| 1. |
- Kramer, Sophia E., et al.
(författare)
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Cortisol, Chromogranin A, and Pupillary Responses Evoked by Speech Recognition Tasks in Normally Hearing and Hard-of-Hearing Listeners: A Pilot Study
- 2016
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Ingår i: Ear and Hearing. - : LIPPINCOTT WILLIAMS & WILKINS. - 0196-0202 .- 1538-4667. ; 37, s. 126S-135S
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Tidskriftsartikel (refereegranskat)abstract
- Pupillometry is one method that has been used to measure processing load expended during speech understanding. Notably, speech perception (in noise) tasks can evoke a pupil response. It is not known if there is concurrent activation of the sympathetic nervous system as indexed by salivary cortisol and chromogranin A (CgA) and whether such activation differs between normally hearing (NH) and hard-of-hearing (HH) adults. Ten NH and 10 adults with mild-to-moderate hearing loss (mean age 52 years) participated. Two speech perception tests were administered in random order: one in quiet targeting 100% correct performance and one in noise targeting 50% correct performance. Pupil responses and salivary samples for cortisol and CgA analyses were collected four times: before testing, after the two speech perception tests, and at the end of the session. Participants rated their perceived accuracy, effort, and motivation. Effects were examined using repeated-measures analyses of variance. Correlations between outcomes were calculated. HH listeners had smaller peak pupil dilations (PPDs) than NH listeners in the speech in noise condition only. No group or condition effects were observed for the cortisol data, but HH listeners tended to have higher cortisol levels across conditions. CgA levels were larger at the pretesting time than at the three other test times. Hearing impairment did not affect CgA. Self-rated motivation correlated most often with cortisol or PPD values. The three physiological indicators of cognitive load and stress (PPD, cortisol, and CgA) are not equally affected by speech testing or hearing impairment. Each of them seem to capture a different dimension of sympathetic nervous system activity.
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| 2. |
- Pichora-Fuller, Kathleen M., et al.
(författare)
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Hearing Impairment and Cognitive Energy: The Framework for Understanding Effortful Listening (FUEL)
- 2016
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Ingår i: Ear and Hearing. - : LIPPINCOTT WILLIAMS & WILKINS. - 0196-0202 .- 1538-4667. ; 37, s. 5S-27S
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Tidskriftsartikel (refereegranskat)abstract
- The Fifth Eriksholm Workshop on "Hearing Impairment and Cognitive Energy" was convened to develop a consensus among interdisciplinary experts about what is known on the topic, gaps in knowledge, the use of terminology, priorities for future research, and implications for practice. The general term cognitive energy was chosen to facilitate the broadest possible discussion of the topic. It goes back to Titchener (1908) who described the effects of attention on perception; he used the term psychic energy for the notion that limited mental resources can be flexibly allocated among perceptual and mental activities. The workshop focused on three main areas: (1) theories, models, concepts, definitions, and frameworks; (2) methods and measures; and (3) knowledge translation. We defined effort as the deliberate allocation of mental resources to overcome obstacles in goal pursuit when carrying out a task, with listening effort applying more specifically when tasks involve listening. We adapted Kahnemans seminal (1973) Capacity Model of Attention to listening and proposed a heuristically useful Framework for Understanding Effortful Listening (FUEL). Our FUEL incorporates the well-known relationship between cognitive demand and the supply of cognitive capacity that is the foundation of cognitive theories of attention. Our FUEL also incorporates a motivation dimension based on complementary theories of motivational intensity, adaptive gain control, and optimal performance, fatigue, and pleasure. Using a three-dimensional illustration, we highlight how listening effort depends not only on hearing difficulties and task demands but also on the listeners motivation to expend mental effort in the challenging situations of everyday life.
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| 3. |
- Alfandari, Defne, et al.
