| 1. |
- Kim, Joon Tae, et al.
(författare)
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Dual antiplatelet Use for extended period taRgeted to AcuTe ischemic stroke with presumed atherosclerotic OrigiN (DURATION) trial : Rationale and design
- 2023
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Ingår i: International Journal of Stroke. - : SAGE Publications. - 1747-4930 .- 1747-4949. ; 18:8, s. 1015-1020
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Tidskriftsartikel (refereegranskat)abstract
- Rationale: The optimal duration of dual antiplatelet therapy (DAPT) with clopidogrel-aspirin for the large artery atherosclerotic (LAA) stroke subtype has been debated. Aims: To determine whether the 1-year risk of recurrent vascular events could be reduced by a longer duration of DAPT in patients with the LAA stroke subtype. Methods and study design: A total of 4806 participants will be recruited to detect a statistically significant relative risk reduction of 22% with 80% power and a two-sided alpha error of 0.05, including a 10% loss to follow-up. This is a registry-based, multicenter, prospective, randomized, open-label, blinded end point study designed to evaluate the efficacy and safety of a 12-month duration of DAPT compared with a 3-month duration of DAPT in the LAA stroke subtype. Patients will be randomized (1:1) to either DAPT for 12 months or DAPT for 3 months, followed by monotherapy (either aspirin or clopidogrel) for the remaining 9 months. Study outcomes: The primary efficacy outcome of the study is a composite of stroke (ischemic or hemorrhagic), myocardial infarction, and all-cause mortality for 1 year after the index stroke. The secondary efficacy outcomes are (1) stroke, (2) ischemic stroke or transient ischemic attack, (3) hemorrhagic stroke, and (4) all-cause mortality. The primary safety outcome is major bleeding. Discussion: This study will help stroke physicians determine the appropriate duration of dual therapy with clopidogrel-aspirin for patients with the LAA stroke subtype. Trial registration: URL: https://cris.nih.go.kr/cris. CRIS Registration Number: KCT0004407.
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| 2. |
- Kim, Jong Hyuk, et al.
(författare)
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Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions
- 2021
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Ingår i: Molecular Cancer Research. - : American Association For Cancer Research (AACR). - 1541-7786 .- 1557-3125. ; 19:5, s. 847-861
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Tidskriftsartikel (refereegranskat)abstract
- Sporadic angiosarcomas are aggressive vascular sarcomas whose rarity and genomic complexity present significant obstacles in deciphering the pathogenic significance of individual genetic alterations. Numerous fusion genes have been identified across multiple types of cancers, but their existence and significance remain unclear in sporadic angiosarcomas. In this study, we leveraged RNA-sequencing data from 13 human angiosarcomas and 76 spontaneous canine hemangiosarcomas to identify fusion genes associated with spontaneous vascular malignancies. Ten novel protein-coding fusion genes, including TEX2-PECAM1 and ATP8A2-FLT1, were identified in seven of the 13 human tumors, with two tumors showing mutations of TP53. HRAS and NRAS mutations were found in angiosarcomas without fusions or TP53 mutations. We found 15 novel protein-coding fusion genes including MYO16-PTK2, GABRA3-FLT1, and AKT3-XPNPEP1 in 11 of the 76 canine hemangiosarcomas; these fusion genes were seen exclusively in tumors of the angiogenic molecular subtype that contained recurrent mutations in TP53, PIK3CA, PIK3R1, and NRAS. In particular, fusion genes and mutations of TP53 cooccurred in tumors with higher frequency than expected by random chance, and they enriched gene signatures predicting activation of angiogenic pathways. Comparative transcriptomic analysis of human angiosarcomas and canine hemangiosarcomas identified shared molecular signatures associated with activation of PI3K/AKT/mTOR pathways. Our data suggest that genome instability induced by TP53 mutations might create a predisposition for fusion events that may contribute to tumor progression by promoting selection and/or enhancing fitness through activation of convergent angiogenic pathways in this vascular malignancy. Implications: This study shows that, while drive events of malignant vasoformative tumors of humans and dogs include diverse mutations and stochastic rearrangements that create novel fusion genes, convergent transcriptional programs govern the highly conserved morphologic organization and biological behavior of these tumors in both species.
