem services, sustainable land management and reducing social and gender inequalities. Many of these solutions are presently being applied at local scales around the world, even if not at sufficient levels. Hence, the major effort to unleash their potential would involve overcoming various technical, political-economic and structural barriers for their much wider application. Some other solutions require research and development investments now, but will focus on helping us meet the longer-term challenges of climate change in regard to food systems in the second half of this century, when most existing food production practices will face unprecedented challenges. In the short term, these pro-poor policy changes and support systems can have a range of positive effects well beyond food systems without delay. In the long term, investments in research will help ensure food security and ecosystem integrity for coming generations.
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