(författare)
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Brain Volume Differences Associated With Hearing Impairment in Adults
- 2018
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Ingår i: TRENDS IN HEARING. - : SAGE PUBLICATIONS INC. - 2331-2165. ; 22
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Tidskriftsartikel (refereegranskat)abstract
- Speech comprehension depends on the successful operation of a network of brain regions. Processing of degraded speech is associated with different patterns of brain activity in comparison with that of high-quality speech. In this exploratory study, we studied whether processing degraded auditory input in daily life because of hearing impairment is associated with differences in brain volume. We compared TI-weighted structural magnetic resonance images of 17 hearing-impaired (HI) adults with those of 17 normal-hearing (NH) controls using a voxel-based morphometry analysis. HI adults were individually matched with NH adults based on age and educational level. Gray and white matter brain volumes were compared between the groups by region-of-interest analyses in structures associated with speech processing, and by whole-brain analyses. The results suggest increased gray matter volume in the right angular gyrus and decreased white matter volume in the left fusiform gyrus in HI listeners as compared with NH ones. In the HI group, there was a significant correlation between hearing acuity and cluster volume of the gray matter cluster in the right angular gyrus. This correlation supports the link between partial hearing loss and altered brain volume. The alterations in volume may reflect the operation of compensatory mechanisms that are related to decoding meaning from degraded auditory input.
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| 4. |
- Besser, Jana, et al.
(författare)
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Speech-in-Speech Listening on the LiSN-S Test by Older Adults With Good Audiograms Depends on Cognition and Hearing Acuity at High Frequencies
- 2015
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Ingår i: Ear and Hearing. - : LIPPINCOTT WILLIAMS and WILKINS. - 0196-0202 .- 1538-4667. ; 36:1, s. 24-41
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: The main objective was to investigate age-related differences on the listening in spatialized noise-sentences (LiSN-S) test in adults with normal audiometric thresholds in most of the speech range. A second objective was to examine the contributions of auditory, cognitive, and linguistic abilities to LiSN-S outcomes. Design: The LiSN-S test was administered to participants in an older group (M-Age = 72.0, SD = 4.3 years) and a younger group (M-Age = 21.7, SD = 2.6 years) with N = 26 per group. All the participants had clinically normal audiometric thresholds at frequencies up to and including 3000 Hz. The LiSN-S test yields a speech reception threshold (SRT) in each of the four speech-in-speech listening conditions that differ in the availability of voice difference cues and/or spatial separation cues. Based on these four SRTs, the scores were calculated for the talker advantage, the spatial advantage, and the total advantage as a result of both the types of cues. Additionally, the participants completed four auditory temporal-processing tests, a cognitive screening test, a vocabulary test, and tests of linguistic closure for high-and low-context sentences. The contributions of these predictor variables and measures of pure-tone hearing acuity to LiSN-S outcomes were analyzed for both the groups using regression analyses. Results: Younger listeners outperformed the older listeners on all four LiSN-S SRTs and all the three LiSN-S advantage measures. Age-related differences were larger for conditions involving the use of spatial cues. For the younger group, all LiSN-S SRTs were predicted by the measure of linguistic closure in low-context sentences; in addition, the SRT for the condition with voice difference cues but without spatial separation cues was predicted by vocabulary, and the SRT for the condition with both voice difference cues and spatial separation cues was predicted by temporal resolution at low frequencies. Vocabulary also contributed to the talker advantage in the younger group, whereas the spatial advantage was predicted by high-frequency pure-tone hearing acuity in the range 6,000 to 10,000 Hz (pure-tone average [ PTA] HIGH). For the older group, the LiSN-S SRT in the condition with neither voice difference cues nor spatial separation cues was predicted by age; their other three LiSN-S SRTs and all advantage measures were predicted by PTA HIGH. In addition, for the older group, cognition predicted LiSN-S SRT outcomes in three of the four conditions. Measures of auditory temporal processing, linguistic abilities, or hearing acuity up to and including 4000 Hz did not predict LiSN-S outcomes in this group. Conclusions: LiSN-S outcomes were poorer for adults aged 65 years or older, even those with good audiograms, compared with younger adults and also compared with people up to the age of 60 years from a previous study. In the present study, regardless of the types of cues, auditory and cognitive interactions were reflected by the combined influences on LiSN-S outcomes of high-frequency hearing acuity and measures of linguistic and cognitive processing. The data also suggest a hierarchy in the deployment of processing resources, which would account for the observed shift from linguistic abilities in the younger group to general cognitive abilities in the older group.
