| 1. |
- Ottosson-Laakso, Emilia, et al.
(författare)
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Glucose-induced Changes in Gene Expression in Human Pancreatic Islets - Causes or Consequences of Chronic Hyperglycemia
- 2017
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Ingår i: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 66:12, s. 3013-3028
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Tidskriftsartikel (refereegranskat)abstract
- Dysregulation of gene expression in islets from type 2 diabetic patients might be causally involved in the development of hyperglycemia or it could develop as a consequence of hyperglycemia, i.e. glucotoxicity. To separate the genes potentially causally involved in pathogenesis from those likely to be secondary to the hyperglycemia we exposed islets from human donors to normal or high glucose concentrations for 24 hours and analyzed gene expression. We compared these findings with gene expression in islets from donors with normal glucose tolerance (NGT) and hyperglycemia (HG, including T2D). The genes whose expression changed in the same direction after short-term glucose exposure as in T2D were considered most likely to be a consequence of hyperglycemia. Genes whose expression changed in HG but not after short-term glucose exposure, in particular genes that also correlated with insulin secretion, were considered the strongest candidates for causal involvement in T2D. E.g. ERO1LB, DOCK10, IGSF11 and PRR14L were down-regulated in HG and correlated positively with insulin secretion suggesting a protective role while TMEM132C was up-regulated in HG and correlated negatively with insulin secretion suggesting a potential pathogenic role.This study provides a catalogue of gene expression changes in human pancreatic islets after exposure to glucose.
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| 2. |
- Andersson, Håkan, et al.
(författare)
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A co-simulation method for system-level simulation of fluid-structure couplings in hydraulic percussion units
- 2017
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Ingår i: Engineering with Computers. - : SPRINGER. - 0177-0667 .- 1435-5663. ; 33:2, s. 317-333
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Tidskriftsartikel (refereegranskat)abstract
- This paper addresses a co-simulation method for fluid power driven machinery equipment, i.e. oil hydraulic machinery. In these types of machinery, the fluid-structure interaction affects the end-product performance to a large extent, hence an efficient co-simulation method is of high importance. The proposed method is based on a 1D system model representing the fluid components of the hydraulic machinery, within which structural 3D Finite Element (FE) models can be incorporated for detailed simulation of specific sub-models or complete structural assemblies. This means that the fluid system simulation will get a more accurate structural response, and that the structural simulation will get more correct fluid loads at every time step, compared to decoupled analysis. Global system parameters such as fluid flow, performance and efficiency can be evaluated from the 1D system model simulation results. From the 3D FE-models, it is possible to evaluate displacements, stresses and strains to be used in stress analysis, fatigue evaluation, acoustic analysis, etc. The method has been implemented using two well-known simulation tools for fluid power system simulations and FE-simulations, respectively, where the interface between the tools is realised by use of the Functional Mock-up Interface standard. A simple but relevant model is used to validate the method.
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| 3. |
- Axin, Mikael, 1984-, et al.
(författare)
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A Flexible Working Hydraulic System for Mobile Machines
- 2016
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Ingår i: International Journal of Fluid Power. - : Taylor & Francis. - 1439-9776 .- 2332-1180. ; 17:2, s. 79-89
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- This paper proposes a novel working hydraulic system architecture for mobile machines. Load sensing, flow control and open-centre are merged into a generalized system description. The proposed system is configurable and the operator can realize the characteristics of any of the standard systems without compromising energy efficiency. This can be done non-discretely on-the-fly. One electrically controlled variable displacement pump supplies the system and conventional closed-centre spool valves are used. The pump control strategies are explained in detail. Experimental results demonstrate one solution to the flow matching problem and the static and dynamic differences between different control modes.
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| 4. |
- Axin, Mikael
(författare)
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Mobile Working Hydraulic System Dynamics
- 2015
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis deals with innovative working hydraulic systems for mobile machines. Flow control systems are studied as an alternative to load sensing. The fundamental difference is that the pump is controlled based on the operator’s command signals rather than feedback signals from the loads. This control approach enables higher energy efficiency and there is no load pressure feedback causing stability issues. Experimental results show a reduced pump pressure margin and energy saving potential for a wheel loader application.The damping contribution from the inlet and outlet orifice in directional valves is studied. Design rules are developed and verified by experiments.A novel system architecture is proposed where flow control, load sensing and open-centre are merged into a generalized system description. The proposed system is configurable and the operator can realize the characteristics of any of the standard systems without compromising energy efficiency. This can be done non-discretely on-the-fly. Experiments show that it is possible to avoid unnecessary energy losses while improving system response and increasing stability margins compared to load sensing. Static and dynamic differences between different control modes are also demonstrated experimentally.
