Sökning: WFRF:(Kudlak Blazej)
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The effect of sunsc...
The effect of sunscreen 4-methylbenzylidene camphor in different and reproductive models, its bioaccumulation and molecular effects on ligand-receptor interaction, and protein expression
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- Lax, Cassandra (författare)
- Uppsala universitet,Funktionell farmakologi och neurovetenskap
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- Wicksell, Elin (författare)
- Uppsala universitet,Funktionell farmakologi och neurovetenskap
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- Grip, Anastasia (författare)
- Uppsala universitet,Funktionell farmakologi och neurovetenskap
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- Niemi, Jenni Viivi Linnea (författare)
- Uppsala universitet,Funktionell farmakologi och neurovetenskap
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- Liu, Wen (författare)
- Uppsala universitet,Funktionell farmakologi och neurovetenskap
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- Rafeletou, Alexandra (författare)
- Uppsala universitet,Funktionell farmakologi och neurovetenskap
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- Kudlak, Blazej (författare)
- Gdansk Univ Technol, Fac Chem, Dept Analyt Chem, Gdansk, Poland.
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- Schiöth, Helgi B. (författare)
- Uppsala universitet,Funktionell farmakologi och neurovetenskap
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(creator_code:org_t)
- Wiley-Blackwell, 2023
- 2023
- Engelska.
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Ingår i: Basic & Clinical Pharmacology & Toxicology. - : Wiley-Blackwell. - 1742-7835 .- 1742-7843. ; 133:2, s. 130-141
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- 4-Methylbenzylidene camphor (4-MBC) is a photo-absorbing UV filter prevalently used in cosmetics, which can be absorbed into circulation and cause systemic effects. 4-MBC is continued to be released in the environment despite the growing knowledge about its bioaccumulation and endocrine disrupting effects. Previous reviews have mentioned UV-filter together but this review considers 4-MBC alone, due to its prevalence and concerning health effects. This review considers 4-MBC's potential effects on human health regarding systemic and molecular effects, with the main focus on reproduction. Also, the potential bioaccumulation and interactions with receptor systems such as the oestrogen receptors beta and alpha, and progesterone receptor are covered. Additionally, previous studies about 4-MBC's effects on mRNA and protein expression, especially in the prostate and the brain are analysed. Furthermore, 4-MBC is reported to act with inflammatory pathways by activating p38 MAPK and NF-kappa B, leading to the production of inflammatory TNF-alpha and IL-6. 4-MBC was also found to induce apoptosis and inhibit cell proliferation and DNA repair. In conclusion, 4-MBC has wide-ranging effects in many different models interacting with multiple pathways causing long-term effects even at low doses and this knowledge can guide governmental risk assessment, regulation divisions and chemical industries.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- 4-MBC
- bioaccumulation
- endocrine disruption
- reproduction
- sunscreen
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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