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Prevention of CMV/E...
Prevention of CMV/EBV reactivation by double-specific T cells in patients after allogeneic stem cell transplantation : results from the randomized phase I/IIa MULTIVIR-01 study
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- Gerbitz, Armin (författare)
- Univ Hosp Erlangen, Dept Med Hematol Oncol 5, Erlangen, Germany.;Princess Margaret Canc Ctr, Div Med Oncol Hematol, Toronto, ON, Canada.
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- Gary, Regina (författare)
- Univ Hosp Erlangen, Dept Med Hematol Oncol 5, Erlangen, Germany.
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- Aigner, Michael (författare)
- Univ Hosp Erlangen, Dept Med Hematol Oncol 5, Erlangen, Germany.
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- Moosmann, Andreas (författare)
- LMU Univ Hosp, Dept Med 3, Munich, Germany.;Helmholtz Ctr Munich, Inst Virol, Munich, Germany.;German Ctr Infect Res, Deutsch Zentrum Infektionsforsch DZIF, Munich, Germany.
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- Kremer, Anita (författare)
- Univ Hosp Erlangen, Dept Med Hematol Oncol 5, Erlangen, Germany.
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- Schmid, Christoph (författare)
- Univ Hosp Augsburg, Dept Med 2, Augsburg, Germany.
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- Hirschbuehl, Klaus (författare)
- Univ Hosp Augsburg, Dept Med 2, Augsburg, Germany.
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- Wagner, Eva (författare)
- Univ Hosp Mainz, Dept Med 3, Mainz, Germany.
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- Hauptrock, Beate (författare)
- Univ Hosp Mainz, Dept Med 3, Mainz, Germany.
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- Teschner, Daniel (författare)
- Univ Hosp Mainz, Dept Med 3, Mainz, Germany.
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- Roesler, Wolf (författare)
- Univ Hosp Erlangen, Dept Med Hematol Oncol 5, Erlangen, Germany.
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- Spriewald, Bernd (författare)
- Univ Hosp Erlangen, Dept Med Hematol Oncol 5, Erlangen, Germany.
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- Tischer, Johanna (författare)
- LMU Univ Hosp, Dept Med 3, Munich, Germany.
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- Moi, Stephanie (författare)
- Univ Hosp Erlangen, Dept Med Hematol Oncol 5, Erlangen, Germany.
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- Balzer, Heidi (författare)
- Univ Hosp Erlangen, Dept Med Hematol Oncol 5, Erlangen, Germany.
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- Schaffer, Stefanie (författare)
- Univ Hosp Erlangen, Dept Med Hematol Oncol 5, Erlangen, Germany.
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- Bausenwein, Judith (författare)
- Univ Hosp Erlangen, Dept Med Hematol Oncol 5, Erlangen, Germany.
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- Wagner, Anja (författare)
- Univ Hosp Erlangen, Dept Med Hematol Oncol 5, Erlangen, Germany.
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- Schmidt, Franziska (författare)
- Univ Hosp Erlangen, Dept Med Hematol Oncol 5, Erlangen, Germany.
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- Brestrich, Jens (författare)
- Charite, Dept Hematol Oncol & Tumor Immunol, Berlin, Germany.
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- Ullrich, Barbara (författare)
- Univ Hosp Erlangen, Med Ctr Informat & Commun Technol, Erlangen, Germany.
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- Maas, Stefanie (författare)
- Univ Hosp Erlangen, Ctr Clin Studies CCS, Erlangen, Germany.
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- Herold, Susanne (författare)
- Univ Hosp Erlangen, Ctr Clin Studies CCS, Erlangen, Germany.
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- Strobel, Julian (författare)
- Univ Hosp Erlangen, Dept Transfus Med, Erlangen, Germany.
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- Zimmermann, Robert (författare)
- Univ Hosp Erlangen, Dept Transfus Med, Erlangen, Germany.
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- Weisbach, Volker (författare)
- Univ Hosp Erlangen, Dept Transfus Med, Erlangen, Germany.
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- Hansmann, Leo (författare)
- Charite, Dept Hematol Oncol & Tumor Immunol, Berlin, Germany.
