Sökning: WFRF:(Kondakci Mustafa)
> (2020) >
Clinical spectrum o...
Clinical spectrum of primary adrenal lymphoma: results of a multicenter cohort study
-
- Majidi, Fatemeh (författare)
- Heinrich Heine Univ Dusseldorf, Germany
-
- Martino, Samuela (författare)
- Heinrich Heine Univ Dusseldorf, Germany
-
- Kondakci, Mustafa (författare)
- Heinrich Heine Univ Dusseldorf, Germany
-
visa fler...
-
- Antke, Christina (författare)
- Heinrich Heine Univ Dusseldorf, Germany
-
- Haase, Matthias (författare)
- Heinrich Heine Univ Dusseldorf, Germany
-
- Chortis, Vasileios (författare)
- Birmingham Hlth Partners, England; Univ Birmingham, England
-
- Arlt, Wiebke (författare)
- Birmingham Hlth Partners, England; Univ Birmingham, England
-
- Ronchi, Cristina L. (författare)
- Univ Birmingham, England; Univ Wurzburg, Germany
-
- Fassnacht, Martin (författare)
- Univ Wurzburg, Germany
-
- Laurent, Claire (författare)
- Univ Hosp Dijon, France
-
- Petit, Jean-Michel (författare)
- Univ Hosp Dijon, France
-
- Casasnovas, Olivier (författare)
- Univ Hosp Djion, France
-
- Habra, Amir Mouhammed (författare)
- Univ Texas MD Anderson Canc Ctr, TX 77030 USA
-
- Kanji, Aleem (författare)
- Baylor Coll Med, TX 77030 USA
-
- Salvatori, Roberto (författare)
- Johns Hopkins Univ, MD USA
-
- Nhat Ho, An Thi (författare)
- Medstar Harbor Hosp, MD USA
-
- Spyroglou, Ariadni (författare)
- Univ Spital Zurich, Switzerland
-
- Beuschlein, Felix (författare)
- Univ Spital Zurich, Switzerland; Ludweig Maximilians Univ Munchen, Germany
-
- Villa, Diego (författare)
- BC Canc Ctr Lymphoid Canc, Canada; Univ British Columbia, Canada
-
- Limvorapitak, Wasithep (författare)
- BC Canc Ctr Lymphoid Canc, Canada; Univ British Columbia, Canada; Thammasat Univ, Thailand
-
- Wahlin, Bjoern Engelbrekt (författare)
- Karolinska Institutet
-
- Gimm, Oliver (författare)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US
-
- Rudelius, Martina (författare)
- Ludweig Maximilians Univ Munchen, Germany
-
- Schott, Matthias (författare)
- Heinrich Heine Univ Dusseldorf, Germany
-
- Germing, Ulrich (författare)
- Heinrich Heine Univ Dusseldorf, Germany
-
- Haas, Rainer (författare)
- Heinrich Heine Univ Dusseldorf, Germany
-
- Gattermann, Norbert (författare)
- Heinrich Heine Univ Dusseldorf, Germany
-
visa färre...
-
(creator_code:org_t)
- BIOSCIENTIFICA LTD, 2020
- 2020
- Engelska.
-
Ingår i: European Journal of Endocrinology. - : BIOSCIENTIFICA LTD. - 0804-4643 .- 1479-683X. ; 183:4, s. 453-462
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Purpose: We sought to refine the clinical picture of primary adrenal lymphoma (PAL), a rare lymphoid malignancy with predominant adrenal manifestation and risk of adrenal insufficiency. Methods: Ninety-seven patients from 14 centers in Europe, Canada and the United States were included in this retrospective analysis between 1994 and 2017. Results: Of the 81 patients with imaging data, 19 (23%) had isolated adrenal involvement (iPAL), while 62 (77%) had additional extra-adrenal involvement (PAL+). Among patients who had both CT and PET scans, 18FDG-PET revealed extra-adrenal involvement not detected by CT scan in 9/18 cases (50%). The most common clinical manifestations were B symptoms (55%), fatigue (45%), and abdominal pain (35%). Endocrinological assessment was often inadequate. With a median follow-up of 41.6 months, 3-year progression-free (PFS) and overall (OS) survival rates in the entire cohort were 35.5% and 39.4%, respectively. The hazard ratios of iPAL for PFS and OS were 40.1 (95% CI: 2.63-613.7, P = 0.008) and 2.69 (95% CI: 0.61-11.89, P = 0.191), respectively. PFS was much shorter in iPAL vs PAL+ (median 4 months vs not reached, P = 0.006), and OS also appeared to be shorter (median 16 months vs not reached), but the difference did not reach statistical significance (P = 0.16). Isolated PAL was more frequent in females (OR = 3.81; P = 0.01) and less frequently associated with B symptoms (OR = 0.159; P = 0.004). Conclusion: We found unexpected heterogeneity in the clinical spectrum of PAL. Further studies are needed to clarify whether clinical distinction between iPAL and PAL+ is corroborated by differences in molecular biology.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Majidi, Fatemeh
-
Martino, Samuela
-
Kondakci, Mustaf ...
-
Antke, Christina
-
Haase, Matthias
-
Chortis, Vasilei ...
-
visa fler...
-
Arlt, Wiebke
-
Ronchi, Cristina ...
-
Fassnacht, Marti ...
-
Laurent, Claire
-
Petit, Jean-Mich ...
-
Casasnovas, Oliv ...
-
Habra, Amir Mouh ...
-
Kanji, Aleem
-
Salvatori, Rober ...
-
Nhat Ho, An Thi
-
Spyroglou, Ariad ...
-
Beuschlein, Feli ...
-
Villa, Diego
-
Limvorapitak, Wa ...
-
Wahlin, Bjoern E ...
-
Gimm, Oliver
-
Rudelius, Martin ...
-
Schott, Matthias
-
Germing, Ulrich
-
Haas, Rainer
-
Gattermann, Norb ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kirurgi
- Artiklar i publikationen
-
European Journal ...
- Av lärosätet
-
Linköpings universitet
-
Karolinska Institutet