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| 2. |
- Berry, Max, 1969, et al.
(författare)
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Porcine transfer study: virtual reality simulator training compared with porcine training in endovascular novices
- 2007
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Ingår i: Cardiovasc Intervent Radiol. - : Springer Science and Business Media LLC. - 0174-1551. ; 30:3, s. 455-61
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: To compare the learning of endovascular interventional skills by training on pig models versus virtual reality simulators. METHODS: Twelve endovascular novices participated in a study consisting of a pig laboratory (P-Lab) and a virtual reality laboratory (VR-Lab). Subjects were stratified by experience and randomized into four training groups. Following 1 hr of didactic instruction, all attempted an iliac artery stenosis (IAS) revascularization in both laboratories. Onsite proctors evaluated performances using task-specific checklists and global rating scales, yielding a Total Score. Participants completed two training sessions of 3 hr each, using their group's assigned method (P-Lab x 2, P-Lab + VR-Lab, VR-Lab + P-Lab, or VR-Lab x 2) and were re-evaluated in both laboratories. A panel of two highly experienced interventional radiologists performed assessments from video recordings. ANCOVA analysis of Total Score against years of surgical, interventional radiology (IR) experience and cumulative number of P-Lab or VR-Lab sessions was conducted. Inter-rater reliability (IRR) was determined by comparing proctored scores with the video assessors in only the VR-Lab. RESULTS: VR-Lab sessions improved the VR-Lab Total Score (beta = 3.029, p = 0.0015) and P-Lab Total Score (beta = 1.814, p = 0.0452). P-Lab sessions increased the P-Lab Total Score (beta = 4.074, p < 0.0001) but had no effect on the VR-Lab Total Score. In the general statistical model, both P-Lab sessions (beta = 2.552, p = 0.0010) and VR-Lab sessions (beta = 2.435, p = 0.0032) significantly improved Total Score. Neither previous surgical experience nor IR experience predicted Total Score. VR-Lab scores were consistently higher than the P-Lab scores (Delta = 6.659, p < 0.0001). VR-Lab IRR was substantial (r = 0.649, p < 0.0008). CONCLUSIONS: Endovascular skills learned in the virtual environment may be transferable to the real catheterization laboratory as modeled in the P-Lab.
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| 3. |
- Cuenot, P., et al.
(författare)
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Engineering support for automotive embedded systems beyond autosar
- 2009
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Ingår i: AutoTechnology. - 1616-8216. ; 9:2, s. 46-50
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Tidskriftsartikel (refereegranskat)abstract
- The future de-facto standard for automotive Electric/Electronic (E/E) software architectures of the AUTomotive Open System ARchitecture (Autosar) initiative is gaining momentum in the automotive industry. This is manifested by the fact that vehicle manufacturers and Tier-1 suppliers are committed to this standard. The initiative's main focus is on software (SW) components at implementation level. EAST-ADL2 is an architecture description language, which is based on Autosar concepts and extends the initiative towards a system engineering approach for automotive embedded software.
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| 4. |
- Delle, M., et al.
(författare)
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Preserved pelvic circulation after stent-graft treatment of complex aortoiliac artery aneurysms: a new approach
- 2005
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Ingår i: Journal of endovascular therapy. - 1526-6028. ; 12:2, s. 189-95
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: To describe an endovascular technique that allows stent-graft treatment of aortoiliac aneurysmal disease affecting both common iliac arteries (CIA), with maintenance of pelvic circulation on one side. TECHNIQUE: For patients with aortoiliac aneurysms, both common femoral arteries (CFA) were surgically exposed. One internal iliac artery (IIA) was initially embolized with coils. A bifurcated stent-graft main body was deployed with the proximal end just below the renal arteries. On the ipsilateral side, the stent-graft limb was extended 3 cm beyond the orifice of the embolized IIA into the external iliac artery (EIA) using stent-graft limb extenders. On the contralateral side, the stent-graft limb was deployed so that the distal end was 10 to 15 mm proximal to the patent IIA orifice. Via a left brachial artery access, the IIA was catheterized, and stent-grafts were deployed from the distal end of the contralateral AAA stent-graft limb into the IIA. A femorofemoral crossover graft provided circulation to the leg ipsilateral to the IIA stent-graft, and the EIA on the same side was ligated. The technique can also be modified to treat isolated bilateral CIA aneurysms. CONCLUSIONS: By extending the distal aspect of the stent-graft into an IIA, bilateral CIA aneurysms can be excluded while preserving pelvic circulation on one side.
