SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Kopecký Martin) srt2:(2012-2014)"

Sökning: WFRF:(Kopecký Martin) > (2012-2014)

  • Resultat 1-2 av 2
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Rossmeisl, Martin, et al. (författare)
  • Metabolic effects of n-3 PUFA as phospholipids are superior to triglycerides in mice fed a high-fat diet: Possible role of endocannabinoids
  • 2012
  • Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 7
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: n-3 polyunsaturated fatty acids, namely docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), reduce the risk of cardiovascular disease and can ameliorate many of obesity-associated disorders. We hypothesised that the latter effect will be more pronounced when DHA/EPA is supplemented as phospholipids rather than as triglycerides. Methodology/Principal Findings: In a 'prevention study', C57BL/6J mice were fed for 9 weeks on either a corn oil-based high-fat obesogenic diet (cHF; lipids ~35% wt/wt), or cHF-based diets in which corn oil was partially replaced by DHA/EPA, admixed either as phospholipids or triglycerides from marine fish. The reversal of obesity was studied in mice subjected to the preceding cHF-feeding for 4 months. DHA/EPA administered as phospholipids prevented glucose intolerance and tended to reduce obesity better than triglycerides. Lipemia and hepatosteatosis were suppressed more in response to dietary phospholipids, in correlation with better bioavailability of DHA and EPA, and a higher DHA accumulation in the liver, white adipose tissue (WAT), and muscle phospholipids. In dietary obese mice, both DHA/EPA concentrates prevented a further weight gain, reduced plasma lipid levels to a similar extent, and tended to improve glucose tolerance. Importantly, only the phospholipid form reduced plasma insulin and adipocyte hypertrophy, while being more effective in reducing hepatic steatosis and low-grade inflammation of WAT. These beneficial effects were correlated with changes of endocannabinoid metabolome in WAT, where phospholipids reduced 2-arachidonoylglycerol, and were more effective in increasing anti-inflammatory lipids such as N-docosahexaenoylethanolamine. Conclusions/Significance: Compared with triglycerides, dietary DHA/EPA administered as phospholipids are superior in preserving a healthy metabolic profile under obesogenic conditions, possibly reflecting better bioavalability and improved modulation of the endocannabinoid system activity in WAT. © 2012 Rossmeisl et al.
  •  
2.
  • Tønnesen, Hanne, et al. (författare)
  • Handling Clinical Health Promotion in the HPH DATA MODEL: Basic Documentation of Health Determinants in Medical Records of tobacco, malnutrition, overweight, physical inactivity & alcohol
  • 2012
  • Ingår i: Clinical Health Promotion. - 2226-5864. ; 2:1, s. 5-11
  • Tidskriftsartikel (refereegranskat)abstract
    • BackgroundClinical Health Promotion activities contribute to the reduction of disease and treatment, and improve outcomes and prognosis. Accordingly, major health determinants such as smoking, physical inactivity, risk of malnutrition, overweight and hazardous drinking should be easily identified in the medical records. To that end, this study evaluates a simple 9 question health documentation model (HPH DATA Model) to be used in the medical records of patients in need of health promotion. MethodsThe multi-national study took place in 78 pilot centres from 12 nations / regions. First, the HPH DATA Model was pilot tested by clinical specialists in a standardised manner for control under international conditions (A). Then it was tested under local conditions (B). After gaining familiarity with the model, the clinical specialists evaluated whether the model was understandable, applicable and sufficient (C). They were also invited to give comments. ResultsThe response rate was 87-100%; the missing data among responders were 0 - 2.6%. The inter-rater agreement in documenting the 5 risk factors using the HPH DATA Model was substantial to nearly perfect across the pilot centres at International Conditions (A); Kappa value 0.85 (0.65 - 0.99). The clinical specialists categorized 66% (29 - 94%) of the patients from their own clinical practice regarding the need for health promotion (B). Except for waist measure-ments, the clinical specialists found the model understandable, applicable and sufficient. It was also determined that the clinical specialists were in need of a more comprehensive definition of the term “severe illness” (C).ConclusionsThe simple HPH DATA Model for systematic registration of 5 significant health determinants was found to be understandable, applicable and sufficient in different clinical settings.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-2 av 2

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy