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| 2. |
- Gutsche, C., et al.
(författare)
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Forces between single pairs of charged colloids in aqueous salt solutions
- 2007
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Ingår i: Physical Review E (Statistical, Nonlinear, and Soft Matter Physics). - 1539-3755. ; 76:3
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Tidskriftsartikel (refereegranskat)abstract
- Forces between single pairs of negatively charged micrometer-sized colloids in aqueous solutions of monovalent, divalent, or trivalent counter-ions at varying concentrations have been measured by employing optical tweezers. The experimental data have been analyzed by using the Derjaguin-Landau-Verwey-Overbeek (DLVO) theory and a numerical solution of the Poisson-Boltzmann (PB) equation. With monovalent counterions, the data are well described by the DLVO and PB theories, suggesting that the DLVO theory is adequate to describe the colloidal forces at these conditions. At higher counter-ion valence, the approximations within the two theories become evident.
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| 3. |
- Dreier, J. P., et al.
(författare)
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Migraine and delayed ischaemic neurological deficit after subarachnoid haemorrhage in women: a case-control study
- 2007
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Ingår i: European Journal of Neurology. - : Wiley. - 1351-5101. ; 14:12, s. 1363-1368
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Tidskriftsartikel (refereegranskat)abstract
- The aim of the present case-control study was to investigate the role of migraine as a potential risk factor for a delayed ischaemic neurological deficit (DIND) after subarachnoid haemorrhage (SAH). A telephone interview was performed in patients or their relatives to determine the prevalence of migraine. Thirty-six women aged < 60 years had SAH with Hunt & Hess grade I-III and DIND (group A). This group was compared with an age-matched group of 36 female SAH patients, Hunt & Hess grade I-III without DIND (group B). The two populations were also characterized regarding hypertension, smoking, diabetes mellitus and alcohol use. A significant difference was only found for the prevalence of migraine with 47% in group A and 25% in group B (P < 0.05; odds ratio: 2.68, confidence interval: 0.99-7.29). Migraineurs revealed similar prevalences of risk factors independently of the presence of DINDs. This retrospective study suggests that women with migraine have a higher risk to develop a DIND than women without migraine.
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| 4. |
- Finnveden, Svante, et al.
(författare)
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A model of wall pressure correlation for prediction of turbulence-induced vibration
- 2005
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Ingår i: Journal of Fluids and Structures. - : Elsevier BV. - 0889-9746 .- 1095-8622. ; 20:8, s. 1127-1143
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Tidskriftsartikel (refereegranskat)abstract
- The vibration response of a structure excited by a turbulent boundary layer is investigated experimentally and numerically. First, the wall pressure in a high speed acoustic wind tunnel is characterized and the cross-spectral density is approximated using a Corcos model with frequency dependent correlation lengths and a modified Chase model. Both models agree quite well with the measured cross spectrum. Second, based on these turbulence models, the vibration response is predicted and compared to measurements. At lower frequencies both models perform well. In a higher frequency region, however, the vibration response is greatest for length scales that are much longer than the one given by the convection velocity of the turbulence, and in this frequency region only the modified Chase model works effectively.
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| 5. |
- Huyghe, Jeroen R., et al.
(författare)
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Genome-wide SNP-based linkage scan identifies a locus on 8q24 for an age-related hearing impairment trait
- 2008
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Ingår i: American Journal of Human Genetics. - : Cell Press. - 0002-9297 .- 1537-6605. ; 83:3, s. 401-407
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Tidskriftsartikel (refereegranskat)abstract
- Age-related hearing impairment (ARHI), or presbycusis, is a very common multifactorial disorder. Despite the knowledge that genetics play an important role in the etiology of human ARHI as revealed by heritability studies, to date, its precise genetic determinants remain elusive. Here we report the results of a cross-sectional family-based genetic study employing audiometric data. By using principal component analysis, we were able to reduce the dimensionality of this multivariate phenotype while capturing most of the variation and retaining biologically important features of the audiograms. We conducted a genome-wide association as well as a linkage scan with high-density SNP microarrays. Because of the presence of genetic population substructure, association testing was stratified after which evidence was combined by meta-analysis. No association signals reaching genome-wide significance were detected. Linkage analysis identified a linkage peak on 8q24.13-q24.22 for a trait correlated to audiogram shape. The signal reached genome-wide significance, as assessed by simulations. This finding represents the first locus for an ARHI trait.
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| 6. |
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| 7. |
- Schneppenheim, Reinhard, et al.
(författare)
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A common origin of the 4143insA ADAMTS13 mutation
- 2006
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Ingår i: Thrombosis and Haemostasis. - 0340-6245. ; 96:1, s. 3-6
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Tidskriftsartikel (refereegranskat)abstract
- Severely deficient activity of the von Willebrand Factor (VWF) cleaving metalloprotease,ADAMTS 13, is associated with thrombotic thrombocytopenic purpura (TTP). The mutation spectrum ofADAMTS 13 is rather heterogeneous, and numerous mutations spread across the gene have been described in association with congenital TTP. The 4143insA mutation is unusual with respect to its geographic concentration. Following the initial report from Germany in which the 4143insA mutation was detected in four apparently unrelated families, we have now identified this mutation in a further eleven patients from Norway, Sweden, Poland, Germany, the Czech Republic and Australia. Confirmation that the Australian patient is of German ancestry, together with the Northern and Central European origin of most of the other patients, suggests that the 4143insA mutation has a common genetic background.We established ADAMTS 13 haplotypes by analyzing 17 polymorphic intragenic markers.The haplotypes linked to 4143insA were identical in all informative families. Three novel candidate mutations, C347S, P67IL and RI060W, as well as the known mutation R507Q, were also identified during the course of the study.We conclude that 4143insA has a common genetic background and is frequent among patients with hereditary ADAMTS 13 deficiency in Northern and Central European countries.
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| 8. |
- Van Laer, Lut, et al.
(författare)
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The grainyhead like 2 gene (GRHL2), alias TFCP2L3, is associated with age-related hearing impairment
- 2008
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Ingår i: Human Molecular Genetics. - : Oxford University Press. - 0964-6906 .- 1460-2083. ; 17:2, s. 159-169
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Tidskriftsartikel (refereegranskat)abstract
- Age-related hearing impairment (ARHI) is the most prevalent sensory impairment in the elderly. ARHI is a complex disease caused by an interaction between environmental and genetic factors. The contribution of various environmental factors has been relatively extensively studied. In contrast, investigations to identify the genetic risk factors have only recently been initiated. In this paper we describe the results of an association study performed on 2418 ARHI samples derived from nine centers from seven European countries. In 70 candidate genes, a total of 768 tag single nucleotide polymorphisms (SNPs) were selected based on HAPMAP data. These genes were chosen among the monogenic hearing loss genes identified in mice and men in addition to several strong functional candidates. After genotyping and data polishing, statistical analysis of all samples combined resulted in a P-value that survived correction for multiple testing for one SNP in the GRHL2 gene. Other SNPs in this gene were also associated, albeit to a lesser degree. Subsequently, an analysis of the most significant GRHL2 SNP was performed separately for each center. The direction of the association was identical in all nine centers. Two centers showed significant associations and a third center showed a trend towards significance. Subsequent fine mapping of this locus demonstrated that the majority of the associated SNPs reside in intron 1. We hypothesize that the causative variant may change the expression levels of a GRHL2 isoform.
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