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- Bousquet, J., et al.
(författare)
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Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)
- 2016
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Ingår i: Clinical and Translational Allergy. - : Wiley. - 2045-7022. ; 6:1, s. 1-18
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Forskningsöversikt (refereegranskat)abstract
- Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases as a model. The chronic respiratory disease action plan includes (1) AIRWAYS integrated care pathways (ICPs), (2) the joint initiative between the Reference site MACVIA-LR (Contre les MAladies Chroniques pour un VIeillissement Actif) and ARIA (Allergic Rhinitis and its Impact on Asthma), (3) Commitments for Action to the European Innovation Partnership on Active and Healthy Ageing and the AIRWAYS ICPs network. It is deployed in collaboration with the World Health Organization Global Alliance against Chronic Respiratory Diseases (GARD). The European Innovation Partnership on Active and Healthy Ageing has proposed a 5-step framework for developing an individual scaling up strategy: (1) what to scale up: (1-a) databases of good practices, (1-b) assessment of viability of the scaling up of good practices, (1-c) classification of good practices for local replication and (2) how to scale up: (2-a) facilitating partnerships for scaling up, (2-b) implementation of key success factors and lessons learnt, including emerging technologies for individualised and predictive medicine. This strategy has already been applied to the chronic respiratory disease action plan of the European Innovation Partnership on Active and Healthy Ageing.
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| 2. |
- Bousquet, J., et al.
(författare)
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MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation
- 2015
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Ingår i: Allergy. European Journal of Allergy and Clinical Immunology. - : WILEY-BLACKWELL. - 0105-4538 .- 1398-9995. ; 70:11, s. 1372-1392
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Tidskriftsartikel (refereegranskat)abstract
- Several unmet needs have been identified in allergic rhinitis: identification of the time of onset of the pollen season, optimal control of rhinitis and comorbidities, patient stratification, multidisciplinary team for integrated care pathways, innovation in clinical trials and, above all, patient empowerment. MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for allergic rhinitis) is a simple system centred around the patient which was devised to fill many of these gaps using Information and Communications Technology (ICT) tools and a clinical decision support system (CDSS) based on the most widely used guideline in allergic rhinitis and its asthma comorbidity (ARIA 2015 revision). It is one of the implementation systems of Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA). Three tools are used for the electronic monitoring of allergic diseases: a cell phone-based daily visual analogue scale (VAS) assessment of disease control, CARAT (Control of Allergic Rhinitis and Asthma Test) and e-Allergy screening (premedical system of early diagnosis of allergy and asthma based on online tools). These tools are combined with a clinical decision support system (CDSS) and are available in many languages. An e-CRF and an e-learning tool complete MASK. MASK is flexible and other tools can be added. It appears to be an advanced, global and integrated ICT answer for many unmet needs in allergic diseases which will improve policies and standards.
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| 5. |
- Koffi, E. N., et al.
(författare)
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Investigating the usefulness of satellite-derived fluorescence data in inferring gross primary productivity within the carbon cycle data assimilation system
- 2015
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Ingår i: Biogeosciences. - : Copernicus GmbH. - 1726-4189. ; 12:13, s. 4067-4084
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Tidskriftsartikel (refereegranskat)abstract
- Simulations of carbon fluxes with terrestrial biosphere models still exhibit significant uncertainties, in part due to the uncertainty in model parameter values. With the advent of satellite measurements of solar induced chlorophyll fluorescence (SIF), there exists a novel pathway for constraining simulated carbon fluxes and parameter values. We investigate the utility of SIF in constraining gross primary productivity (GPP). As a first test we assess whether SIF simulations are sensitive to important parameters in a biosphere model. SIF measurements at the wavelength of 755 nm are simulated by the Carbon-Cycle Data Assimilation System (CCDAS) which has been augmented by the fluorescence component of the Soil Canopy Observation, Photochemistry and Energy fluxes (SCOPE) model. Idealized sensitivity tests of the SCOPE model stand-alone indicate strong sensitivity of GPP to the carboxylation capacity (V-cmax) and of SIF to the chlorophyll AB content (C-ab) and incoming short wave radiation. Low sensitivity is found for SIF to V-cmax, however the relationship is subtle, with increased sensitivity under high radiation conditions and lower V-cmax ranges. CCDAS simulates well the patterns of satellite-measured SIF suggesting the combined model is capable of ingesting the data. CCDAS supports the idealized sensitivity tests of SCOPE, with SIF exhibiting sensitivity to C-ab and incoming radiation, both of which are treated as perfectly known in previous CCDAS versions. These results demonstrate the need for careful consideration of C-ab and incoming radiation when interpreting SIF and the limitations of utilizing SIF to constrain V-cmax in the present set-up in the CCDAS system.
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