Sökning: WFRF:(Kjaer Josefin)
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Long-term outcome a...
Long-term outcome after resection and thermal hepatic ablation of pancreatic neuroendocrine tumour liver metastases
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- Kjaer, Josefin (författare)
- Uppsala universitet,Endokrinkirurgi
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- Stålberg, Peter (författare)
- Uppsala universitet,Endokrinkirurgi,Institutionen för medicinska vetenskaper
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- Crona, Joakim (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Endokrinkirurgi,Endokrin tumörbiologi
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- Welin, Staffan (författare)
- Uppsala universitet,Onkologisk endokrinologi,Endokrin onkologi
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- Hellman, Per (författare)
- Uppsala universitet,Endokrinkirurgi,Experimentell kirurgi
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- Thornell, Anders, 1976 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery,Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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- Norlén, Olov (författare)
- Uppsala universitet,Endokrinkirurgi,Endokrin kirurgi
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(creator_code:org_t)
- 2021-07-22
- 2021
- Engelska.
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Ingår i: BJS open. - : Oxford University Press (OUP). - 2474-9842. ; 5:4
- Relaterad länk:
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https://academic.oup...
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
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- BACKGROUND: Pancreatic neuroendocrine tumours (Pan-NETs) are rare tumours that often present with or develop liver metastases. The aim of this retrospective study was to evaluate liver surgery and thermal hepatic ablation (THA) of Pan-NET liver metastases and to compare the outcomes with those of a control group. METHOD: Patients with Pan-NET treated in Uppsala University Hospital and Sahlgrenska University Hospital from 1995-2018 were included. Patient records were scrutinized for baseline parameters, survival, treatment and complications. RESULTS: Some 108 patients met the criteria for inclusion; 57 patients underwent treatment with liver surgery or THA and 51 constitute the control group. Median follow-up was 3.93years. Five-year survival in the liver surgery/THA group was 70.6 (95 per cent c.i. 0.57 to 0.84) per cent versus 42.4 (95 per cent c.i. 40.7 to 59.1) per cent in the control group (P=0.016) and median survival was 9.1 (95 per cent c.i. 6.5 to 11.7) versus 4.3 (95 per cent c.i. 3.4-5.2) years. In a multivariable analysis, surgery or THA was associated with a decreased death-years rate (hazard ratio 0.403 (95 per cent c.i. 0.208 to 0.782, P=0.007). CONCLUSION: Liver surgery and/or THA was associated with longer overall survival in Pan-NET with acceptable mortality and morbidity rates. These treatments should thus be considered in Pan-NET patients with reasonable tumour burden in an intent to alleviate symptoms and to improve survival.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
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