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| 5. |
- Baer, Katharina, 1984-, et al.
(författare)
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Aspects of Parameter Sensitivity for Series Hydraulic Hybrid Light-Weight Duty Vehicle Design
- 2016
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Ingår i: Proceedings of the 9th FPNI Ph.D. Symposium on Fluid Power (FPNI2016). - : American Society of Mechanical Engineers. - 9780791850473
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Konferensbidrag (refereegranskat)abstract
- Hybridization of a vehicle’s drivetrain can in principle help to improve its energy efficiency by allowing for recuperation of kinetic energy and modulating the engine’s load. How well this can be realized depends on appropriate sizing and control of the additional components. The system is typically designed sequentially, with the hardware setup preceding the development and tuning of advanced controller architectures. Taking an alternative approach, component sizing and controller tuning can be addressed simultaneously through simulation-based optimization.The results of such optimizations, especially with standard algorithms with continuous design variable ranges, can however be difficult to realize, considering for example limitations in available components. Furthermore, drive-cycle based optimizations are prone to cycle-beating. This paper examines the results of such simulation-based optimization for a series hydraulic hybrid vehicle in terms of sensitivity to variations in design parameters, system parameters and drive cycle variations. Additional relevant aspects concerning the definition of the optimization problem are pointed out.
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| 6. |
- Baer, Katharina, et al.
(författare)
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Design Study and Parameter Optimization for a Light-Weight Series Hydraulic Hybrid Vehicle
- 2015
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Konferensbidrag (refereegranskat)abstract
- Hydraulic hybrid drives are one potential way of improving the fuel efficiency of vehicles, including the possi-bility of recuperating braking energy in a hydraulic accumulator. The high power density of fluid power is mainly advantageous for heavy vehicles, or duty cycles characterized with frequent braking and acceleration. For smaller vehicles, hydraulic hybrid drives are thus most interesting under urban and suburban driving conditions. Amongst the existing architectures, the series hydraulic hybrid offers the advantage of operating the internal combustion engine independently of the vehicle speed, at the cost of a less efficient transmission path than a purely mechanical one. Previously, a series hydraulics hybrid light-duty vehicle was modelled in the transmission-line modelling (TLM)-based simulation software Hopsan from the division of Fluid and Mechatronic Systems (Flumes) at Linköping University. This paper studies through simulation-based optimi-zation how the fuel-optimal vehicle design is affected by various mixes of urban and suburban driving requirements. Both the system’s hardware and the parameters of a basic control strategy are considered. The results show quite similar designs for most performance requirements combinations, and can be the base for further studies addressing additional requirements, conditions and objectives.
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| 7. |
- Baer, Katharina, 1984-, et al.
(författare)
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Framework for simulation-based simultaneous system optimization for a series hydraulic hybrid vehicle
- 2019
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Ingår i: International Journal of Fluid Power. - : Taylor & Francis. - 1439-9776 .- 2332-1180. ; 20:1, s. 27-51
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Tidskriftsartikel (refereegranskat)abstract
- Hybridisation of hydraulic drivetrains offers the potential of efficiency improvement for on – and off-road applications. To realise the advantages, a carefully designed system and corresponding control strategy are required, which are commonly obtained through a sequential design process. Addressing component selection and control parameterisation simultaneously through simulation-based optimisation allows for exploration of a large design space as well as design relations and trade-offs, and their evaluation in dynamic conditions which exist in real driving scenarios. In this paper, the optimisation framework for a hydraulic hybrid vehicle is introduced, including the simulation model for a series hybrid architecture and component scaling considerations impacting the system’s performance. A number of optimisation experiments for an on-road light-duty vehicle, focused on standard-drive-cycle-performance, illustrate the impact of the problem formulation on the final design and thus the complexity of the design problem. The designs found demonstrate both the potential of energy storage in series hybrids, via an energy balance diagram, as well as some challenges. The framework presented here provides a base for systematic evaluation of design alternatives and problem formulation aspects.
