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- Bergström, Mats, et al.
(författare)
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PET with [11C]-Metomidate for the Visualization of Adrenocortical Tumors and Discrimination from Other Lesions
- 1999
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Ingår i: Clinical Positron Imaging. - 1095-0397 .- 1878-5751. ; 2:6, s. 339-
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Tidskriftsartikel (refereegranskat)abstract
- Purpose:The purpose of the study was to evaluate the potential role of PET with the adrenocortical-specific tracer 11C-metomidate in the characterization of incidentally found adrenal cortical lesions and in adrenocortical carcinomas.Methods:PET with 11C-metomidate was performed in 15 patients with unilateral adrenal mass confirmed by CT (incidentalomas) and in 9 additional patients with adrenocortical cancer. All incidentalomas subsequently underwent surgery, except 2 subjected to biopsy only. These lesions were histopathologically examined and diagnosed as adrenal cortical adenoma (n = 6; 3 nonfunctioning), adrenocortical carcinoma (n = 2) and nodular hyperplasia (n = 1). The remaining were non-cortical lesions including 1 pheochromocytoma, 1 myelolipoma, 2 adrenal cysts, and 2 metastases.Results:All lesions, except 1, with an adrenocortical origin were easily identified due to exceedingly high uptake of 11C-metomidate, whereas the non-cortical lesions showed very low uptake. The 1 false negative was a cancer that at surgery was found to be extensively necrotic. High uptake was also seen in normal adrenal glands. The tracer uptake kinetics indicated trapping of the tracer in the cortical lesions. For quantitative evaluation of tracer binding in individual lesions, the simple SUV concept was found to be equally accurate as more elaborate kinetic analyses.Conclusion:The patients presented and altogether over 40 PET investigations have demonstrated 11C-metomidate to be an attractive tracer for the characterization of adrenal masses with the ability to discriminate lesions of adrenal cortical origin from non-cortical lesions. Additionally the method allows the assessment of metastases from adrenocortical cancers, and the very high contrast has allowed partial whole-body examinations.
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- Edlund, Håkan, 1966-, et al.
(författare)
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Formation of a Liquid Crystalline Phase in the Sodium Taurodeoxycholate-Water System
- 1998
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Ingår i: Langmuir. - Washington DC : ACS Publications. - 0743-7463 .- 1520-5827. ; 14, s. 3691-3697
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Tidskriftsartikel (refereegranskat)abstract
- The binary phase equilibria for the system sodium taurodeoxycholate-water have been studied. The system forms a liquid crystalline phase in addition to the previously known isotropic solution phase at 22 °C. 2H (water) NMR quadrupole splitting, SAXS data in combination with the polarizing microscopic texture observed for the liquid crystal indicate that the liquid crystalline phase consists of a hexagonal-type aggregate structure. A metastable liquid crystal, probably with lamellar-type structure, also appears to exist prior to the formation of the stable hexagonal phase. A micellar growth is measured with the NMR self-diffusion method for the isotropic solution phase. Electrical conductance experiments are used to determine the liquid crystal-solution thermal transition.
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