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| 2. |
- Mainini, A. G., et al.
(författare)
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Demonstration in Relevant Environments
- 2022
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Ingår i: SpringerBriefs in Applied Sciences and Technology. - Cham : Springer Science and Business Media Deutschland GmbH. ; , s. 95-119
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Bokkapitel (refereegranskat)abstract
- Three building case studies were chosen with the purpose of demonstrating the BIM4EEB BIM-based toolkit. The selected buildings are both social houses and residential apartments respecting the needs of vulnerable inhabitants. To increase the representativeness of the test case the buildings are located in three different locations with different climatic conditions, specifically Italy, Poland, Finland. For all the case studies analysed, BIM models were created with different levels of detail (LOD), which, thanks to the interaction with the BIMMS, make it possible to create a common environment for the representation and use of the data collected and subsequently shared between the different tools. Among the three demonstration sites, the Italian site is undergoing building envelope renovation interventions such as the realization of the thermal insulation with ETICS technologies and the replacement of external windows. In order to test the different tools, a demonstration procedure has been defined for them, constituted mainly by workshop activities and quantitative and qualitative evaluations. To assess the level of accomplishment with respect to stated objectives and project success a validation methodology based on Key Performance Indicators (KPIs) was delineated. Precisely, two categories of KPIs have been identified: “mandatory” and “secondary” addressing project objectives and in connection with the literature review and project use cases and tools. To calculate the KPIs standard baselines were estimated, such as are currently in an ongoing process to assess the traditional process that can be compared with the actual value associated with the BIM-based process. The chapter will present the methods and the first intermediate results of a demonstration process that is currently not yet completed and will later see a further application of the tools in dedicated demo sites. Environmental monitoring sensors were installed in selected apartments in Polish and Italian demo site, while were installed in common spaces for the Finnish building. Specific sensors set up have been analysed and chosen to fulfil the different needs related to the specific project outcomes. Inhabitants’ availability, technical condition and flat exposition were criteria followed for the choice of apartments. Sensors allowed to improve the occupancy monitoring and to have a historical record of environmental values such as temperature, humidity and light strictly connected to users’ preferences. The mobile application about renovation activities performed and residents’ indoor home conditions—BIM4Occupants—has been installed by the users and specific workshops with inhabitants were carried out for registration purposes. The BIM Management System is currently collecting sensors’ data stream and data stream between tools such as BIM4Occupants and BIMPlanner. Project monitoring and better communication among users were tested in a different workshop by applying the BIMPlanner tool in the plans and progress site operations. The functionalities of the refurbishment scenario simulation tool—BIMeaser—were tested in qualitative and quantitative design workshops respectively with the construction professionals using the two pilot sites in Italy and in Finland and with the aim of assessing the achieved time savings of using this tool compared to the manual data input process of the scenario simulation. © 2022, The Author(s).
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| 3. |
- Bolognesi, C. M., et al.
(författare)
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Digital Tools for Fast Mapping of Buildings
- 2022
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Ingår i: SpringerBriefs in Applied Sciences and Technology. - Cham : Springer Science and Business Media Deutschland GmbH. ; , s. 51-62
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- While the construction sector embraces digitalization, new technologies related to it are spreading benefits. The need of creating a 3D model of a building, a digital copy of something existing, is not new. Mediated by the advent of photographic and laser instrumentation, the construction of a digital model has crossed the fields of surveying with increasing accuracy and precision, imposing standards of capturing the existing first and modelling then ever higher. But while the Building Information Modelling allows a virtual representation of the existing asset enriching its geometry with precious and significant information related to its properties, advanced survey has always faced the impossibility to break the surface of the building, surveying what is inside walls, thus excluding what necessary should be contained within a BIM model. Also, BIM models do not consider the real-time component and do not report the real-time behaviour of the building. In this chapter we will investigate several technologies and instruments exploited till now for the surveying and positioning of existing buildings, plants included, and a new toolkit based on AR that, coupled with sensors and visualisation tools developed by BIM4EEB, offers many advantages when surveying the whole building. © 2022, The Author(s).
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| 4. |
- Kurkinen, Kimmo, et al.
(författare)
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Sammanfattning av tidigare mätningar av fukt- och temperaturförhållanden för trä i klimatskärmen
- 2009
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The report is a summary of earlier measurements of moisture and temperature measurement in the building envelope. The content is based on an overview of research reports, scientific papers and conference papers in the field of building physics. The main purpose is to get an understanding for the moisture- and temperature conditions for wood in the building envelope. Another purpose is to identify the need of additional measurements in laboratory and in field. The report is a deliverable in project WPB Exposure of wood in the building envelope. This project is part of WoodBuild, a research programme within the Sectoral R&D Programme 2006-2012 for the Swedish forest-based industry. This Programme is jointly funded by the government, industry and other stakeholders with interests related to the Swedish forest-based industry.
