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- Fernandez, J. L. Abelleira, et al.
(författare)
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A Large Hadron Electron Collider at CERN
- 2012
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Ingår i: Journal of Physics G. - : IOP Publishing. - 0954-3899 .- 1361-6471. ; 39:7
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Tidskriftsartikel (refereegranskat)
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| 7. |
- Gnad, T., et al.
(författare)
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Adenosine activates brown adipose tissue and recruits beige adipocytes via A(2A) receptors
- 2014
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 516:7531
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Tidskriftsartikel (refereegranskat)abstract
- Brown adipose tissue (BAT) is specialized in energy expenditure, making it a potential target for anti-obesity therapies(1-5). Following exposure to cold, BAT is activated by the sympathetic nervous system with concomitant release of catecholamines and activation of beta-adrenergic receptors(1-5). Because BAT therapies based on cold exposureor beta-adrenergic agonists are clinically not feasible, alternative strategies must be explored. Purinergic co-transmission might be involved in sympathetic control of BAT and previous studies reported inhibitory effects of the purinergic transmitter adenosine in BAT from hamster or rat(6-8). However, the role of adenosine in human BAT is unknown. Here we show that adenosine activates human and murine brown adipocytes at low nanomolar concentrations. Adenosine is released in BAT during stimulation of sympathetic nerves as well as from brown adipocytes. The adenosine A(2A) receptor is the most abundant adenosine receptor in human and murine BAT. Pharmacological blockade or genetic loss of A(2A) receptors in mice causes adecrease in BAT-dependent thermogenesis, whereas treatment with A(2A) agonists significantly increases energy expenditure. Moreover, pharmacological stimulation of A(2A) receptors or injection of lentiviral vectors expressing the A(2A) receptor into white fat induces brown-like cells-so-called beige adipocytes. Importantly, mice fed a high-fat diet and treated with an A(2A) agonist are leaner with improved glucose tolerance. Taken together, our results demonstrate that adenosine-A(2A) signalling plays an unexpected physiological role in sympathetic BAT activation and protects mice from diet-induced obesity. Those findings reveal new possibilities for developing novel obesity therapies.
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| 9. |
- Kilic, Yakup, et al.
(författare)
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An Experimental Study of UWB Device-Free Person Detection and Ranging
- 2013
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Ingår i: 2013 IEEE International Conference on Ultra-Wideband, ICUWB 2013; Sydney, NSW; Australia; 15 September 2013 through 18 September 2013. - 9781479909698 ; , s. 43-48
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Konferensbidrag (refereegranskat)abstract
- Passive person detection and localization is an emerging area in UWB localization systems, whereby people are not required to carry any UWB ranging device. Based on experimental data, we propose a novel method to detect static persons in the absence of template waveforms, and to compute distances to these persons. Our method makes very little assumptions on the environment and can achieve ranging performances on the order of 50 cm, using off-the-shelf UWB devices.
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| 10. |
- Kilic, Yakup, et al.
(författare)
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Device-Free Person Detection and Ranging in UWB Networks
- 2014
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Ingår i: IEEE Journal on Selected Topics in Signal Processing. - : Institute of Electrical and Electronics Engineers (IEEE). - 1941-0484 .- 1932-4553. ; 8:1, s. 43-54
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Tidskriftsartikel (refereegranskat)abstract
- We present a novel device-free stationary person detection and ranging method, that is applicable to ultra-wide bandwidth (UWB) networks. The method utilizes a fixed UWB infrastructure and does not require a training database of template waveforms. Instead, the method capitalizes on the fact that a human presence induces small low-frequency variations that stand out against the background signal, which is mainly affected by wideband noise. We analyze the detection probability, and validate our findings with numerical simulations and experiments with off-the-shelf UWB transceivers in an indoor environment.
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