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Expression and sign...
Expression and significance of FXYD-3 protein in gastric adenocarcinoma
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- Zhu, Zhen-Long (författare)
- Hebei Medical University
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- Zhao, Zeng-Ren (författare)
- Hebei Medical University
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- Zhang, Yu (författare)
- Hebei Medical University
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- Yang, Yan-Hong (författare)
- Hebei Medical University
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- Wang, Zheng-Min (författare)
- Hebei Medical University
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- Cui, Dong-Sheng (författare)
- Hebei Medical University
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- Wang, Ming-Wei (författare)
- Hebei Medical University
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- Kleeff, Joerg (författare)
- Technical University of Munich
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- Kayed, Hany (författare)
- University of Heidelberg
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- Yan, Bao-Yong (författare)
- Hebei Medical University
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- Sun, Xiao-Feng (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US
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(creator_code:org_t)
- Ios Press, 2010
- 2010
- Engelska.
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Ingår i: DISEASE MARKERS. - : Ios Press. - 0278-0240. ; 28:2, s. 63-69
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Objective: FXYD-3, also known as Mat-8, is a member of the FXYD protein family. It was reported that this protein can associate with and modify the transport properties of Na, K-ATPase, and may play an important role in a variety of physiological and pathological states. This protein is up-regulated in certain types of cancers (such as breast, prostate and pancreatic cancer), but down-regulated in other types of cancers (such as colon and kidney cancer). No study has been performed in gastric cancer; therefore, the aim of this project was to investigate FXYD-3 expression and its clinicopathological significance in gastric adenocarcinoma. Patients and methods: FXYD-3 protein was examined by immunohistochemistry in normal gastric mucous (n = 29) and gastric adenocarcinoma (n = 51), obtained from surgical resection of gastric cancer patients. Results: FXYD-3 protein was present in the cytoplasm of normal gastric epithelial cells or gastric cancer cells. The rate of FXYD-3 strong expression was significantly higher in cancer (51% of 51) than in normal mucosa (10% of 29, X-2=13.210, p andlt; 0.0001). FXYD-3 expressed strongly in ulcerative/infiltrating types of cancers compared to polypoid/fungating ones (X-2 = 5.765, p = 0.016). However, FXYD-3 expression was not correlated with patients gender, age, tumor size, lymph node status and histological grade (p andgt; 0.05). Conclosion: Up-regulated expression of FXYD-3 protein may be involved in tumourgenesis and invasion of gastric adenocarcinoma.
Nyckelord
- FXYD-3
- gastric cancer
- immunohistochemistry
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Zhu, Zhen-Long
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Zhao, Zeng-Ren
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Zhang, Yu
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Yang, Yan-Hong
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Wang, Zheng-Min
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Cui, Dong-Sheng
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visa fler...
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Wang, Ming-Wei
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Kleeff, Joerg
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Kayed, Hany
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Yan, Bao-Yong
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Sun, Xiao-Feng
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DISEASE MARKERS
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Linköpings universitet