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- Kristenson, Margareta, et al.
(författare)
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The role of saliva cortisol measurements in health and disease : A matter of theory and methodology
- 2010
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Ingår i: International Journal of Behavioral Medicine. - : Springer. - 1070-5503 .- 1532-7558. ; , s. S206-S206
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Konferensbidrag (refereegranskat)abstract
- Over the last decade, the technique of using ambulatory salivary sampling has become increasingly popular in field research and clinical studies. The non-invasive method is easy to administer and analyze and allows implmentation in large scale study designs. However, this large interest in the use of salivary cortisol measurement is paralleled with frustrations on opposing results. This presentation is based on a critical evaluation of the existing literature on salivary cortisol, aiming to evaluate the utility of salivary cortisol as a biomarker in various settings and how we can understand cortisol reactivity using evidence of experiences from different study designs. The work is compiled by the Scandinavian Stress and Cortisol Network, a network financed by the Swedish Research Council, and one main question asked was: is it possible that different results of studies involving cortisol assessments are functions of differences in the theoretical assumptions made and methods used. In particular, the symposium will focus on how the many different ways of evaluating levels and dynamics of salivary cortisol (i. e. with regard to time points of assessment and different algorithms based on multiple time points) may have an impact on the interpretation of cortisol measurements in various contexts. Salivary cortisol has been studied in relation to the following topics: demographic variables, psychosocial work environment, psychosocial resources (e.g. mastery) and outcomes (e.g. burnout), sleep quality, biological markers (markers of cardivascular risk, inflammation and metabolism) and somatic outcome.
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| 2. |
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| 3. |
- Mitchell, Amanda M, et al.
(författare)
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HOPELESSNESS THE "ACTIVE INGREDIENT"? ASSOCIATIONS OF HOPELESSNESS AND DEPRESSIVE SYMPTOMS WITH INTERLEUKIN-6
- 2013
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Ingår i: International Journal of Psychiatry in Medicine. - : Baywood Publishing. - 0091-2174 .- 1541-3527. ; 46:1, s. 109-117
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Previous research has revealed a relationship of depressive symptoms and hopelessness with cardiovascular diseases (CVDs) which are associated with elevated levels of interleukin-6 (IL-6). The objective of this study was to explore whether depressive symptoms and hopelessness are independent predictors of IL-6 levels. Method: Hopelessness, depressive symptoms, and IL-6 were measured in 45 Swedish adults (26 women and 19 men; age range: 31-65 years). Two separated linear regressions were conducted with hopelessness and depressive symptoms serving as individual predictors of IL-6. Another regression analysis examined whether the two predictors predict IL-6 when controlling for each other. The regression coefficients of the models with one predictor and with both predictors were compared. Results: As predicted, after adjusting for age, BMI, illness, smoking, and gender, more depressive symptoms and more hopelessness predicted higher IL-6 levels in independent regressions. When controlling for each other, hopelessness, but not depressive symptoms, predicted IL-6 levels. Finally, when controlling for hopelessness, the regression between depressive symptoms and IL-6 level was significantly reduced; however, there was no significant change in the regression between hopelessness and IL-6 level when controlling for depressive symptoms. Conclusions: Thus, these results suggest that depressive symptoms and hopelessness are not independent predictors of IL-6 levels. Future research should explore the interplay of hopelessness and depressive symptoms on other risk factors of CVDs.
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