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| 5. |
- Hoshino, Ayuko, et al.
(författare)
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Tumour exosome integrins determine organotropic metastasis
- 2015
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Ingår i: Nature. - : NATURE PUBLISHING GROUP. - 0028-0836 .- 1476-4687. ; 527:7578, s. 329-
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Tidskriftsartikel (refereegranskat)abstract
- Ever since Stephen Pagets 1889 hypothesis, metastatic organotropism has remained one of cancers greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver-and brain-tropic tumour cells fuse preferentially with resident cells at their predicted destination, namely lung fibroblasts and epithelial cells, liver Kupffer cells and brain endothelial cells. We show that tumour-derived exosomes uptaken by organ-specific cells prepare the pre-metastatic niche. Treatment with exosomes from lung-tropic models redirected the metastasis of bone-tropic tumour cells. Exosome proteomics revealed distinct integrin expression patterns, in which the exosomal integrins alpha(6)beta(4) and alpha(6)beta(1) were associated with lung metastasis, while exosomal integrin alpha(v)beta(5) was linked to liver metastasis. Targeting the integrins alpha(6)beta(4) and alpha(v)beta(5) decreased exosome uptake, as well as lung and liver metastasis, respectively. We demonstrate that exosome integrin uptake by resident cells activates Src phosphorylation and pro-inflammatory S100 gene expression. Finally, our clinical data indicate that exosomal integrins could be used to predict organ-specific metastasis.
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| 6. |
- Koelewijn, Thomas, et al.
(författare)
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The effect of reward on listening effort as reflected by the pupil dilation response
- 2018
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Ingår i: Hearing Research. - : ELSEVIER SCIENCE BV. - 0378-5955 .- 1878-5891. ; 367, s. 106-112
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Tidskriftsartikel (refereegranskat)abstract
- Listening to speech in noise can be effortful but when motivated people seem to be more persevering. Previous research showed effects of monetary reward on autonomic responses like cardiovascular reactivity and pupil dilation while participants processed auditory information. The current study examined the effects of monetary reward on the processing of speech in noise and related listening effort as reflected by the pupil dilation response. Twenty-four participants (median age 21 yrs) performed two speech reception threshold (SRT) tasks, one tracking 50% correct (hard) and one tracking 85% correct (easy), both of which they listened to and repeated sentences uttered by a female talker. The sentences were presented with a single male talker or, in a control condition, in quiet. Participants were told that they could earn a high (5 euros) or low (0.20 euro) reward when repeating 70% or more of the sentences correctly. Conditions were presented in a blocked fashion and during each trial, pupil diameter was recorded. At the end of each block, participants rated the effort they had experienced, their performance, and their tendency to quit listening. Additionally, participants performed a working memory capacity task and filled in a need-for-recovery questionnaire as these tap into factors that influence the pupil dilation response. The results showed no effect of reward on speech perception performance as reflected by the SRT. The peak pupil dilation showed a significantly larger response for high than for low reward, for the easy and hard conditions, but not the control condition. Higher need for recovery was associated with a higher subjective tendency to quit listening. Consistent with the Framework for Understanding Effortful Listening, we conclude that listening effort as reflected by the peak pupil dilation is sensitive to the amount of monetary reward. (C) 2018 The Authors. Published by Elsevier B.V.
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| 7. |
- Koelewijn, Thomas, et al.