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| 3. |
- Biswas, Deepnarayan, et al.
(författare)
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Ultrafast Triggering of Insulator-Metal Transition in Two-Dimensional VSe2
- 2021
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Ingår i: Nano Letters. - : American Chemical Society (ACS). - 1530-6984 .- 1530-6992. ; 21:5, s. 1968-1975
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Tidskriftsartikel (refereegranskat)abstract
- The transition-metal dichalcogenide VSe2 exhibits an increased charge density wave transition temperature and an emerging insulating phase when thinned to a single layer. Here, we investigate the interplay of electronic and lattice degrees of freedom that underpin these phases in single-layer VSe2 using ultrafast pump-probe photoemission spectroscopy. In the insulating state, we observe a light-induced closure of the energy gap, which we disentangle from the ensuing hot carrier dynamics by fitting a model spectral function to the time-dependent photoemission intensity. This procedure leads to an estimated time scale of 480 fs for the closure of the gap, which suggests that the phase transition in single-layer VSe2 is driven by electron-lattice interactions rather than by Mott-like electronic effects. The ultrafast optical switching of these interactions in SL VSe2 demonstrates the potential for controlling phase transitions in 2D materials with light.
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| 4. |
- Park, Jong-Sun, et al.
(författare)
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Auroral electrojet activity for long-duration radial interplanetary magnetic field events
- 2023
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Ingår i: Journal of Geophysical Research - Space Physics. - : American Geophysical Union (AGU). - 2169-9380 .- 2169-9402. ; 128:3
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, we provide statistical evidence that the level of solar wind-magnetosphere-ionosphere (SW-M-I) coupling is weaker under radial (Sun-Earth component dominant) interplanetary magnetic field (IMF) conditions than non-radial IMF conditions. This is performed by analyzing auroral electrojet activity (using SuperMAG auroral electrojet indices) in the sunlit and dark ionospheres for long-duration (at least 4 hr) radial IMF events and comparing against the same for long-duration azimuthal (dusk-dawn component dominant) IMF events. We show that the north-south IMF component (IMF Bz) plays a crucial role in controlling the level of auroral electrojet activity as a negative half-wave rectifier even for both IMF orientation categories. However, it is found that the magnitudes of the auroral electrojet indices are generally lower for radial IMF than for azimuthal IMF under similar sets of solar wind (radial bulk velocity and number density) and IMF Bz conditions, regardless of whether these indices are derived in the sunlit or dark regions. Moreover, the efficiency of coupling functions is lower for radial IMF than for azimuthal IMF, implying that increased coupling strength due to the azimuthal IMF component alone cannot well explain weaker auroral electrojets during radial IMF periods. Lastly, the contribution of the radial IMF component itself to auroral electrojet activity is also lower compared to the azimuthal IMF component. Our results suggest that the level of SW-M-I coupling characterized by auroral electrojet activity can be modulated by the radial IMF component, although the effect of this component is weaker than the other two IMF components.
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| 5. |
- Park, Jong-Sun, et al.
(författare)
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Radial Interplanetary Magnetic Field-Induced North-South Asymmetry in the Solar Wind-Magnetosphere-Ionosphere Coupling : A Case Study
- 2022
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Ingår i: Journal of Geophysical Research - Space Physics. - : John Wiley & Sons. - 2169-9380 .- 2169-9402. ; 127:2
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, we present a case study of the radial interplanetary magnetic field (IMF Bx)-induced asymmetric solar wind-magnetosphere-ionosphere (SW-M-I) coupling between the northern and southern polar caps using ground-based and satellite-based data. Under prolonged conditions of strong earthward IMF on 5 March 2015, we find significant discrepancies between polar cap north (PCN) and polar cap south (PCS) magnetic indices with a negative bay-like change in the PCN and a positive bay-like change in the PCS. The difference between these indices (PCN-PCS) reaches a minimum of −1.63 mV/m, which is approximately three times higher in absolute value than the values for most of the time on this day (within ±0.5 mV/m). The high-latitude plasma convection also shows an asymmetric feature such that there exists an additional convection cell near the noon sector in the northern polar cap, but not in the southern polar cap. Meanwhile, negative bays in the north-south component of ground magnetic field perturbations (less than 50 nT) observed in the nightside auroral region of the Northern Hemisphere are accompanied with the brightening and widening of the nightside auroral oval in the Southern Hemisphere, implying a weak, but clear energy transfer to the nightside ionosphere of both hemispheres. After the hemispheric asymmetries in the polar caps disappear, a substorm onset takes place. All these observations indicate that IMF Bx-induced single lobe reconnection that occurred in the Northern Hemisphere plays an important role in hemispheric asymmetry in the energy transfer from the solar wind to the polar cap through the magnetosphere.
