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Restricted spiromet...
Restricted spirometry and cardiometabolic comorbidities: results from the international population based BOLD study
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- Kulbacka-Ortiz, Katarzyna (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Triest, F. J. J. (författare)
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Franssen, F. M. E. (författare)
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Wouters, E. F. M. (författare)
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Studnicka, M. (författare)
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Vollmer, W. M. (författare)
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Lamprecht, B. (författare)
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Burney, P. G. J. (författare)
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Amaral, A. F. S. (författare)
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- Vanfleteren, Lowie E G W (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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(creator_code:org_t)
- 2022-02-17
- 2022
- Engelska.
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Ingår i: Respiratory research. - : Springer Science and Business Media LLC. - 1465-993X. ; 23:1
- Relaterad länk:
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https://respiratory-...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background Whether restricted spirometry, i.e. low Forced Vital Capacity (FVC), predicts chronic cardiometabolic disease is not definitely known. In this international population-based study, we assessed the relationship between restricted spirometry and cardiometabolic comorbidities. Methods A total of 23,623 subjects (47.5% males, 19.0% current smokers, age: 55.1 +/- 10.8 years) from five continents (33 sites in 29 countries) participating in the Burden of Obstructive Lung Disease (BOLD) study were included. Restricted spirometry was defined as post-bronchodilator FVC < 5th percentile of reference values. Self-reports of physician-diagnosed cardiovascular disease (CVD; heart disease or stroke), hypertension, and diabetes were obtained through questionnaires. Results Overall 31.7% of participants had restricted spirometry. However, prevalence of restricted spirometry varied approximately ten-fold, and was lowest (8.5%) in Vancouver (Canada) and highest in Sri Lanka (81.3%). Crude odds ratios for the association with restricted spirometry were 1.60 (95% CI 1.37-1.86) for CVD, 1.53 (95% CI 1.40-1.66) for hypertension, and 1.98 (95% CI 1.71-2.29) for diabetes. After adjustment for age, sex, education, Body Mass Index (BMI) and smoking, the odds ratios were 1.54 (95% CI 1.33-1.79) for CVD, 1.50 (95% CI 1.39-1.63) for hypertension, and 1.86 (95% CI 1.59-2.17) for diabetes. Conclusion In this population-based, international, multi-site study, restricted spirometry associates with cardiometabolic diseases. The magnitude of these associations appears unattenuated when cardiometabolic risk factors are taken into account.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Restricted spirometry
- Lung function impairment
- Cardiovascular disease
- Hypertension
- Diabetes
- Comorbidity
- coronary-heart-disease
- lung-function
- cardiovascular-disease
- association
- prevalence
- risk
- copd
- adulthood
- capacity
- smoking
- Respiratory System
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Kulbacka-Ortiz, ...
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Triest, F. J. J.
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Franssen, F. M. ...
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Wouters, E. F. M ...
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Studnicka, M.
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Vollmer, W. M.
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visa fler...
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Lamprecht, B.
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Burney, P. G. J.
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Amaral, A. F. S.
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Vanfleteren, Low ...
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visa färre...
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Göteborgs universitet