(författare)
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The pupil response reveals increased listening effort when it is difficult to focus attention
- 2015
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Ingår i: Hearing Research. - : Elsevier. - 0378-5955 .- 1878-5891. ; 323, s. 81-90
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Tidskriftsartikel (refereegranskat)abstract
- Recent studies have shown that prior knowledge about where, when, and who is going to talk improves speech intelligibility. How related attentional processes affect cognitive processing load has not been investigated yet. In the current study, three experiments investigated how the pupil dilation response is affected by prior knowledge of target speech location, target speech onset, and who is going to talk. A total of 56 young adults with normal hearing participated. They had to reproduce a target sentence presented to one ear while ignoring a distracting sentence simultaneously presented to the other ear. The two sentences were independently masked by fluctuating noise. Target location (left or right ear), speech onset, and talker variability were manipulated in separate experiments by keeping these features either fixed during an entire block or randomized over trials. Pupil responses were recorded during listening and performance was scored after recall. The results showed an improvement in performance when the location of the target speech was fixed instead of randomized. Additionally, location uncertainty increased the pupil dilation response, which suggests that prior knowledge of location reduces cognitive load. Interestingly, the observed pupil responses for each condition were consistent with subjective reports of listening effort. We conclude that communicating in a dynamic environment like a cocktail party (where participants in competing conversations move unpredictably) requires substantial listening effort because of the demands placed on attentional processes. (C) 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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| 8. |
- Ohlenforst, Barbara, et al.
(författare)
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Effects of hearing aid rehabilitation on listening effort a systematic literature review
- 2015
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Hearing impairment negatively affects speech perception and may increase listening effort, especially under adverse conditions such as in the presence of background noise. Previous research showed that hearing-aid rehabilitation can improve speech perception performance. However, it is not clear whether it influences listening effort during speech perception. The aim of this systematic review is to provide an overview of available evidence of the effect of hearing-aid rehabilitation on listening effort. English language articles were identified through systematic searches in PubMed, EMBASE, Cinahl, the Cochrane Library, PsycINFO and through reference checking from inception to August 2014. The primary search produced 12210 unique hits using the key-words: hearing aids OR hearing impairment AND listening effort OR perceptual effort OR ease of listening. Three researchers independently determined eligibility of the articles. In total, about 45 articles fulfilled the search and selection criteria of: experimental work on hearing aid technologies AND listening effort OR fatigue during speech perception.Most of the about 45 eligible studies (about 70%) measured perceived effort using subjective scales or questionnaires. Behavioral measures of listening effort mainly included dual-task paradigms. Finally, physiological measures such as provided by pupillometry, electroencephalography and functional magnetic resonance imaging objectively estimated listening effort. Some studies found that hearing-aid rehabilitation was associated with significant reductions of listening effort, while others failed to do so or even reported an increase of listening effort associated with hearing-aid rehabilitation.This review summarizes the available evidence on the effects of hearing aid rehabilitation on listening effort.
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| 9. |
- Ohlenforst, Barbara, et al.
