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- Birney, Ewan, et al.
(författare)
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Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
- 2007
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 447:7146, s. 799-816
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Tidskriftsartikel (refereegranskat)abstract
- We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These data have been further integrated and augmented by a number of evolutionary and computational analyses. Together, our results advance the collective knowledge about human genome function in several major areas. First, our studies provide convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts, including non-protein-coding transcripts, and those that extensively overlap one another. Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their relationship to specific regulatory sequences and features of chromatin accessibility and histone modification. Third, a more sophisticated view of chromatin structure has emerged, including its inter-relationship with DNA replication and transcriptional regulation. Finally, integration of these new sources of information, in particular with respect to mammalian evolution based on inter- and intra-species sequence comparisons, has yielded new mechanistic and evolutionary insights concerning the functional landscape of the human genome. Together, these studies are defining a path for pursuit of a more comprehensive characterization of human genome function.
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- Myslivets, E., et al.
(författare)
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1.56-μs continuously tunable parametric delay line for a 40-Gb/s signal
- 2009
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Ingår i: Optics Express. - 1094-4087 .- 1094-4087. ; 17:14, s. 11958-11964
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Tidskriftsartikel (refereegranskat)abstract
- Experimental demonstration of an all-fiber, all-optical continuously tunable delay line is reported. The 1.56-mu s delay with a record 62,400 time-delay bit-rate product was characterized for a 40-Gbps data channel. The result was enabled by parametric dispersion compensation with cascaded triple-conversion in highly-nonlinear fiber capable of continuous tuning over 39.5 nm.
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| 10. |
- Zhang, Hongqiang, et al.
(författare)
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A structure model for τ(μ) phase in Al-Cr-Si alloys deduced from λ phase by the strong reflections approach
- 2006
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Ingår i: Acta Crystallographica Section B. - 0108-7681 .- 1600-5740. ; 62:1, s. 16-25
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Tidskriftsartikel (refereegranskat)abstract
- There are very obvious common features in the electron diffraction patterns of the λ and τ(μ) phases in the Al–Cr–Si system. The positions of the strong reflections and their intensity distributions are similar for the two structures. The relation of the reciprocal lattices of the λ and τ(μ) phases is studied. By applying the strong-reflections approach, the structure factors of τ(μ) are deduced from the corresponding structure factors of the known λ phase. Rules for selecting reflections for the strong-reflections approach are described. Similar to that of λ, the structure of τ(μ) contains six layers stacked along the c axis in each unit cell. There are 752 atoms in each unit cell, 53 of them are unique. The corresponding composition of the τ(μ) model is Al3.82 − xCrSix. Simulated electron diffraction patterns from the structure model are in good agreement with the experimental ones. The arrangement of interpenetrated icosahedral clusters in the τ(μ) phase is discussed.
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