| 1. |
- Nordenfelt, E, et al.
(författare)
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No in vivo effect of trisodium phosphonoformate on woodchuck hepatitis virus production
- 1982
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Ingår i: Acta pathologica, microbiologica, et immunologica Scandinavica. Section B, Microbiology. - 0108-0180. ; 90:6, s. 449-451
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Tidskriftsartikel (refereegranskat)abstract
- The efficient in vitro inhibition of hepatitis B virus DNA polymerase by trisodium phosphonoformate (PFA, INN: foscarnet sodium) and its low toxicity suggested that PFA could be used as a therapeutic agent for hepatitis B infection. PFA was also found to inhibit woodchuck hepatitis virus (WHV) DNA polymerase in vitro. As a model to test PFA's eventual effect, chronically WHV infected woodchucks were treated with PFA. The animals were treated twice daily in a dosage which gave a minimum serum level of PFA corresponding to an in vitro inhibiting effect on WHV DNA polymerase of about 40%. The concentration in liver tissue was found to be 15% below serum level. The amount of WHV particles in serum was followed by DNA polymerase assay. No effect on WHV production could be seen during 2 weeks' treatment. No change of the in vitro sensitivity to PFA of the WHV DNA polymerase was seen. These results indicate that the WHV associated DNA polymerase has no role in the production of viral particles.
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| 2. |
- Valentin, Lil, et al.
(författare)
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Subjective recording of fetal movements. I. Limits and acceptability in normal pregnancies
- 1984
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Ingår i: Acta Obstetricia et Gynecologica Scandinavica. - 1600-0412. ; 63:3, s. 223-228
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Tidskriftsartikel (refereegranskat)abstract
- Maternal counting of fetal movements is increasingly used as a clinical method for assessment of fetal health. The present study established normal limits for two methods of subjective fetal movement recording. Four hundred-and-seventeen randomly selected women with low-risk pregnancies recorded the time necessary for 10 fetal movements every morning and also the number of fetal movements during 15 min every evening. The study was carried out between gestational week 34 and parturition. Two hundred-and-twenty-two consecutive women answered a questionnaire after the end of the study. 70% of the women counted fetal movements every day; 66.5% preferred the evening to the morning recording. In a strictly selected normal group (n = 129), no significant change was found in the number of fetal movements or in the time for 10 fetal movements with advancing gestation or approaching parturition. The results of the evening sessions were not influenced by maternal parity, fetal weight, or fetal sex. The great interindividual variation in the results does not allow the application of general normal limits. A method for establishing individual normal low limits for each pregnancy was designed.
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