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| 5. |
- Lindnér, Per, 1956, et al.
(författare)
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Extended right-sided liver resection for colorectal liver metastases--impact of percutaneous portal venous embolisation
- 2006
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Ingår i: European journal of surgical oncology. - 0748-7983. ; 32:3, s. 292-6
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Tidskriftsartikel (refereegranskat)abstract
- AIM: To compare the outcome after extended right liver lobe resection (ERL) for patients with liver metastases from colorectal cancer with preceding portal vein embolisation (PVE) with a non-PVE-group. METHODS: Nineteen patients underwent ERL (resection of segment 4-8) for colorectal liver metastases after PVE. They were compared with 21 patients that underwent an ERL without embolisation. A comparison was made with 84 patients undergoing right lobe liver resection during the same time period. Survival, post-operative morbidity and mortality were recorded and the volume of the future remnant liver (FRL) was measured with CT. RESULTS: There were major complications in 1/19 patients in the PVE-group and in 6/21 in the non-PVE-group (p=0.04). No post-operative deaths were observed in the PVE-group, compared to three deaths in the non-PVE-group (p=0.09). The median survival in the PVE-group was 32 months, which did not differ from the non-PVE-group. In 21% of the patients that underwent PVE, progression occurred during the time between embolisation and surgery. There was no difference in survival for patients that underwent PVE followed by ERL, compared to patients that underwent standard right lobe liver resection. CONCLUSION: The survival of patients after ERL is comparable with patients that undergo standard right lobe resection and have less liver tumour.
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| 6. |
- Mannerås, Louise, 1980, et al.
(författare)
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Low-frequency electro-acupuncture and physical exercise improve metabolic disturbances and modulate gene expression in adipose tissue in rats with dihydrotestosterone-induced polycystic ovary syndrome.
- 2008
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Ingår i: Endocrinology. - : The Endocrine Society. - 0013-7227 .- 1945-7170. ; 149:7, s. 3559-68
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Tidskriftsartikel (refereegranskat)abstract
- Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder associated with ovulatory dysfunction, hyperandrogenism, abdominal obesity, and insulin resistance. Pharmacotherapy is often unsatisfactory. This study evaluates the effects of low-frequency electro-acupuncture (EA) and physical exercise on metabolic disturbances and adipose tissue mRNA expression of selected genes in a rat PCOS model characterized by insulin resistance and adiposity. Dihydrotestosterone (inducing PCOS) or vehicle (control) was administrated continuously, beginning before puberty. At age 10 wk, PCOS rats were randomly divided into three groups; PCOS, PCOS EA, and PCOS exercise. PCOS EA rats received 2-Hz EA (evoking muscle twitches) three times/wk during 4-5 wk. PCOS exercise rats had free access to a running wheel for 4-5 wk. EA and exercise improved insulin sensitivity, measured by clamp, in PCOS rats. Exercise also reduced adiposity, visceral adipocyte size, and plasma leptin. EA increased plasma IGF-I. Real-time RT-PCR revealed increased expression of leptin and IL-6 and decreased expression of uncoupling protein 2 in visceral adipose tissue of PCOS rats compared with controls. EA restored the expression of leptin and uncoupling protein 2, whereas exercise normalized adipose tissue leptin and IL-6 expression in PCOS rats. Thus, EA and exercise ameliorate insulin resistance in rats with PCOS. This effect may involve regulation of adipose tissue metabolism and production because EA and exercise each partly restore divergent adipose tissue gene expression associated with insulin resistance, obesity, and inflammation. In contrast to exercise, EA improves insulin sensitivity and modulates adipose tissue gene expression without influencing adipose tissue mass and cellularity.
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| 7. |
- Shi, Jianlin, et al.
(författare)
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Combined usage of UML and Simulink in the Design of Embedded Systems : Investigating Scenarios and Structural and Behavioural Mapping
- 2007
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Ingår i: On the 4th workshop of ObjectorientedModeling of Embedded Real-time Systems, Paderborn, Germany, Oct. 2007.
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Konferensbidrag (refereegranskat)abstract
- The multidisciplinary nature of advanced embed-ded systems requires a combined usage of several tools and modeling languages in systems develop-ment. We investigate the needs and some of the pos-sibilities in simultaneous usage of Matlab/Simulink and UML. Structural and behavioral mappings are explored considering the needs for models at differ-ent abstraction level as well as environment models. The representation and mapping between behavioral models, including discrete-time, event-triggered, and continuous time systems is of special concern and solutions are discussed
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