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IgE cross reactivit...
IgE cross reactivity between reindeer and bovine milk beta-lactoglobulins in cow's milk allergic patients
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Suutari, T. J. (författare)
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Valkonen, K. H. (författare)
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Karttunen, T. J. (författare)
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visa fler...
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Ehn, B. M. (författare)
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Ekstrand, B. (författare)
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- Bengtsson, Ulf, 1944 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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Virtanen, V. (författare)
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Nieminen, M. (författare)
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Kokkonen, J. (författare)
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(creator_code:org_t)
- 2006
- 2006
- Engelska.
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Ingår i: J Investig Allergol Clin Immunol. - 1018-9068. ; 16:5, s. 296-302
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- BACKGROUND: Allergic reactions to cow's milk are common in small children. One of the main protein allergens found in cow's milk is beta-lactoglobulin (beta-Lg). Reindeer and bovine milk both contain related beta-Lg proteins, but the allergenicity of reindeer beta-Lg has not previously been studied. The purpose of this study was to analyze the immunological cross-reactivity of IgE antibodies from children with cow's milk allergy to reindeer and bovine beta-Lg. METHODS: Sera from 17 children and a serum pool of 4 patients with elevated cow's milk-specific IgE were investigated. Beta-Lg from bovine and reindeer milk was isolated in native form and an enzyme-linked immunosorbent inhibition assay was developed. Bovine beta-Lg was used as a capturing antigen and the inhibiting effects of reindeer and bovine beta-Lg on the IgE binding were measured. RESULTS: Cross-reactivity patterns of bovine milk beta-Lg specific IgE to reindeer beta-Lg varied among patients. In general, reindeer beta-Lg showed significantly lower inhibition (mean 43%) of IgE binding to the capturing antigen than did bovine beta-Lg (mean 89%). In some patients, even high concentrations of reindeer beta-Lg only partly eliminated the IgE binding to bovine beta-Lg. CONCLUSIONS: The partial cross-reactivity of human anti-bovine IgE with reindeer beta-Lg suggests that it lacks important bovine epitopes and those that are recognized are only weakly bound.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Animals
- Cattle
- Child
- Child
- Preschool
- Cross Reactions
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Immune Tolerance
- Immunoglobulin E/*immunology
- Infant
- Lactoglobulins/*immunology
- Male
- Milk/*immunology
- Milk Hypersensitivity/*immunology
- Reindeer/*immunology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Suutari, T. J.
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Valkonen, K. H.
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Karttunen, T. J.
-
Ehn, B. M.
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Ekstrand, B.
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Bengtsson, Ulf, ...
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visa fler...
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Virtanen, V.
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Nieminen, M.
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Kokkonen, J.
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visa färre...
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Göteborgs universitet