Synthesis, in vivo rhesus monkey biodistribution and in vitro evaluation of a C-11-labelled potent aromatase inhibitor: [N-methyl-C-11]vorozole

• [N-methyl-C-11]Vorozole, a high-affinity aromatase-binding radiotracer, was synthesized through N-methylation of the corresponding nor-vorozole derivative using [C-11]methyl iodide. [N-methyl-C-11]Vorozole was obtained in 53-56% radiochemical yield based

Nyckelord

aromatase; inhibitor; [N-methyl-C-11]vorozole; biodistribution; ADVANCED BREAST-CARCINOMA; POSTMENOPAUSAL PATIENTS; CANCER; AMINOGLUTETHIMIDE; AUTORADIOGRAPHY; BIOSYNTHESIS; MECHANISM; C-11

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vet (ämneskategori)

ovr (ämneskategori)