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- Maksimchuk, Pavel O. O., et al.
(författare)
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·OH-Free Catalytic Decomposition of H2O2 by GdVO4:Eu3+ Nanoparticles
- 2023
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Ingår i: The Journal of Physical Chemistry C. - 1932-7447 .- 1932-7455. ; 127:31, s. 15206-15214
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Tidskriftsartikel (refereegranskat)abstract
- H2O2 is known to be one of the initiators provoking biomolecules (lipids and proteins) oxidation and cell mutation and death. In this context, molecules, which can react with H2O2 without generating free radicals such as hydroxyl radicals (·OH), are of special interest as effective preventive antioxidants. In the present study, we report on GdVO4:Eu3+ nanoparticles (NPs) as prospective preventive nanozymes. Synthesized GdVO4:Eu3+ NPs were characterized by TEM, HR-TEM, XRD, SAXS, and XPS methods. It has been revealed that in water solutions GdVO4:Eu3+ NPs are in the form of individual crystalline spheroids with ? = 12.1 ± 1.23 nm and d = 5.76 ± 0.68 nm. Using the optical spectroscopy technique, the possibility for Fenton- and CAT-like reactions in water solutions containing GdVO4:Eu3+ NPs has been analyzed. The protective effect of GdVO4:Eu3+ NPs from H2O2-induced oxidative stress has been estimated using rat hepatocytes and analyzing changes in cells’ mitochondrial potential. It was concluded that the main mechanism of H2O2 decomposition both in aqueous solutions and biological milieu is rather associated with CAT-like reactions that ensure the V4+/V5+ and V3+/V4+ redox cycling.
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- Song, J., et al.
(författare)
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The extracellular matrix of lymph node reticular fibers modulates follicle border interactions and germinal center formation
- 2023
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Ingår i: iScience. - 2589-0042. ; 26:5
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Tidskriftsartikel (refereegranskat)abstract
- Germinal center (GC) formation and antibody production in lymph node follicles require coordinated interactions between B-cells, T-cells and dendritic cells (DCs), orchestrated by the extracellular matrix-rich reticular fiber (RF) network. We describe a unique laminin 523-containing RF network around and between follicles that associates with PDGFrecb(high) CCL19(low)gp38(low) fibroblastic reticular cells (FRC). In the absence of FRC expression of laminin alpha 5 (pdgfrb-cre:Lama5(fl/fl)), pre-Tfh-cells, B-cells and DCs are displaced from follicle borders, correlating with fewer Tfh-cells and GC B-cells. Total DCs are not altered in pdgfrb-cre: Lama5(fl/fl) mice, but cDC2s, which localize to laminin alpha 5 in RFs at follicle borders, are reduced. In addition, PDGFrecb(high)CCL19(low)gp38(low) FRCs show lower Ch25h expression, required for 7 alpha,25-dihydroxycholesterol synthesis that attracts pre-Tfh-cells, B-cells and DCs to follicle borders. We propose that RF basement membrane components represent a type of tissue memory that guides the localization and differentiation of both specialized FRC and DC populations, required for normal lymph node function.
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