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Stool Microbiota Co...
Stool Microbiota Composition Differs in Patients with Stomach, Colon, and Rectal Neoplasms
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- Youssef, Omar (författare)
- Univ Helsinki, Fac Med, Dept Pathol, Haartmaninkatu 3,POB 21, FIN-00014 Helsinki, Finland
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- Lahti, Leo (författare)
- Univ Turku, Dept Math & Stat, Turku 20014, Finland
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- Kokkola, Arto (författare)
- Univ Cent Hosp Helsinki, HUCH Gastrointestinal Clin, Helsinki 00290, Finland
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- Karla, Tiina (författare)
- Thermo Fisher Sci Co, Vantaa 01620, Finland
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- Tikkanen, Milja (författare)
- Thermo Fisher Sci Co, Vantaa 01620, Finland
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- Ehsan, Homa (författare)
- Univ Helsinki, Fac Med, Dept Pathol, Haartmaninkatu 3,POB 21, FIN-00014 Helsinki, Finland
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- Carpelan-Holmstrom, Monika (författare)
- Univ Cent Hosp Helsinki, HUCH Gastrointestinal Clin, Helsinki 00290, Finland
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- Koskensalo, Selja (författare)
- Univ Cent Hosp Helsinki, HUCH Gastrointestinal Clin, Helsinki 00290, Finland
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- Bohling, Tom (författare)
- Univ Helsinki, Dept Pathol, FIN-00014 Helsinki, Finland;Helsinki Univ Hosp, HUSLAB, Helsinki 00014, Finland
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- Rautelin, Hilpi (författare)
- Uppsala universitet,Klinisk mikrobiologi
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- Puolakkainen, Pauli (författare)
- Univ Cent Hosp Helsinki, HUCH Gastrointestinal Clin, Helsinki 00290, Finland
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- Knuutila, Sakari (författare)
- Univ Helsinki, Fac Med, Dept Pathol, Haartmaninkatu 3,POB 21, FIN-00014 Helsinki, Finland
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- Sarhadi, Virinder (författare)
- Univ Helsinki, Fac Med, Dept Pathol, Haartmaninkatu 3,POB 21, FIN-00014 Helsinki, Finland
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(creator_code:org_t)
- 2018-07-11
- 2018
- Engelska.
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Ingår i: Digestive Diseases and Sciences. - : SPRINGER. - 0163-2116 .- 1573-2568. ; 63:11, s. 2950-2958
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://link.springe...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BackgroundMicrobial ecosystems that inhabit the human gut form central component of our physiology and metabolism, regulating and modulating both health and disease. Changes or disturbances in the composition and activity of this gut microbiota can result in altered immunity, inflammation, and even cancer.AimTo compare the composition and diversity of gut microbiota in stool samples from patient groups based on the site of neoplasm in the gastrointestinal tract (GIT) and to assess the possible contribution of the bacterial composition to tumorigenesis.MethodsWe studied gut microbiota by16S RNA gene sequencing from stool DNA of 83 patients, who were diagnosed with different GIT neoplasms, and 13 healthy individuals.ResultsAs compared to healthy individuals, stools of patients with stomach neoplasms had elevated levels of Enterobacteriaceae, and those with rectal neoplasms had lower levels of Bifidobacteriaceae. Lower abundance of Lactobacillaceae was seen in patients with colon neoplasms. Abundance of Lactobacillaceae was higher in stools of GIT patients sampled after cancer treatment compared to samples collected before start of any treatment. In addition to site-specific differences, higher abundances of Ruminococcus, Subdoligranulum and lower abundances of Lachnoclostridium and Oscillibacter were observed in overall GIT neoplasms as compared to healthy controlsConclusionOur study demonstrates that the alterations in gut microbiota vary according to the site of GIT neoplasm. The observed lower abundance of two common families, Lactobacillaceae and Bifidobacteriaceae, and the increased abundance of Enterobacteriaceae could provide indicators of compromised gut health and potentially facilitate GIT disease monitoring.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Fecal microbiota
- Gastrointestinal neoplasms
- 16S rRNA gene sequencing
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- art (ämneskategori)
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Youssef, Omar
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Lahti, Leo
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Kokkola, Arto
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Karla, Tiina
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Tikkanen, Milja
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Ehsan, Homa
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Carpelan-Holmstr ...
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Koskensalo, Selj ...
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Bohling, Tom
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Rautelin, Hilpi
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Puolakkainen, Pa ...
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Knuutila, Sakari
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Sarhadi, Virinde ...
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och Klinisk medicin
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Uppsala universitet