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Nutraceuticals and mitochondrial oxidative stress : bridging the gap in the management of bronchial asthma

Allam, Venkata Sita Rama Raju (författare)
Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
Paudel, Keshav Raj (författare)
Centenary Inst, Ctr Inflammat, Sydney, NSW 2007, Australia.;Univ Technol Sydney, Fac Sci, Sch Life Sci, Sydney, NSW 2007, Australia.
Gupta, Gaurav (författare)
Suresh Gyan Vihar Univ, Sch Pharm, Jaipur, Rajasthan, India.;Saveetha Univ, Saveetha Dent Coll, Saveetha Inst Med & Tech Sci, Dept Pharmacol, Chennai, Tamil Nadu, India.;Uttaranchal Univ, Uttaranchal Inst Pharmaceut Sci, Dehra Dun, Uttarakhand, India.
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Singh, Sachin Kumar (författare)
Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara, Punjab, India.;Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, POB 123 Broadway, Ultimo, NSW 2007, Australia.
Vishwas, Sukriti (författare)
Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara, Punjab, India.
Gulati, Monica (författare)
Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara, Punjab, India.;Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, POB 123 Broadway, Ultimo, NSW 2007, Australia.
Gupta, Saurabh (författare)
Chitkara Univ, Chitkara Coll Pharm, Rajpura, Punjab, India.
Chaitanya, M. V. N. L. (författare)
Chitkara Univ, Chitkara Coll Pharm, Rajpura, Punjab, India.
Jha, Niraj Kumar (författare)
Sharda Univ, Sch Engn & Technol SET, Dept Biotechnol, Greater Noida, Uttar Pradesh, India.;Uttaranchal Univ, Sch Appl & Life Sci SALS, Dept Biotechnol, Dehra Dun 248007, Uttarakhand, India.
Gupta, Piyush Kumar (författare)
Sharda Univ, Sch Basic Sci & Res SBSR, Dept Life Sci, Greater Noida, Uttar Pradesh, Australia.
Patel, Vyoma K. (författare)
Univ New South Wales, Fac Med & Hlth, Sch Clin Med, Sydney, NSW 2052, Australia.;Univ Technol Sydney, Fac Hlth, Australian Res Ctr Complementary & Integrat Med, Ultimo, NSW 2007, Australia.
Liu, Gang (författare)
Centenary Inst, Ctr Inflammat, Sydney, NSW 2007, Australia.;Univ Technol Sydney, Fac Sci, Sch Life Sci, Sydney, NSW 2007, Australia.
Kamal, Mohammad Amjad (författare)
King Abdulaziz Univ, King Fahd Med Res Ctr, POB 80216, Jeddah 21589, Saudi Arabia.;Sichuan Univ, West China Hosp, Frontiers Sci Ctr Dis Related Mol Network, Inst Syst Genet, Chengdu, Peoples R China.;Novel Global Community Educ Fdn, Enzymo, 7 Peterlee Pl, Hebersham, NSW 2770, Australia.;Daffodil Int Univ, Fac Allied Hlth Sci, Dept Pharm, Dhaka 1207, Bangladesh.
Hansbro, Philip M. (författare)
Centenary Inst, Ctr Inflammat, Sydney, NSW 2007, Australia.;Univ Technol Sydney, Fac Sci, Sch Life Sci, Sydney, NSW 2007, Australia.
Oliver, Brian Gregory George (författare)
Univ Technol Sydney, Fac Sci, Sch Life Sci, Ultimo, NSW, Australia.;Univ Sydney, Woolcock Inst Med Res, Sydney, NSW, Australia.
Chellappan, Dinesh Kumar (författare)
Int Med Univ, Sch Pharm, Dept Life Sci, Kuala Lumpur 57000, Malaysia.
Dua, Kamal (författare)
Univ Sydney, Woolcock Inst Med Res, Sydney, NSW, Australia.;Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, POB 123 Broadway, Ultimo, NSW 2007, Australia.;Univ Technol Sydney, Fac Hlth, Australian Res Ctr Complementary & Integrat Med, Ultimo, NSW 2007, Australia.
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 (creator_code:org_t)
2022-07-07
2022
Engelska.
Ingår i: Environmental Science and Pollution Research. - : Springer Nature. - 0944-1344 .- 1614-7499. ; 29:42, s. 62733-62754
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Forskningsöversikt (refereegranskat)
Abstract Ämnesord
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  • Asthma is a chronic inflammatory disease primarily characterized by inflammation and reversible bronchoconstriction. It is currently one of the leading causes of morbidity and mortality in the world. Oxidative stress further complicates the pathology of the disease. The current treatment strategies for asthma mainly involve the use of anti-inflammatory agents and bronchodilators. However, long-term usage of such medications is associated with severe adverse effects and complications. Hence, there is an urgent need to develop newer, novel, and safe treatment modalities for the management of asthma. This has therefore prompted further investigations and detailed research to identify and develop novel therapeutic interventions from potent untapped resources. This review focuses on the significance of oxidative stressors that are primarily derived from both mitochondrial and non-mitochondrial sources in initiating the clinical features of asthma. The review also discusses the biological scavenging system of the body and factors that may lead to its malfunction which could result in altered states. Furthermore, the review provides a detailed insight into the therapeutic role of nutraceuticals as an effective strategy to attenuate the deleterious effects of oxidative stress and may be used in the mitigation of the cardinal features of bronchial asthma.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)

Nyckelord

Nutraceuticals
Mitochondria
Oxidative stress
Asthma
Inflammation
Therapeutics

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