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- Saxena, Richa, et al.
(författare)
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Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
- 2010
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:2, s. 142-148
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Tidskriftsartikel (refereegranskat)abstract
- Glucose levels 2 h after an oral glucose challenge are a clinical measure of glucose tolerance used in the diagnosis of type 2 diabetes. We report a meta-analysis of nine genome-wide association studies (n = 15,234 nondiabetic individuals) and a follow-up of 29 independent loci (n = 6,958–30,620). We identify variants at the GIPR locus associated with 2-h glucose level (rs10423928, β (s.e.m.) = 0.09 (0.01) mmol/l per A allele, P = 2.0 × 10−15). The GIPR A-allele carriers also showed decreased insulin secretion (n = 22,492; insulinogenic index, P = 1.0 × 10−17; ratio of insulin to glucose area under the curve, P = 1.3 × 10−16) and diminished incretin effect (n = 804; P = 4.3 × 10−4). We also identified variants at ADCY5 (rs2877716, P = 4.2 × 10−16), VPS13C (rs17271305, P = 4.1 × 10−8), GCKR (rs1260326, P = 7.1 × 10−11) and TCF7L2 (rs7903146, P = 4.2 × 10−10) associated with 2-h glucose. Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies (n = 35,869 cases, 89,798 controls, OR = 1.12, 95% CI 1.09–1.15, P = 4.8 × 10−18).
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| 3. |
- Abdesselam, A., et al.
(författare)
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Boosted objects : a probe of beyond the standard model physics
- 2011
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 71:6, s. 1661-
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Tidskriftsartikel (refereegranskat)abstract
- We present the report of the hadronic working group of the BOOST2010 workshop held at the University of Oxford in June 2010. The first part contains a review of the potential of hadronic decays of highly boosted particles as an aid for discovery at the LHC and a discussion of the status of tools developed to meet the challenge of reconstructing and isolating these topologies. In the second part, we present new results comparing the performance of jet grooming techniques and top tagging algorithms on a common set of benchmark channels. We also study the sensitivity of jet substructure observables to the uncertainties in Monte Carlo predictions.
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| 4. |
- Hauber, Ernst, et al.
(författare)
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DEBRIS FLOW FANS AND PERMAFROST LANDFORMS ON SVALBARD (NORWAY): TERRESTRIAL ANALOGUES FOR MARTIAN MID-LATITUDE PERIGLACIAL LANDSCAPES.
- 2010
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Ingår i: 41st Lunar and Planetary Science Conference. ; :1922
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Konferensbidrag (refereegranskat)abstract
- Many young landforms on Mars that were probably formed by exogenic processes show a latitude- dependent geographic distribution. They include surface mantling, lobate debris aprons, lineated valley fill, and concentric crater fill, viscous flow features, gullies, and patterned ground. Collectively, these landforms are hypothesized to represent the surface records of Martian ice ages that were induced by astronomical forcing and associated climate changes. Previous studies often considered just one of the features in isolation (e.g., gullies), without taking into account the geomorphologic context. A more comprehensive investigation of the full assemblage of landforms (landscape analysis), however, has the potential to reduce the ambiguity in interpreting landforms (the problem of equifinality, e.g., in the case of pingos), and to reveal the evolution of the climatic environment in more detail. Here we present permafrost landforms of Svalbard (Norway) as useful terrestrial analogues for the suite of possible periglacial landforms that are typically found at mid-latitudes on Mars. We build on our previous investigations of gullies and fans, and include a number of classical periglacial landforms (patterned ground, rock glaciers, pingos) that all have close morphological analogues on Mars. Based on this comparison, we propose an evolutionary scenario which helps to understand the sequential formation of the Martian landforms into their present state.
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| 5. |
- Krohn, I. K., et al.
(författare)
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Cultured Mast Cells from Patients with Asthma and Controls Respond with Similar Sensitivity to Recombinant Der P2-Induced, IgE-Mediated Activation
- 2013
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Ingår i: Scandinavian Journal of Immunology. - : Wiley. - 1365-3083 .- 0300-9475. ; 78:4, s. 352-356
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Tidskriftsartikel (refereegranskat)abstract
- The function of cultured mast cells may depend on genetic or environmental influence on the stem cell donor. This study investigates whether asthma or atopy in the donor influenced the growth and sensitivity of mast cells cultured from patients with asthma and healthy controls under identical conditions. Mast cells were cultured from peripheral blood from twelve patients with an objectively confirmed asthma diagnosis and eight healthy subjects. During the last 2weeks of culture, mast cells were incubated with IL-4 and 80kU/l recombinant human IgE containing two clones (7%+7%) specific for mite allergen Der p2. The sensitivity of IgE-mediated activation of mast cells was investigated as Fc epsilon RI-mediated upregulation of CD63. Ten subjects were atopic, defined as a positive skin prick test (>3mm) to at least one of ten common allergens. After activation with recombinant Der p2, the maximum CD63 median fluorescence intensity was 20 456 +/- 1640 (SE) for patients with asthma and 22 275 +/- 1971 (SE) for controls (ns). The fraction of CD63 positive cells was 54.4% in patients with asthma and 48.4% in controls (ns). The allergen concentration inducing 50% of the maximal CD63 response was similar in patients with asthma [-0.4795 log ng/ml +/- 0.092 (SE)] and controls (-0.6351 log ng/ml +/- 0.083, ns) and in atopic and non-atopic subjects. When cultured, sensitized and activated under identical conditions, mast cells from allergic asthmatics and healthy controls respond similar. Activation of cultured mast cells appears to depend on culture conditions (IL-4, IgE) rather than on donor status as atopy and asthma.
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