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Träfflista för sökning "WFRF:(Knaapen P.) srt2:(2015-2019)"

Sökning: WFRF:(Knaapen P.) > (2015-2019)

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2.
  • Harms, Hendrik J, et al. (författare)
  • Use of a Single 11C-Meta-Hydroxyephedrine Scan for Assessing Flow-Innervation Mismatches in Patients with Ischemic Cardiomyopathy
  • 2015
  • Ingår i: Journal of Nuclear Medicine. - : Society of Nuclear Medicine. - 0161-5505 .- 1535-5667 .- 2159-662X. ; 56:11, s. 1706-1711
  • Tidskriftsartikel (refereegranskat)abstract
    • UNLABELLED: Mismatch between areas of reduced myocardial blood flow (MBF) and reduced myocardial innervation (defect areas) may be used to estimate the risk for ventricular arrhythmias. The presence of a mismatch zone can be derived using a combined protocol consisting of both an MBF scan and an (11)C-meta-hydroxyephedrine ((11)C-HED) scan. The rate of influx from blood to myocardium (K1) of (11)C-HED is proportional to MBF and can potentially be used as an index for defining MBF defects. The aim of this study was to assess whether K1 derived from an (11)C-HED scan can be used as an index of MBF, potentially allowing for an assessment of MBF-innervation mismatch areas from a single (11)C-HED scan.METHODS: Seventeen patients with known ischemic cardiomyopathy underwent dynamic (15)O-water and (11)C-HED scans. Discrete arterial blood samples were taken during (11)C-HED scans for metabolite correction of the image-derived input function. (11)C-HED influx rate was obtained using a single-tissue-compartment model and compared with transmural MBF (MBFT), defined as MBF as measured with (15)O-water multiplied by perfusable tissue fraction. Defect sizes were obtained from parametric K1 and MBFT images, using 50% of a remote control segment as the cutoff value.RESULTS: There was a significant correlation between MBFT and K1 (y = 0.40x + 0.05 mL·g(-1)·min(-1), r = 0.80, P < 0.001), although K1 was significantly lower than MBFT (slope of the regression line significantly different from 1, P < 0.001). Correlation between MBFT and K1 defect sizes was high (y = 0.89x + 1.38%, r = 0.95, P < 0.001), with no significant difference in mean defect size based on K1 or MBFT (20.9% ± 11.3% and 20.1% ± 10.7% for MBFT and K1, respectively, P = 0.41).CONCLUSION: (11)C-HED influx rate K1 can be used as an alternative to a separate MBF scan for assessing mismatch areas between MBF and myocardial innervation.
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3.
  • Knaapen, P, et al. (författare)
  • Positron emission tomography
  • 2015
  • Ingår i: Advanced Cardiac Imaging. - Dordrecht : Elsevier. - 9781782422822 ; , s. 71-95
  • Bokkapitel (refereegranskat)abstract
    • Positron emission tomography (PET) is a radionuclide imaging technique that allows for noninvasive quantification of biochemical pathways in vivo. Utilizing positron emitting labelled compounds of interest, a myriad of biological processes can be visualized in the human heart. As such, PET has been proven invaluable to the noninvasive investigation of cardiovascular biology and physiology. Assessment of myocardial perfusion and substrate metabolism are of particular value in the evaluation of patients with (suspected) coronary artery disease (CAD) to detect ischemia and myocardial viability. This chapter will outline the fundamental principles of PET and technical considerations of cardiac PET imaging.
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