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- Assenhöj, Maria, et al.
(författare)
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Occupational exposure and health surveys at metal additive manufacturing facilities
- 2023
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Ingår i: Frontiers in Public Health. - : FRONTIERS MEDIA SA. - 2296-2565. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Additive manufacturing is a novel state-of-the art technology withsignificant economic and practical advantages, including the ability to producecomplex structures on demand while reducing the need of stocking materials andproducts. Additive manufacturing is a technology that is here to stay; however,new technologies bring new challenges, not only technical but also from anoccupational health and safety perspective. Herein, leading Swedish companiesusing metal additive manufacturing were studied with the aim of investigatingoccupational exposure and the utility of chosen exposure- and clinical markersas predictors of potential exposure-related health risks.Methods: Exposure levels were investigated by analysis of airborne dust andmetals, alongside particle counting instruments measuring airborne particles inthe range of 10 nm-10µm to identify dusty work tasks. Health examinationswere performed on a total of 48 additive manufacturing workers and 39 controls.All participants completed a questionnaire, underwent spirometry, and blood andurine sampling. A subset underwent further lung function tests.Results: Exposure to inhalable dust and metals were low, but particle countinginstruments identified specific work tasks with high particle emissions. Examinedhealth parameters were well within reference values on a group level. However,statistical analysis implied an impact on workers kidney function and possibleairway inflammation.Conclusion: The methodology was successful for investigating exposure-relatedhealth risks in additive manufacturing. However, most participants have beenworking <5 years. Therefore, long-term studies are needed before we canconclusively accept or reject the observed e
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| 2. |
- Emilsson, Össur Ingi, et al.
(författare)
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Exhaled biomarkers in adults with non-productive cough
- 2023
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Ingår i: Respiratory Research. - : BioMed Central (BMC). - 1465-9921 .- 1465-993X. ; 24:1
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundChronic cough is a common condition but disease mechanisms are not fully understood. Our aim was to study respiratory biomarkers from the small airways in individuals with non-productive cough.MethodsA cohort of 107 participants answered detailed questionnaires, performed spirometry, exhaled NO measurement, impulse oscillometry, gave blood samples and particles in exhaled air (PEx) samples. Current smokers (N = 38) were excluded. A total of 14 participants reported non-productive cough (cases). A total of 55 participants reported no cough (control group). PEx samples, containing exhaled particles derived from small airways, were collected and analysed with the SOMAscan proteomics platform.ResultsParticipants with non-productive cough had similar age, sex, BMI, and inflammation markers in blood tests, as participants without cough. The proteomics analysis found 75 proteins significantly altered among participants with chronic cough compared to controls, after adjusting for sex and investigator performing the PExA measurement (all with p-value < 0.05 and q-value ≤ 0.13, thereof 21 proteins with a q-value < 0.05). These proteins were mostly involved in immune and inflammatory responses, complement and coagulation system, but also tight junction proteins and proteins involved in neuroinflammatory responses.ConclusionsThis exploratory study on proteomics of exhaled particles among individuals with chronic cough found alterations in relative abundance of 75 proteins. The proteins identified are implicated in both pathways known to be implicated in cough, but also potentially new pathways. Further studies are needed to explore the importance of these findings.
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| 3. |
- Kokelj, Spela, 1992, et al.
(författare)
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Activation of the Complement and Coagulation Systems in the Small Airways in Asthma
- 2023
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Ingår i: Respiration. - : S. Karger. - 0025-7931 .- 1423-0356. ; 102:8, s. 621-631
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Tidskriftsartikel (refereegranskat)abstract
- Background: Several studies have shown the importance of the complement and coagulation systems in the pathogenesis of asthma. Objectives: We explored whether we could detect differentially abundant complement and coagulation proteins in the samples obtained from the small airway lining fluid by collection of exhaled particles in patients with asthma and whether these proteins are associated with small airway dysfunction and asthma control. Method: Exhaled particles were obtained from 20 subjects with asthma and 10 healthy controls (HC) with the PExA method and analysed with the SOMAscan proteomics platform. Lung function was assessed by nitrogen multiple breath washout test and spirometry. Results: 53 proteins associated with the complement and coagulation systems were included in the analysis. Nine of those proteins were differentially abundant in subjects with asthma as compared to HC, and C3 was significantly higher in inadequately controlled asthma as compared to well-controlled asthma. Several proteins were associated with physiological tests assessing small airways. Conclusions: The study highlights the role of the local activation of the complement and coagulation systems in the small airway lining fluid in asthma and their association with both asthma control and small airway dysfunction. The findings highlight the potential of complement factors as biomarkers to identify different sub-groups among patients with asthma that could potentially benefit from a therapeutic approach targeting the complement system.
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