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- Lammoglia-Cobo, Fernanda (författare)
- Charite, Dept Hematol Oncol & Tumor Immunol, Berlin, Germany.
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- Remberger, Mats, Professor, 1955- (författare)
- Uppsala universitet,Hematologi,Uppsala Univ Hosp, Clin Res & Dev Unit KFUE, Uppsala, Sweden.
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- Stelljes, Matthias (författare)
- Univ Hosp Muenster, Dept Hematol Oncol, Munster, Germany.
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- Ayuk, Francis (författare)
- Univ Hosp Eppendorf, Dept Stem Cell Transplantat, Hamburg, Germany.
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- Zeiser, Robert (författare)
- Univ Hosp Freiburg, Dept Med 1, Freiburg, Germany.
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- Mackensen, Andreas (författare)
- Univ Hosp Erlangen, Dept Med Hematol Oncol 5, Erlangen, Germany.
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Univ Hosp Erlangen, Dept Med Hematol Oncol 5, Erlangen, Germany;Princess Margaret Canc Ctr, Div Med Oncol Hematol, Toronto, ON, Canada. Univ Hosp Erlangen, Dept Med Hematol Oncol 5, Erlangen, Germany. (creator_code:org_t)
- Frontiers Media S.A. 2023
- 2023
- Engelska.
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Ingår i: Frontiers in Immunology. - : Frontiers Media S.A.. - 1664-3224. ; 14
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- IntroductionAllogeneic stem cell transplantation is used to cure hematologic malignancies or deficiencies of the hematopoietic system. It is associated with severe immunodeficiency of the host early after transplant and therefore early reactivation of latent herpesviruses such as CMV and EBV within the first 100 days are frequent. Small studies and case series indicated that application of herpes virus specific T cells can control and prevent disease in this patient population.MethodsWe report the results of a randomized controlled multi centre phase I/IIa study (MULTIVIR-01) using a newly developed T cell product with specificity for CMV and EBV derived from the allogeneic stem cell grafts used for transplantation. The study aimed at prevention and preemptive treatment of both viruses in patients after allogeneic stem cell transplantation targeting first infusion on day +30. Primary endpoints were acute transfusion reaction and acute-graft versus-host-disease after infusion of activated T cells.ResultsThirty-three patients were screened and 9 patients were treated with a total of 25 doses of the T cell product. We show that central manufacturing can be achieved successfully under study conditions and the product can be applied without major side effects. Overall survival, transplant related mortality, cumulative incidence of graft versus host disease and number of severe adverse events were not different between treatment and control groups. Expansion of CMV/EBV specific T cells was observed in a fraction of patients, but overall there was no difference in virus reactivation.DiscussionOur study results indicate peptide stimulated epitope specific T cells derived from stem cell grafts can be administered safely for prevention and preemptive treatment of reactivation without evidence for induction of acute graft versus host disease.Clinical trial registrationhttps://clinicaltrials.gov, identifier NCT02227641.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- cytomegalovirus CMV
- Epstein-Barr virus EBV
- allogeneic
- stem cell transplantation (SCT)
- epitope specificity
- prevention
- reactivation
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Gerbitz, Armin
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Gary, Regina
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Aigner, Michael
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Moosmann, Andrea ...
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Kremer, Anita
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Schmid, Christop ...
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Hirschbuehl, Kla ...
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Wagner, Eva
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Hauptrock, Beate
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Teschner, Daniel
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Roesler, Wolf
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Spriewald, Bernd
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Tischer, Johanna
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Moi, Stephanie
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Balzer, Heidi
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Schaffer, Stefan ...
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Bausenwein, Judi ...
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Wagner, Anja
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Schmidt, Franzis ...
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Brestrich, Jens
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Ullrich, Barbara
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Maas, Stefanie
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Herold, Susanne
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Strobel, Julian
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Zimmermann, Robe ...
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Weisbach, Volker
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Hansmann, Leo
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Lammoglia-Cobo, ...
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Remberger, Mats, ...
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Stelljes, Matthi ...
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Ayuk, Francis
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Zeiser, Robert
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Mackensen, Andre ...
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