| 1. |
- Koch, Max, et al.
(författare)
-
Rethinking state-civil society relations
- 2022
-
Ingår i: Degrowth & Strategy : How to bring about social-ecological transformation - How to bring about social-ecological transformation. - 9781906948603 ; , s. 170-181
-
Bokkapitel (refereegranskat)
|
|
| 2. |
- Amare, Azmeraw, et al.
(författare)
-
Association of Polygenic Score and the involvement of Cholinergic and Glutamatergic Pathways with Lithium Treatment Response in Patients with Bipolar Disorder.
- 2023
-
Ingår i: Research square. - : Research Square Platform LLC.
-
Tidskriftsartikel (refereegranskat)abstract
- Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental disorder that affects about 1% of the population worldwide. Nevertheless, lithium is not consistently effective, with only 30% of patients showing a favorable response to treatment. To provide personalized treatment options for bipolar patients, it is essential to identify prediction biomarkers such as polygenic scores. In this study, we developed a polygenic score for lithium treatment response (Li+PGS) in patients with BD. To gain further insights into lithium's possible molecular mechanism of action, we performed a genome-wide gene-based analysis. Using polygenic score modeling, via methods incorporating Bayesian regression and continuous shrinkage priors, Li+PGS was developed in the International Consortium of Lithium Genetics cohort (ConLi+Gen: N=2,367) and replicated in the combined PsyCourse (N=89) and BipoLife (N=102) studies. The associations of Li+PGS and lithium treatment response - defined in a continuous ALDA scale and a categorical outcome (good response vs. poor response) were tested using regression models, each adjusted for the covariates: age, sex, and the first four genetic principal components. Statistical significance was determined at P<����������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������.
|
|
| 3. |
- Amare, Azmeraw T, et al.
(författare)
-
Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder.
- 2023
-
Ingår i: Molecular psychiatry. - 1476-5578. ; 28, s. 5251-5261
-
Tidskriftsartikel (refereegranskat)abstract
- Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental healthdisorder that affects about 1% of the population worldwide. Nevertheless, lithium is not consistently effective, with only 30% of patients showing a favorable response to treatment. To provide personalized treatment options for bipolar patients, it is essential to identify prediction biomarkers such as polygenic scores. In this study, we developed a polygenic score for lithium treatment response (Li+PGS) in patients with BD. To gain further insights into lithium's possible molecular mechanism of action, we performed a genome-wide gene-based analysis. Using polygenic score modeling, via methods incorporating Bayesian regression and continuous shrinkage priors, Li+PGS was developed in the International Consortium of Lithium Genetics cohort (ConLi+Gen: N=2367) and replicated in the combined PsyCourse (N=89) and BipoLife (N=102) studies. The associations of Li+PGS and lithium treatment response - defined in a continuous ALDA scale and a categorical outcome (good response vs. poor response) were tested using regression models, each adjusted for the covariates: age, sex, and the first four genetic principal components. Statistical significance was determined at P<0.05. Li+PGS was positively associated with lithium treatment response in the ConLi+Gen cohort, in both the categorical (P=9.8×10-12, R2=1.9%) and continuous (P=6.4×10-9, R2=2.6%) outcomes. Compared to bipolar patients in the 1st decile of the risk distribution, individuals in the 10th decile had 3.47-fold (95%CI: 2.22-5.47) higher odds of responding favorably to lithium. The results were replicated in the independent cohorts for the categorical treatment outcome (P=3.9×10-4, R2=0.9%), but not for the continuous outcome (P=0.13). Gene-based analyses revealed 36 candidate genes that are enriched in biological pathways controlled by glutamate and acetylcholine. Li+PGS may be useful in the development of pharmacogenomic testing strategies by enabling a classification of bipolar patients according to their response to treatment.
|
|
| 4. |
|
|
| 5. |
- Buch-Hansen, Hubert, et al.
(författare)
-
An Economics of Deep Transformations
- 2023
-
Ingår i: Real-world Economics Review. - 1755-9472. ; :106, s. 42-46
-
Tidskriftsartikel (refereegranskat)abstract
- A wide range of literatures have identified the capitalist organisation of societies, and the capitalist growth imperative central to this organisation, as the root cause of the catastrophic climate and biodiversity crises. Highlighting the need to break with this imperative, a growing community of scholars generally viewed as anti- and postcapitalist, there is no consensus on how precisely to conceptualise degrowth. In recent works we have proposed a conceptualisation according to which it is a process involving deep transformations on four interconnected planes of social being. These are (a) material transactions with nature, (b) social interactions between people, (c) social structure, and (d) the inner being of individuals. In our forthcoming book (Buch-Hansen et al. 2024), we theorise what such transformations entail in and how they can emanate from the sites of civil society, the state and business. In the present contribution we add to this perspective by briefly contemplating what sort of economics could play a positive role for deep transformations to unfold. We start out from the currently dominant perspective in economics, neoclassical economics, arguing that it constitutes an economics of deep degradation inasmuch as it produces harm on each plane of being. We then outline a vision of an economics of deep transformations a philosophically informed and genuinely interdisciplinary and holistic economics that could support change on all four planes.
|
|
| 6. |
- Buch-Hansen, Hubert, et al.
(författare)
-
Deep Transformations : A Theory of Degrowth
- 2024
-
Bok (refereegranskat)abstract
- As a research field, social movement and political project, degrowth is a multi-faceted phenomenon. It brings together a range of practices including alternative forms of living and initiatives of various kinds in civil society, business and the state. Yet no comprehensive theory of degrowth transformations has so far been developed. Deep transformations fills this gap. It develops a theory of degrowth transformations drawing on insights from multiple fields of knowledge, such as political economy, sociology and philosophy. The book offers a holistic perspective that brings into focus transformation processes on various scales and points to various mechanisms that can facilitate degrowth. These include ecosocial policies, transformative initiatives in business and civil society and alternative modes of being in and relating to the world.
|
|
| 7. |
- Buchs, Milena, et al.
(författare)
-
Sustainable Welfare: Decoupling Welfare from Growth and Prioritising Needs Satisfaction for All
- 2024
-
Ingår i: De Gruyter Handbook of Degrowth. - Berlin; Boston : De Gruyter. - 9783110778038 - 9783110778359 ; , s. 89-104
-
Bokkapitel (refereegranskat)abstract
- Welfare capitalism has developed in the context of rapidly expanding, fossil fuel-driven industrial economies. Faced with the urgent need for systematic changes of economic systems so that they stay within planetary limits, decoupling welfare from economic growth is an important task. This chapter introduces the concept of sustainable welfare, referring to welfare systems that prioritise the satisfaction of human needs within planetary boundaries. Rather than aligning with the growth imperative through income protection schemes for the socio-economically marginalised and investments in human capital equipped for globalised and competitive economies, sustainable welfare states would prioritise eco-social policies, aiming at basic needs satisfaction for all, limiting excessive consumption behaviours and restricting income and wealth inequalities that have been exacerbated in recent decades. The chapter discusses the ways in which the mutual dependency between welfare systems and economic growth can be decreased by addressing the work and welfare nexus, shifting funding sources for welfare systems, strengthening preventive functions of welfare and redefining the chief goal of welfare systems as sustainable needs satisfaction for all. The chapter further discusses how the governance of this transition process to sustainable welfare can be envisioned, where multi-level governance models and deliberative processes will play a crucial role.
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
|
|