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| 8. |
- Baer, Katharina, 1984-
(författare)
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Simulation-Based Optimization of a Series Hydraulic Hybrid Vehicle
- 2018
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Hybrid transmissions are characterized by their utilization of more than one form of energy storage. They have the potential to help reduce overall fuel consumption and vehicle emissions by providing the possibility of brake energy recuperation and prime mover operation management. Electric hybrids and electric vehicle drives are nowadays ubiquitous, and mechanical energy storage in flywheel has been investigated in the past. The use of fluid power technology with a combustion engine has also been investigated since the late 1970s, and is frequently revisited.Hydraulic hybridization is especially attractive for heavy vehicles with frequent braking and acceleration which benefit most from fluid power components’ high power density, typically busses, delivery or refuse vehicles, and vehicles with existing hydraulic circuits and transmissions, such as forest and construction machinery, but have been considered for smaller vehicles as well.Due to the characteristic discharge profile of hydraulic energy storage, special attention needs to be paid to control aspects in the design process to guarantee drivability of the vehicle. In this respect, simulation models can be of use in early design process stages for cheaper and faster evaluation of concepts and designs than physical experiments and prototyping, and to generate better understanding of the system studied. Engineering optimization aids in the systematic exploration of a given design space, to determine limits and potentials, evaluate trade-offs and potentially find unexpected solutions. In the optimization of a hydraulic hybrid transmission, the integration of component and controller design is of importance, and different strategies (sequential, iterative, bi-level and simultaneous approaches) are conceivable, with varying consequences for the implementation.This thesis establishes a simulation-based optimization framework for a hydraulic hybrid transmission with series architecture. Component and control parameter optimization are addressed simultaneously, using a rule-based supervisory control strategy. The forward-facing dynamic simulation model at the centre of the framework is built in Hopsan, a multi-disciplinary open-source tool developed at Linköping University. The optimization is set up and conducted for an example application of an on-road light-duty truck over standard drive cycles. Both results from these experiments as well as the framework itself are studied and evaluated. Relevant design aspects, such as explicit design relations to be considered and performance requirements for more robust design, are identified and addressed, and the optimization problem is analysed with regard to algorithm performance and problem formulation. The final result is an optimization framework that can be adjusted for further in-depth studies, for example through the inclusion of additional components or optimization objectives, and extendable for comparative analysis of different topologies, applications and problem formulations.
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| 9. |
- Bennet, Hedvig, et al.
(författare)
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Altered serotonin (5-HT) 1D and 2A receptor expression may contribute to defective insulin and glucagon secretion in human type 2 diabetes.
- 2015
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Ingår i: Peptides. - : Elsevier BV. - 1873-5169 .- 0196-9781. ; 71, s. 113-120
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Tidskriftsartikel (refereegranskat)abstract
- Islet produced 5-hydroxy tryptamine (5-HT) is suggested to regulate islet hormone secretion in a paracrine and autocrine manner in rodents. Hitherto, no studies demonstrate a role for this amine in human islet function, nor is it known if 5-HT signaling is involved in the development of beta cell dysfunction in type 2 diabetes (T2D). To clarify this, we performed a complete transcriptional mapping of 5-HT receptors and processing enzymes in human islets and investigated differential expression of these genes in non-diabetic and T2D human islet donors. We show the expression of fourteen 5-HT receptors as well as processing enzymes involved in the biosynthesis of 5-HT at the mRNA level in human islets. Two 5-HT receptors (HTR1D and HTR2A) were over-expressed in T2D islet donors. Both receptors (5-HT1d and 5-HT2a) were localized to human alpha, beta and delta cells. 5-HT inhibited both insulin and glucagon secretion in non-diabetic islet donors. In islets isolated from T2D donors the amine significantly increased release of insulin in response to glucose. Our results suggest that 5-HT signaling participates in regulation of overall islet hormone secretion in non- diabetic individuals and over-expression of HTR1D and HTR2A may either contribute to islet dysfunction in T2D or arise as a consequence of an already dysfunctional islet.
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| 10. |
- Braun, Robert
(författare)
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Distributed System Simulation Methods : For Model-Based Product Development
- 2015
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Distributed system simulation can increase performance, re-usability and modularity in model-based product development. This thesis investigates four aspects of distributed simulation: multi-threaded simulations, simulation tool coupling, distributed equation solvers and parallel optimization algorithms.Multi-threaded simulation makes it possible to split up the workload over several processing units. This reduces simulation time, which can save both time and money during the product development cycle. The transmission line element method (TLM) is used to decouple models to independent sub-models.Different simulation tools are suitable for different problems. Tool coupling makes it possible to use the best suited tool for simulating each part of the whole product. Models from different tools can then be coupled into one aggregated simulation model. An emerging standard for tool coupling is the Functional Mock-up Interface (FMI). It is investigated how this can be used in conjunction with TLM.Equation-based object-oriented languages (EOOs) are becoming increasing popular. A logical approach is to let the equation solvers maintain the same structure that was used in the modelling process. Methods for achieving this using TLM and FMI are implemented and evaluated.In addition to parallel simulations, it is also possible to use parallel optimization algorithms. This introduces parallelism on several levels. For this reason, an algorithm for profile-based multi-level scheduling is proposed.
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