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- Bousquet, J, et al.
(författare)
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Severe chronic allergic (and related) diseases: a uniform approach--a MeDALL--GA2LEN--ARIA position paper
- 2012
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Ingår i: International archives of allergy and immunology. - : S. Karger AG. - 1423-0097 .- 1018-2438. ; 158:3, s. 216-231
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Tidskriftsartikel (refereegranskat)abstract
- Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as comorbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies.
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| 3. |
- Khayat, Philippe G, et al.
(författare)
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Clinical Outcome of Dental Implants Placed with High Insertion Torques (Up to 176Ncm).
- 2013
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Ingår i: Clinical implant dentistry and related research. - : Wiley. - 1708-8208 .- 1523-0899.
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Tidskriftsartikel (refereegranskat)abstract
- Background: Primary stability can be improved by using a tapered implant in a slightly underprepared implant site. This may lead to high compression forces and elevated insertion torques. It has been postulated that disturbance of the local microcirculation may occur, leading to necrosis of the osteocytes and bone resorption. Purpose: Report on the clinical outcome of 42 implants placed with an insertion torque equal or greater than 70Ncm and evaluate bone levels around these implants. Materials and Methods: This prospective study included 48 patients treated with 66 4.5mm diameter Tapered Screw-Vent implants (Zimmer Dental®, Carlsbad, CA, USA). Maximum insertion torque (MIT) was recorded with an electronic torque measuring device (Tohnichi® STC200CN, Hitachi, Tokyo, Japan). Nine implants (control group) presented MIT between 30 and 50Ncm (mean=37.1Ncm) and 42 implants (experimental group) MIT greater than 70Ncm (mean=110.6Ncm, range: 70.8-176Ncm). Marginal bone levels were recorded at the time of loading and 1 year later for the two groups. Results: After 2-3 months of non-sumerged healing, all implants were clinically stable. Mean marginal bone resorption was 1.03mm (SD=0.44) for the control group (low torque) and 0.72mm (SD=0.56) for the experimental group (high torque) at time of loading, and 1.09 (SD=0.62) and 1.24mm (SD=0.75), respectively, after 1 year. There were no significant differences between the two groups for bone stability and implant success rate. Conclusions: The use of high insertion torques (up to 176Ncm) did not prevent osseointegration. Marginal bone levels in the control and experimental groups were similar both at the time of loading and 1 year later.
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