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| 5. |
- Martiskainen, Henna, et al.
(författare)
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Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models
- 2015
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Ingår i: Neurobiology of Aging. - : Elsevier BV. - 0197-4580 .- 1558-1497. ; 36:2, s. 1221e15-1221e28
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Tidskriftsartikel (refereegranskat)abstract
- In this study, we have assessed the expression and splicing status of genes involved in the pathogenesis or affecting the risk of Alzheimer's disease (AD) in the postmortem inferior temporal cortex samples obtained from 60 subjects with varying degree of AD-related neurofibrillary pathology. These subjects were grouped based on neurofibrillary pathology into 3 groups: Braak stages 0-II, Braak stages III-IV, and Braak stages V-VI. We also examined the right frontal cortical biopsies obtained during life from 22 patients with idiopathic shunt-responding normal pressure hydrocephalus, a disease that displays similar pathologic alterations as seen in AD. These 22 patients were categorized according to dichotomized amyloid-β positive or negative pathology in the biopsies. We observed that the expression of FRMD4A significantly decreased, and the expression of MS4A6A significantly increased in relation to increasing AD-related neurofibrillary pathology. Moreover, the expression of 2 exons in both CLU and TREM2 significantly increased with increase in AD-related neurofibrillary pathology. However, a similar trend toward increased expression in CLU and TREM2 was observed with most of the studied exons, suggesting a global change in the expression rather than altered splicing. Correlation of gene expression with well-established AD-related factors, such as α-, β-, and γ-secretase activities, brain amyloid-β42 levels, and cerebrospinal fluid biomarkers, revealed a positive correlation between β-secretase activity and the expression of TREM2 and BIN1. In expression quantitative trait loci analysis, we did not detect significant effects of the risk alleles on gene expression or splicing. Analysis of the normal pressure hydrocephalus biopsies revealed no differences in the expression or splicing profiles of the studied genes between amyloid-β positive and negative patients. Using the protein-protein interaction-based in vitro pathway analysis tools, we found that downregulation of FRMD4A associated with increased APP-β-secretase interaction, increased amyloid-β40 secretion, and altered phosphorylation of tau. Taken together, our results suggest that the expression of FRMD4A, MS4A6A, CLU, and TREM2 is altered in relation to increasing AD-related neurofibrillary pathology, and that FRMD4A may play a role in amyloidogenic and tau-related pathways in AD. Therefore, investigation of gene expression changes in the brain and effects of the identified genes on disease-associated pathways in vitro may provide mechanistic insights on how alterations in these genes may contribute to AD pathogenesis.
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| 6. |
- Natunen, Teemu, et al.
(författare)
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Elucidation of the BACE1 Regulating Factor GGA3 in Alzheimer's Disease
- 2013
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Ingår i: Journal of Alzheimer's Disease. - 1387-2877 .- 1875-8908. ; 37:1, s. 217-232
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Tidskriftsartikel (refereegranskat)abstract
- Golgi-localized gamma-ear-containing ADP-ribosylation factor-binding protein (GGA3) is a central regulator of trafficking and degradation of BACE1 (beta-site A beta PP-cleaving enzyme), the rate-limiting enzyme in the production of amyloid-beta (A beta) in Alzheimer's disease (AD). Here, we assessed the potential role of GGA3 in AD pathogenesis using independent neuropathological, case-control, and family-based human sample cohorts. Increased BACE1 levels coincided with decreased GGA3 levels and with elevated phosphorylation status of eIF2 alpha-Ser51 in the temporal cortex of AD patients as compared to age-matched controls. Severity of the disease did not alter mRNA or protein levels of GGA3 in the inferior temporal cortex of AD patients, while a positive correlation between GGA3 and the levels of total, but not phosphorylated, tau was observed. Genetically, we did not observe consistent evidence for association between AD risk and common GGA3 polymorphisms across a number of independent sample cohorts. However, a nominally significant association was observed with rs2242230 (p < 0.05) among the Finnish case-control cohort. Accordingly, mRNA and protein levels of GGA3 in the inferior temporal cortex of AD patients did not significantly correlate with rs2242230 genotype status. While the present study indicates that GGA3 is involved in the cellular processes relevant for AD pathogenesis, the genetic data do not support the idea that common GGA3 polymorphisms would contribute to AD risk.
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