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- 2017
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Ingår i: Physical Review D. - 2470-0010 .- 2470-0029. ; 96:2
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Tidskriftsartikel (refereegranskat)
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- Brorson, Håkan, et al.
(författare)
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Circumferential suction-asssisted lipectomy is the only surgical procedure that can normalize large chronic fat-transformed lymphedemas
- 2018
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Ingår i: European Book of Angiology/Vascular Medicine. - 9788825510522 ; , s. 1011-1012
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Bokkapitel (refereegranskat)abstract
- 2.Brorson H. Circumferential suction-asssisted lipectomy is the only surgical procedure that can normalize large chronic fat-transformed lymphedemas. In: Catalano M, Pecsvarady Z, Olinic D, Wautrecht J-C, Gerotziafas G, Amann-Vesti B, Karetova D, Fagrell B, Diehm C, Kozak M, Edmonds M, editors, European Book of Angiology/Vascular Medicine. Milano, Italy: VAS, UNIMI-H Sacco; 2016. Pp XXX-XXX.
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- Kozak, John J., et al.
(författare)
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Geometrical Description of Protein Structural Motifs
- 2018
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Ingår i: Journal of Physical Chemistry B. - : American Chemical Society (ACS). - 1520-5207 .- 1520-6106. ; 122:49, s. 11289-11294
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Tidskriftsartikel (refereegranskat)abstract
- We present a geometrical method that can identify secondary structural motifs in proteins via angular correlations. The method uses crystal structure coordinates to calculate angular and radial signatures of each residue relative to an external reference point as the number of nearest-neighbor residues increases. We apply our approach to the blue copper protein amicyanin using the copper cofactor as the external reference point. We define a signature termed Δβ which describes the change in angular correlation as the span of nearest neighbor residues increases. We find that three turn regions of amicyanin harbor residues with Δβ near zero, while residues in other secondary structures have Δβ greater than zero: for β-strands, Δβ changes gradually residue by residue along the strand. Extension of our analysis to other blue copper proteins demonstrated that the noted structural trends are general. Importantly, our geometrical description of the folded protein accounts for all forces holding the structure together. Through this analysis, we identified some of the turns in amicyanin as symmetrical anchor points.
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- Rutherford, Michael, et al.
(författare)
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Randomised clinical trial assessing migration of uncemented primary total hip replacement stems, with and without autologous impaction bone grafting
- 2019
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Ingår i: International Orthopaedics. - : Springer. - 0341-2695 .- 1432-5195. ; 43:12, s. 2715-2723
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Uncemented stems in primary total hip replacement (THR) are concerning in the elderly due to ectatic femoral canals and cortical thinning resulting in higher incidence of fracture and subsidence in this population. To obviate this concern, the authors developed a technique using autologous impaction bone grafting to achieve a better fitting femoral stem. The aim of this randomised clinical trial was to assess the efficacy of the technique.Methods: From 2013 to 2015, a total of 98 consecutive participants (100 primary THR procedures) were inducted into a single-institution, single-blinded, randomised clinical trial assessing, with radiostereometric analysis (RSA), the efficacy of autologous impaction bone grafting in uncemented primary THR compared with traditional uncemented primary THR technique. The primary outcome measure was femoral component migration using RSA. Secondary outcomes were post-operative proximal femoral bone density (using DEXA), hip function and quality of life using Oxford Hip Score (OHS) and Short Form-12 Health Survey (SF-12), hip pain and patient satisfaction.Results: There was no difference in femoral component stability (p > 0.5) or calcar resorption between the Graft and No Graft Groups at two years. There was also no difference in OHS, SF-12, pain or satisfaction between the Graft and No Graft Groups at two years (p > 0.39).Conclusions: Autologous impaction bone grafting in uncemented primary THR has shown its short-term post-operative outcomes to be equivalent to standard uncemented technique, whilst offering a better fit in patients who are between femoral stem sizes.
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