(författare)
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Effects of Hearing Impairment and Hearing Aid Amplification on Listening Effort : A Systematic Review
- 2017
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Ingår i: Ear and Hearing. - : Lippincott Williams & Wilkins. - 0196-0202 .- 1538-4667. ; 38:3, s. 267-281
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Forskningsöversikt (refereegranskat)abstract
- Objectives: To undertake a systematic review of available evidence on the effect of hearing impairment and hearing aid amplification on listening effort. Two research questions were addressed: Q1) does hearing impairment affect listening effort? and Q2) can hearing aid amplification affect listening effort during speech comprehension? Design: English language articles were identified through systematic searches in PubMed, EMBASE, Cinahl, the Cochrane Library, and PsyclNFO from inception to August 2014. References of eligible studies were checked. The Population, Intervention, Control, Outcomes, and Study design strategy was used to create inclusion criteria for relevance. It was not feasible to apply a meta-analysis of the results from comparable studies. For the articles identified as relevant, a quality rating, based on the 2011 Grading of Recommendations Assessment, Development, and Evaluation Working Group guidelines, was carried out to judge the reliability and confidence of the estimated effects. Results: The primary search produced 7017 unique hits using the keywords: hearing aids OR hearing impairment AND listening effort OR perceptual effort OR ease of listening. Of these, 41 articles fulfilled the Population, Intervention, Control, Outcomes, and Study design selection criteria of: experimental work on hearing impairment OR hearing aid technologies AND listening effort OR fatigue during speech perception. The methods applied in those articles were categorized into subjective, behavioral, and physiological assessment of listening effort. For each study, the statistical analysis addressing research question Q1 and/or Q2 was extracted. In seven articles more than one measure of listening effort was provided. Evidence relating to Q1 was provided by 21 articles that reported 41 relevant findings. Evidence relating to Q2 was provided by 27 articles that reported 56 relevant findings. The quality of evidence on both research questions (Q1 and Q2) was very low, according to the Grading of Recommendations Assessment, Development, and Evaluation Working Group guidelines. We tested the statistical evidence across studies with nonparametric tests. The testing revealed only one consistent effect across studies, namely that listening effort was higher for hearing-impaired listeners compared with normal-hearing listeners (Q1) as measured by electroencephalographic measures. For all other studies, the evidence across studies failed to reveal consistent effects on listening effort. Conclusion: In summary, we could only identify scientific evidence from physiological measurement methods, suggesting that hearing impairment increases listening effort during speech perception (Q1). There was no scientific, finding across studies indicating that hearing aid amplification decreases listening effort (Q2). In general, there were large differences in the study population, the control groups and conditions, and the outcome measures applied between the studies included in this review. The results of this review indicate that published listening effort studies lack consistency, lack standardization across studies, and have insufficient statistical power. The findings underline the need for a common conceptual framework for listening effort to address the current shortcomings.
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| 10. |
- Ohlenforst, Barbara, et al.
(författare)
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Impact of SNR, masker type and noise reduction processing on sentence recognition performance and listening effort as indicated by the pupil dilation response
- 2018
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Ingår i: Hearing Research. - : ELSEVIER SCIENCE BV. - 0378-5955 .- 1878-5891. ; 365, s. 90-99
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Tidskriftsartikel (refereegranskat)abstract
- Recent studies have shown that activating the noise reduction scheme in hearing aids results in a smaller peak pupil dilation (PPD), indicating reduced listening effort, at 50% and 95% correct sentence recognition with a 4-talker masker. The objective of this study was to measure the effect of the noise reduction scheme (on or off) on PPD and sentence recognition across a wide range of signal-to-noise ratios (SNRs) from +16 dB to -12 dB and two masker types (4-talker and stationary noise). Relatively low PPDs were observed at very low (-12 dB) and very high (+16 dB to +8 dB) SNRs presumably due to giving up and easy listening, respectively. The maximum PPD was observed with SNRs at approximately 50% correct sentence recognition. Sentence recognition with both masker types was significantly improved by the noise reduction scheme, which corresponds to the shift in performance from SNR function at approximately 5 dB toward a lower SNR. This intelligibility effect was accompanied by a corresponding effect on the PPD, shifting the peak by approximately 4 dB toward a lower SNR. In addition, with the 4-talker masker, when the noise reduction scheme was active, the PPD was smaller overall than that when the scheme was inactive. We conclude that with the 4-talker masker, noise reduction scheme processing provides a listening effort benefit in addition to any effect associated with improved intelligibility. Thus, the effect of the noise reduction scheme on listening effort incorporates more than can be explained by intelligibility alone, emphasizing the potential importance of measuring listening effort in addition to traditional speech reception measures. (C) 2018 Elsevier B.V. All rights reserved.
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