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| 6. |
- Park, Jong-Sun, et al.
(författare)
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Statistical features of polar cap North and South indices in response to interplanetary and terrestrial conditions : a revisit
- 2024
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Ingår i: Space Weather. - : American Geophysical Union (AGU). - 1542-7390. ; 22:4
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Tidskriftsartikel (refereegranskat)abstract
- In this study, we investigate statistical features of polar cap north (PCN) and south (PCS) indices in response to various interplanetary conditions (interplanetary magnetic field [IMF] orientation in three-dimensions) and terrestrial conditions (seasonal and magnetic local time [MLT] locations of the index stations). The concurrent PCN-PCS pairs for 1998–2002 and 2004–2018 are divided based on their sign type (positive-positive, negative-negative, negative-positive, and positive-negative PCN-PCS pairs) and time coverage (the times when both index stations are in the dawn/dusk MLT sector during northern summer/winter). Analyzing the IMF orientation dependence on the occurrence probabilities of concurrent indices and on the differences between the indices in various sign types for each time coverage reveals that the statistical features in PCN-PCS pairs obtained in the dawn MLT sector can be largely explained by the effects of the three-component IMF (related to the polar cap convection patterns) combined with season (related to the hemispheric asymmetry in solar illumination-induced ionospheric conductance). However, those obtained in the dusk MLT sector are controlled dominantly by seasonal effects rather than IMF orientation effects. Our findings indicate that PCN-PCS pair data provide local views about the solar wind-magnetosphere-ionosphere (SW-M-I) coupling system with different control efficiencies of IMF orientation and season depending on the MLT location of the stations. Therefore, introducing polar cap indices recorded simultaneously at various locations in both hemispheres and analyzing them are strongly required to infer global views of the coupled SW-M-I system in the open field regions with higher confidence.
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| 7. |
- Park, Jong-Sun, et al.
(författare)
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Transpolar Arcs During a Prolonged Radial Interplanetary Magnetic Field Interval
- 2021
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Ingår i: Journal of Geophysical Research - Space Physics. - : John Wiley & Sons. - 2169-9380 .- 2169-9402. ; 126:6
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Tidskriftsartikel (refereegranskat)abstract
- Transpolar arcs (TPAs) are believed to predominantly occur under northward interplanetary magnetic field (IMF) conditions with their hemispheric asymmetry controlled by the Sun-Earth (radial) component of the IMF. In this study, we present observations of TPAs that appear in both the northern and southern hemispheres even during a prolonged interval of radially oriented IMF. The Defense Meteorological Satellite Program (DMSP) F16 and the Thermosphere Ionosphere Mesosphere Energetics and Dynamics (TIMED) satellites observed TPAs on the dawnside polar cap in both hemispheres (one TPA structure in the southern hemisphere and two in the northern hemisphere) during an interval of nearly earthward-oriented IMF on October 29, 2005. The southern hemisphere TPA and one of the northern hemisphere TPAs are associated with electron and ion precipitation and mostly sunward plasma flow (with shears) relative to their surroundings. Meanwhile, the other TPA in the northern hemisphere is associated with an electron-only precipitation and antisunward flow relative to its surroundings. Our observations indicate the following: (a) the TPA formation is not limited to northward IMF conditions; (b) the TPAs can be located on both closed field lines rooted in the polar cap of both hemispheres and open field lines connected to the northward field lines draped over one hemisphere of the magnetopause. We believe that the TPAs presented here are the result of both indirect and direct processes of solar wind energy transfer to the high-latitude ionosphere.
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| 8. |
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